Aimee Withers
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View article: Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays
Automated Label‐Free Assay for Viral Detection and Inhibitor Screening via Biomembrane‐Functionalized Microelectrode Arrays Open
Most virus infection assays have indirect readout such as virus number following entry (e.g., PCR, cell lysis). While effective, these technologies are labor‐intensive, require specialized environments (e.g., sterile or RNA‐free), and dete…
View article: Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons (Adv. Sci. 27/2024)
Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons (Adv. Sci. 27/2024) Open
Neuronal‐Membrane‐on‐Chip The cover highlights a novel platform of interfacing cell membranes derived from primary neurons with organic microelectrode arrays for monitoring ion channel activities at natively‐expressed levels. In article nu…
View article: Modelling Human Gut‐Microbiome Interactions in a 3D Bioelectronic Platform
Modelling Human Gut‐Microbiome Interactions in a 3D Bioelectronic Platform Open
The role of the gut microbiome in various aspects of health and disease is now a well‐established concept in modern biomedicine. Numerous studies have revealed links between host health and microbial activity, spanning from digestion and m…
View article: Simple dynamic cell culture system reduces recording noise in microelectrode array recordings
Simple dynamic cell culture system reduces recording noise in microelectrode array recordings Open
View article: Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons
Microelectrode Arrays Measure Blocking of Voltage‐Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons Open
Drug studies targeting neuronal ion channels are crucial to understand neuronal function and develop therapies for neurological diseases. The traditional method to study neuronal ion‐channel activities heavily relies on the whole‐cell patc…
View article: 3D organic bioelectronics for electrical monitoring of human adult stem cells
3D organic bioelectronics for electrical monitoring of human adult stem cells Open
Conducting polymer scaffolds enable electrical monitoring of the growth of three-dimensional human adult stem cell cultures and facilitate their differentiation into neuron-like cells.
View article: A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity
A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity Open
The blood-brain barrier (BBB) restricts paracellular and transcellular diffusion of compounds and is part of a dynamic multicellular structure known as the “neurovascular unit” (NVU), which strictly regulates the brain homeostasis and micr…
View article: Organic electronic transmembrane device for hosting and monitoring 3D cell cultures
Organic electronic transmembrane device for hosting and monitoring 3D cell cultures Open
3D cell models have made strides in the past decades in response to failures of 2D cultures to translate targets during the drug discovery process. Here, we report on a novel multiwell plate bioelectronic platform, namely, the e-transmembr…
View article: Conducting Polymer‐ECM Scaffolds for Human Neuronal Cell Differentiation
Conducting Polymer‐ECM Scaffolds for Human Neuronal Cell Differentiation Open
3D cell culture formats more closely resemble tissue architecture complexity than 2D systems, which are lacking most of the cell–cell and cell–microenvironment interactions of the in vivo milieu. Scaffold‐based systems integrating natural …
View article: Investigation of Host–Microbe–Parasite Interactions in an In Vitro 3D Model of the Vertebrate Gut
Investigation of Host–Microbe–Parasite Interactions in an In Vitro 3D Model of the Vertebrate Gut Open
In vitro models of the gut–microbiome axis are in high demand. Conventionally, intestinal monolayers grown on Transwell setups are used to test the effects of commensals/pathogens on the barrier integrity, both under homeostatic and pathop…
View article: A 3D bioelectrical interface to assess colorectal cancer progression in vitro
A 3D bioelectrical interface to assess colorectal cancer progression in vitro Open
Conducting polymers such as PEDOT have attracted considerable attention in the tissue engineering field to add an active electrical read-out to 3D cell cultures. However, PEDOT is normally copolymerized with PSS− that possibly degrades aci…
View article: 3D Organic Bioelectronics for Monitoring <i>In Vitro</i> Stem Cell Cultures
3D Organic Bioelectronics for Monitoring <i>In Vitro</i> Stem Cell Cultures Open
Three-dimensional in vitro stem cell models has enabled a fundamental understanding of cues that direct stem cell fate and be used to develop novel stem cell treatments. While sophisticated 3D tissues can be generated, technology that can …
View article: 3D Bioelectronic Model of the Human Intestine
3D Bioelectronic Model of the Human Intestine Open
Organ on chip (OoC) technologies have the potential to improve the translation of promising therapies currently failing in clinical trials at great expense and time due to dissimilarities between animal and human biology. Successful OoC mo…
View article: Synthesis and characterisation of biocompatible organic–inorganic core–shell nanocomposite particles based on ureasils
Synthesis and characterisation of biocompatible organic–inorganic core–shell nanocomposite particles based on ureasils Open
A one-pot route to ureasil core–shell nanoparticles that exhibit low polydispersity, high stability and low cytotoxicity is reported.