Ai‐Min Bao
YOU?
Author Swipe
View article: The China Brain Multi-omics Atlas Project (CBMAP)
The China Brain Multi-omics Atlas Project (CBMAP) Open
The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation of…
View article: Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex
Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex Open
The epigenetic mechanisms that connect aging to neurodegeneration remain incompletely understood, particularly in non-European populations. To address this gap, we constructed a comprehensive DNA methylation atlas of the human prefrontal c…
View article: Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner
Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner Open
Clinical studies have suggested that increased plasma oxytocin (OT) levels are a promising biomarker for bipolar disorder (BD), and our earlier post-mortem study found increased OT activity in the hypothalamic paraventricular nucleus (OTPV…
View article: The China Brain Multi-omics Atlas Project (CBMAP)
The China Brain Multi-omics Atlas Project (CBMAP) Open
The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1,000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation o…
View article: Increased oxytocin/vasopressin ratio in bipolar disorder in a cohort of human postmortem adults
Increased oxytocin/vasopressin ratio in bipolar disorder in a cohort of human postmortem adults Open
Bipolar disorder (BD) and major depressive disorder (MDD) share some common characteristics in stress-related brain circuits, but they also exhibit distinct symptoms. Our previous postmortem research on the immunoreactivity (ir) levels of …
View article: Improving vulnerable Calbindin1− neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory
Improving vulnerable Calbindin1− neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory Open
Background Intraneuronal accumulation of hyperphosphorylated tau is a hallmark of Alzheimer’s disease (AD). Given the significant correlation between tau pathology and memory loss in AD patients, identifying vulnerable brain regions, parti…
View article: Magnetic resonance imaging of postmortem human brain specimens: methodological considerations and prospects in psychoradiology
Magnetic resonance imaging of postmortem human brain specimens: methodological considerations and prospects in psychoradiology Open
Ex vivo magnetic resonance imaging (MRI) has revolutionized psychoradiological research by enabling detailed structural and pathological assessments of the brain in conditions ranging from psychiatric disorders to neurodegenerative disease…
View article: Prevalence of mixed neuropathologies in age‐related neurodegenerative diseases: A community‐based autopsy study in China
Prevalence of mixed neuropathologies in age‐related neurodegenerative diseases: A community‐based autopsy study in China Open
INTRODUCTION Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples from Chinese brain banks. METHODS A total of 1142 brains from six Chinese brain bank…
View article: Ex vivo Magnetic Resonance Imaging of the Human Fetal Brain
Ex vivo Magnetic Resonance Imaging of the Human Fetal Brain Open
Background: The fetal brain undergoes a dynamic process of development during gestation, marked by well-orchestrated events such as neuronal proliferation, migration, axonal outgrowth, and dendritic arborization, mainly elucidated through …
View article: Distinct regional vulnerability to Aβ and iron accumulation in <i>post mortem</i> AD brains
Distinct regional vulnerability to Aβ and iron accumulation in <i>post mortem</i> AD brains Open
INTRODUCTION The paramagnetic iron, diamagnetic amyloid beta (Aβ) plaques and their interaction are crucial in Alzheimer's disease (AD) pathogenesis, complicating non‐invasive magnetic resonance imaging for prodromal AD detection. METHODS …
View article: Navigating the Molecular Maze of Alzheimer’s Disease: Developing A Human Hippocampal Atlas to Bridge Discovery and Clinical Practice
Navigating the Molecular Maze of Alzheimer’s Disease: Developing A Human Hippocampal Atlas to Bridge Discovery and Clinical Practice Open
Alzheimer’s disease (AD), the primary cause of dementia worldwide, persists as an enigma, with the specific molecular and cellular mechanisms driving cognitive decline still eluding understanding. To aid in unraveling this enigma, we gener…
View article: Sexually dimorphic age‐related molecular differences in the entorhinal cortex of cognitively intact elderly: Relation to early Alzheimer's changes
Sexually dimorphic age‐related molecular differences in the entorhinal cortex of cognitively intact elderly: Relation to early Alzheimer's changes Open
Introduction Women are more vulnerable to Alzheimer's disease (AD) than men. The entorhinal cortex (EC) is one of the earliest structures affected in AD. We identified in cognitively intact elderly different molecular changes in the EC in …
View article: Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer’s disease and the potential role of local estrogens
Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer’s disease and the potential role of local estrogens Open
Introduction Epidemiological studies show that women have a higher prevalence of Alzheimer’s disease (AD) than men. Peripheral estrogen reduction during aging in women is proposed to play a key role in this sex-associated prevalence, howev…
View article: Standardized Operational Protocol of Human Brain Banking for Amyotrophic Lateral Sclerosis
Standardized Operational Protocol of Human Brain Banking for Amyotrophic Lateral Sclerosis Open
Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease for which there is currently no reliable treatment. Existing clinical diagnostic methods include neurophysiological examination, neuroimaging, and genetic testi…
View article: Both noise‐floor and tissue compartment difference in diffusivity contribute to FA dependence on <i>b</i>‐value in diffusion MRI
Both noise‐floor and tissue compartment difference in diffusivity contribute to FA dependence on <i>b</i>‐value in diffusion MRI Open
Noninvasive diffusion magnetic resonance imaging (dMRI) has been widely employed in both clinical and research settings to investigate brain tissue microstructure. Despite the evidence that dMRI‐derived fractional anisotropy (FA) correlate…
View article: Sex differences in the neuropathological hallmarks of Alzheimer’s disease: focus on cognitively intact elderly individuals
Sex differences in the neuropathological hallmarks of Alzheimer’s disease: focus on cognitively intact elderly individuals Open
Aims Women are more vulnerable to Alzheimer's disease (AD) than men. We investigated (i) whether and at what age the AD hallmarks, that is, β‐amyloid (Aβ) and hyperphosphorylated Tau (p‐Tau) show sex differences; and (ii) whether such sex …
View article: Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain
Changes of Hypocretin (Orexin) System in Schizophrenia: From Plasma to Brain Open
Hypocretin (also called orexin) regulates various functions, such as sleep-wake rhythms, attention, cognition, and energy balance, which show significant changes in schizophrenia (SCZ). We aimed to identify alterations in the hypocretin sy…
View article: Brain transcriptional regulatory architecture and schizophrenia etiology converge between East Asian and European ancestral populations
Brain transcriptional regulatory architecture and schizophrenia etiology converge between East Asian and European ancestral populations Open
Understanding the genetic architecture of gene expression and splicing in human brain is critical to unlocking the mechanisms of complex neuropsychiatric disorders like schizophrenia (SCZ). Large-scale brain transcriptomic studies are base…