Aimée C. Colbath
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View article: Effects of Exercise Speed and Circle Diameter on Markers of Bone and Joint Health in Juvenile Sheep as an Equine Model
Effects of Exercise Speed and Circle Diameter on Markers of Bone and Joint Health in Juvenile Sheep as an Equine Model Open
Though circular exercise is commonly used in equestrian disciplines, it may be at the detriment of horses’ musculoskeletal system. To investigate the effects of circular exercise on bone and joint health, 42 lambs were randomly assigned to…
View article: Clodronate disodium does not produce measurable effects on bone metabolism in an exercising, juvenile, large animal model
Clodronate disodium does not produce measurable effects on bone metabolism in an exercising, juvenile, large animal model Open
Bisphosphonates are commonly used to treat and prevent bone loss, but their effects in active, juvenile populations are unknown. This study examined the effects of intramuscular clodronate disodium (CLO) on bone turnover, serum bone biomar…
View article: Stem cells and platelet-rich plasma for the treatment of naturally occurring equine tendon and ligament injuries: a systematic review and meta-analysis
Stem cells and platelet-rich plasma for the treatment of naturally occurring equine tendon and ligament injuries: a systematic review and meta-analysis Open
BACKGROUND Platelet-rich plasma (PRP) and mesenchymal stromal or stem cells (MSCs) have been investigated as treatments for equine tendon and ligament injuries, but little consensus exists on the efficacy of these treatments. The study sou…
View article: Review of cellular therapies provides new insights into the potential treatment of diverse neurologic diseases in horses and dogs
Review of cellular therapies provides new insights into the potential treatment of diverse neurologic diseases in horses and dogs Open
Neurological diseases and injuries in veterinary patients (horses, dogs, and cats) are complex, and effective treatment options are limited. Neuronal loss, damage to nerve conduction pathways, and inflammation and scarring associated with …
View article: Literature review details and supports the application of platelet-rich plasma products in canine medicine, particularly as an orthobiologic agent for osteoarthritis
Literature review details and supports the application of platelet-rich plasma products in canine medicine, particularly as an orthobiologic agent for osteoarthritis Open
Platelet-rich plasma (PRP) and other platelet-derived products represent a subset of regenerative medicine and have been researched in the veterinary community for the treatment of osteoarthritis, soft tissue wounds, tendinopathies, period…
View article: Effects of Clodronate Disodium on Endocrine Regulation of Bone Growth and Development in Exercising Yearling Horses
Effects of Clodronate Disodium on Endocrine Regulation of Bone Growth and Development in Exercising Yearling Horses Open
View article: Lumbar vertebral bone density is decreased in horses with pituitary pars intermedia dysfunction
Lumbar vertebral bone density is decreased in horses with pituitary pars intermedia dysfunction Open
Background Pathological fractures have been reported in equids with pituitary pars intermedia dysfunction (PPID) but their prevalence and pathogenesis is unknown. Objectives To compare: (1) bone mineral density (BMD) in weight bearing and …
View article: Exercising sheep as a preclinical model for musculoskeletal research
Exercising sheep as a preclinical model for musculoskeletal research Open
OBJECTIVE To establish an orthopedic, preclinical, ovine model of controlled exercise using an equine walker. ANIMALS 20 Dorset-Polypay sheep. PROCEDURES Sheep underwent 11 weeks of exercise, 4 days per week. Exercise duration and intensit…
View article: PSIII-8 Extra-Label Bisphosphonate Effects on Intra-Articular Inflammation in Juvenile Horses Challenged with Intra-Articular Lipopolysaccharide
PSIII-8 Extra-Label Bisphosphonate Effects on Intra-Articular Inflammation in Juvenile Horses Challenged with Intra-Articular Lipopolysaccharide Open
Anecdotal assertions that bisphosphonates, such as clodronate disodium (CD), exhibit anti-inflammatory properties has led to extra-label use, despite a lack of scientific evidence of its efficacy. The objective of this study was to determi…
View article: PSVI-8 Bisphosphonate Pharmacokinetics in Juvenile Horses
PSVI-8 Bisphosphonate Pharmacokinetics in Juvenile Horses Open
Bisphosphonates alter bone metabolism via inhibition of osteoclastic bone resorption. Although bisphosphonates are beneficial to treat bone disease, extra-label use in healthy juvenile horses may interfere with normal bone metabolism. The …
View article: Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses
Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses Open
Background Treatment with phenylbutazone (nonselective COX inhibitor) decreases the diuretic and natriuretic effects of furosemide by nearly 30% but the effects of COX‐2 specific inhibitors (firocoxib) and atypical NSAIDs (dipyrone) are un…
View article: Intra‐articular triamcinolone acetonide injection results in increases in systemic insulin and glucose concentrations in horses without insulin dysregulation
Intra‐articular triamcinolone acetonide injection results in increases in systemic insulin and glucose concentrations in horses without insulin dysregulation Open
Background Corticosteroids are a commonly used, inexpensive intra‐articular treatment for osteoarthritis which may increase the risk for laminitis in horses due, in part, to hyperinsulinaemia. Humans with metabolic syndrome experience incr…
View article: Closing the gap: sex-related differences in osteoarthritis and the ongoing need for translational studies
Closing the gap: sex-related differences in osteoarthritis and the ongoing need for translational studies Open
Clinical insights into sex-related differences in osteoarthritisInitially, it was believed that molecular and cellular mechanism found in a species were ubiquitous amongst its members, regardless of age, sex or other inter-individual facto…
View article: Pharmacokinetics and plasma protein binding of a single dose of clodronate disodium are similar for juvenile sheep and horses
Pharmacokinetics and plasma protein binding of a single dose of clodronate disodium are similar for juvenile sheep and horses Open
OBJECTIVE To determine the single-dose pharmacokinetics of clodronate disodium (CLO) in juvenile sheep and the plasma protein binding (PPB) of CLO in juvenile sheep and horses. ANIMALS 11 juvenile crossbred sheep (252 ± 6 days) for the pha…
View article: Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc
Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc Open
Intervertebral disc degeneration is a common cause of low back pain, the leading cause of disability worldwide. Appropriate preclinical models for intervertebral disc research are essential to achieving a better understanding of underlying…
View article: PSXV-14 Clodronate Use Does not Influence Physical Growth Parameters in Yearling Horses Undergoing Forced Exercise
PSXV-14 Clodronate Use Does not Influence Physical Growth Parameters in Yearling Horses Undergoing Forced Exercise Open
Off-label bisphosphonate use in juvenile horses is widespread despite little scientific understanding of biological and welfare impacts on skeletally immature, exercising horses. Therefore, the objective was to determine the effects of clo…
View article: WITHDRAWN: The Multifaceted Role of Mast Cells in Joint Inflammation and Arthritis
WITHDRAWN: The Multifaceted Role of Mast Cells in Joint Inflammation and Arthritis Open
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our…
View article: Is the Use of Bisphosphonates Putting Horses at Risk? An Osteoclast Perspective
Is the Use of Bisphosphonates Putting Horses at Risk? An Osteoclast Perspective Open
Osteoclasts are unique and vital bone cells involved in bone turnover. These cells are active throughout the individual’s life and play an intricate role in growth and remodeling. However, extra-label bisphosphonate use may impair osteocla…
View article: Current use of biologic therapies for musculoskeletal disease: A survey of board‐certified equine specialists
Current use of biologic therapies for musculoskeletal disease: A survey of board‐certified equine specialists Open
Objective To evaluate the use of mesenchymal stem cells (MSCs), autologous conditioned serum (ACS), platelet‐rich plasma (PRP), and autologous protein solution (APS) for the treatment of equine musculoskeletal disease by diplomates of the …
View article: Average stride length and stride rate of Thoroughbreds and Quarter Horses during racing
Average stride length and stride rate of Thoroughbreds and Quarter Horses during racing Open
The main factors influencing speed in athletes are stride length (SL) and stride rate (SR). However, conflict remains whether SL or SR is the key determinant of higher speeds. Quarter Horses (QH) generally reach higher speeds in their race…
View article: Multimodal characterization of Yucatan minipig behavior and physiology through maturation
Multimodal characterization of Yucatan minipig behavior and physiology through maturation Open
View article: Average stride length and stride rate of Thoroughbreds and Quarter Horses during ‘Sprint’ and ‘Classic’ races
Average stride length and stride rate of Thoroughbreds and Quarter Horses during ‘Sprint’ and ‘Classic’ races Open
The main factors influencing speed in athletes are stride length (SL) and stride rate (SR). However, conflict remains whether SL or SR is the key determinant of higher speeds. Quarter Horses (QH) generally reach higher speeds in their race…
View article: Multimodal characterization of Yucatan minipig behavior and physiology through maturation
Multimodal characterization of Yucatan minipig behavior and physiology through maturation Open
Brain injuries that are induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological me…
View article: Non-specific protection from respiratory tract infections in cattle generated by intranasal administration of an innate immune stimulant
Non-specific protection from respiratory tract infections in cattle generated by intranasal administration of an innate immune stimulant Open
Alternatives to antibiotics for prevention of respiratory tract infections in cattle are urgently needed given the increasing public and regulatory pressure to reduce overall antibiotic usage. Activation of local innate immune defenses in …
View article: Single and repeated intra‐articular injections in the tarsocrural joint with allogeneic and autologous equine bone marrow‐derived mesenchymal stem cells are safe, but did not reduce acute inflammation in an experimental interleukin‐1β model of synovitis
Single and repeated intra‐articular injections in the tarsocrural joint with allogeneic and autologous equine bone marrow‐derived mesenchymal stem cells are safe, but did not reduce acute inflammation in an experimental interleukin‐1β model of synovitis Open
Background Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical and practical advanta…
View article: Induction of Synovitis Using Interleukin-1 Beta: Are There Differences in the Response of Middle Carpal Joint Compared to the Tibiotarsal Joint?
Induction of Synovitis Using Interleukin-1 Beta: Are There Differences in the Response of Middle Carpal Joint Compared to the Tibiotarsal Joint? Open
Background: The effects of recombinant interleukin-1β (rIL-1β) have been described for the middle carpal joint (MCJ). However, we are unaware of any studies that have described the cytological response of the tibiotarsal joint (TTJ)…
View article: Effect of culture duration on chondrogenic preconditioning of equine bone marrow mesenchymal stem cells in self‐assembling peptide hydrogel
Effect of culture duration on chondrogenic preconditioning of equine bone marrow mesenchymal stem cells in self‐assembling peptide hydrogel Open
Ex vivo induction of chondrogenesis is a promising approach to improve upon the use of bone marrow mesenchymal stem cells (MSCs) for cartilage tissue engineering. This study evaluated the potential to induce chondrogenesis with days of cul…