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View article: High-throughput screening identifies FDA approved drug mitiglinide as a novel pyroptosis inhibitor and therapeutic agent for osteoarthritis
High-throughput screening identifies FDA approved drug mitiglinide as a novel pyroptosis inhibitor and therapeutic agent for osteoarthritis Open
View article: Injectable, antioxidant, biomechanically supported nanocomposite hydrogels for the treatment of intervertebral disc degeneration
Injectable, antioxidant, biomechanically supported nanocomposite hydrogels for the treatment of intervertebral disc degeneration Open
View article: Unlocking the power of swine gut bacteria: newly isolated Blautia strain and its metabolites inhibit the replication of Salmonella Typhimurium in macrophages and alleviate DSS-induced colitis in mice
Unlocking the power of swine gut bacteria: newly isolated Blautia strain and its metabolites inhibit the replication of Salmonella Typhimurium in macrophages and alleviate DSS-induced colitis in mice Open
Background Inflammatory bowel disease is a significant health concern for both humans and large-scale farm animals. In the quest for effective alternatives to antibiotics, next-generation probiotics (NGPs) have emerged as a promising optio…
View article: Histidine‐Engineered ZIF‐8 Nanoparticles for High‐Efficiency siRNA Delivery and Gene Therapy of Intervertebral Disc Degeneration
Histidine‐Engineered ZIF‐8 Nanoparticles for High‐Efficiency siRNA Delivery and Gene Therapy of Intervertebral Disc Degeneration Open
Ferroptosis is a major contributor to intervertebral disc degeneration (IVDD) and represents a promising therapeutic target; however, effective medications that specifically target ferroptosis are still lacking. Consequently, strategies ai…
View article: PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis
PSMD14 Stabilizes SLC7A11 to Ameliorate Glucocorticoid‐Induced Osteoporosis by Suppressing Osteocyte Ferroptosis Open
Glucocorticoid‐induced osteoporosis (GIOP) remains the most prevalent complication compromising bone health in patients undergoing glucocorticoid (GC) therapy. Despite its clinical significance, osteocyte death, a pivotal initiator of GC‐d…
View article: Exploring extracellular vesicles as novel therapeutic agents for intervertebral disc degeneration: delivery, applications, and mechanisms
Exploring extracellular vesicles as novel therapeutic agents for intervertebral disc degeneration: delivery, applications, and mechanisms Open
View article: Theaflavins attenuate iron overload-induced liver oxidative injury by inhibiting hepatocyte ferroptosis
Theaflavins attenuate iron overload-induced liver oxidative injury by inhibiting hepatocyte ferroptosis Open
Liver, as a major iron storage organ, is particularly sensitive to oxidative stress-induced damage stemming from iron overload. Thus, antioxidant therapies are often used to reverse oxidative stress-induced tissues damage, however, the cel…
View article: Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial ecological networks via tryptophan metabolism and AHR-Nrf2 signaling
Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial ecological networks via tryptophan metabolism and AHR-Nrf2 signaling Open
In conclusion, this study offers a theoretical framework for understanding the role of the symbiotic bacterium B. thetaiotaomicron in the gut microbiota ecosystem during diarrhea and its interactions with the host's intestinal tract.
View article: Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain
Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain Open
Discogenic pain, caused by intervertebral disc degeneration (IVDD), is a prevalent and challenging condition to treat effectively. Macrophage infiltration with neural ectopic in‐growth resulting from structural disturbances within the inte…
View article: Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis
Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis Open
Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron‐dependent form of cell death, is identified as a criti…
View article: Composition, Influencing Factors, and Effects on Host Nutrient Metabolism of Fungi in Gastrointestinal Tract of Monogastric Animals
Composition, Influencing Factors, and Effects on Host Nutrient Metabolism of Fungi in Gastrointestinal Tract of Monogastric Animals Open
Intestinal fungi, collectively referred to as mycobiota, constitute a small (0.01–2%) but crucial component of the overall intestinal microbiota. While fungi are far less abundant than bacteria in the gut, the volume of an average fungal c…
View article: Effects of Fish Palm Rice and Coconut Palm Rice Oil Mixture on Intestinal Health of Weaned Piglets
Effects of Fish Palm Rice and Coconut Palm Rice Oil Mixture on Intestinal Health of Weaned Piglets Open
Fat not only has a high effective energy value and extra energy effects but is also an ideal energy source. As one of the most commonly used feed oils at present, soybean oil has a high cost despite its good application effect on weaned pi…
View article: Correction: Li et al. The Opening of High-Speed Railway and Coordinated Development of the Core–Periphery Urban Economy in China. Sustainability 2023, 15, 4677
Correction: Li et al. The Opening of High-Speed Railway and Coordinated Development of the Core–Periphery Urban Economy in China. Sustainability 2023, 15, 4677 Open
The authors would like to make the following corrections about the published paper [...]
View article: Fuh@Decm Hydrogel Delays Intervertebral Disc Degeneration Through Macrophage Reprogramming and Antioxidant Properties
Fuh@Decm Hydrogel Delays Intervertebral Disc Degeneration Through Macrophage Reprogramming and Antioxidant Properties Open
View article: Ferroptosis in viral infections: Overview and regulation by nutritional interventions
Ferroptosis in viral infections: Overview and regulation by nutritional interventions Open
Cell death is a defense strategy employed by host cells to combat viral invasion. Viruses can manipulate the host cell death process to facilitate their own dissemination or evade immune surveillance. Ferroptosis, characterized by excessiv…
View article: Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice
Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice Open
Iron overload activates ferroptosis in colonic cells, increases the relative abundance of harmful bacteria, and exacerbates DSS-induced colitis in mice. Iron overload exacerbates DSS-induced ferroptosis and colitis in a microbiota-dependen…
View article: KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression
KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression Open
Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses. However, the specific mechanisms that regulate the senescence …
View article: Spray-dried plasma protects against rotavirus-induced gastroenteritis via regulating macrophage and T cells divergence in weanling pigs
Spray-dried plasma protects against rotavirus-induced gastroenteritis via regulating macrophage and T cells divergence in weanling pigs Open
Infectious gastroenteritis is the major cause for diarrhea in piglets. The protection of spray-dried plasma (SDP) on viral gastroenteritis during the progression of rotavirus (RV) infection remain unclear. In this study, 64 weanling piglet…
View article: Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies
Role of oxidative stress in mitochondrial dysfunction and their implications in intervertebral disc degeneration: Mechanisms and therapeutic strategies Open
View article: Effects of replacing soybean meal with enzymolysis-fermentation compound protein feed on growth performance, apparent digestibility of nutrients, carcass traits, and meat quality in growing-finishing pigs
Effects of replacing soybean meal with enzymolysis-fermentation compound protein feed on growth performance, apparent digestibility of nutrients, carcass traits, and meat quality in growing-finishing pigs Open
View article: Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease
Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease Open
Arteriosclerotic cerebral small vessel disease (aCSVD) is a major cause of stroke and dementia. Although its underlying pathogenesis remains poorly understood, both inflammaging and gut microbiota dysbiosis have been hypothesized to play s…
View article: Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases
Nanocomposite Hydrogels: A Promising Approach for the Treatment of Degenerative Joint Diseases Open
Degenerative joint diseases, as a global public health issue, impose significant burdens on patients’ lives and substantial economic costs on society. Currently, the primary modalities include physical therapy, pharmaceutical intervention,…
View article: Hypoxia‐Preconditioned BMSC‐Derived Exosomes Induce Mitophagy via the BNIP3–ANAX2 Axis to Alleviate Intervertebral Disc Degeneration
Hypoxia‐Preconditioned BMSC‐Derived Exosomes Induce Mitophagy via the BNIP3–ANAX2 Axis to Alleviate Intervertebral Disc Degeneration Open
Intervertebral disc degeneration (IVDD) is a chronic degenerative disease involving the aging and loss of proliferative capacity of nucleus pulposus cells (NPCs), processes heavily dependent on mitochondrial dynamics and autophagic flux. T…
View article: Effects of enzyme supplementation on growth performance, digestibility of phosphorus, femur parameters and fecal microbiota in growing pigs fed different types of diets
Effects of enzyme supplementation on growth performance, digestibility of phosphorus, femur parameters and fecal microbiota in growing pigs fed different types of diets Open
A 42-days study was conducted to evaluate the effects of different dietary types (corn-or wheat-soybean meal-based diet) and phytase (Phy) or a multi-carbohydrase and phytase complex (MCPC) supplementation on growth performance, digestibil…
View article: [Effects of Oxidative Stress on Mitochondrial Functions and Intervertebral Disc Cells].
[Effects of Oxidative Stress on Mitochondrial Functions and Intervertebral Disc Cells]. Open
Intervertebral disc degeneration is widely recognized as one of the main causes of lower back pain. Intervertebral disc cells are the primary cellular components of the discs, responsible for synthesizing and secreting collagen and proteog…
View article: Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration (Small 13/2024)
Enhanced Mitochondrial Targeting and Inhibition of Pyroptosis with Multifunctional Metallopolyphenol Nanoparticles in Intervertebral Disc Degeneration (Small 13/2024) Open
View article: Injectable nanocomposite hydrogels with enhanced lubrication and antioxidant properties for the treatment of osteoarthritis
Injectable nanocomposite hydrogels with enhanced lubrication and antioxidant properties for the treatment of osteoarthritis Open
View article: Global, regional, and national burden of neck pain, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
Global, regional, and national burden of neck pain, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 Open
View article: Autophagic Flux Not Redox State Commands Ferroptosis Susceptibility in Polarized Macrophages
Autophagic Flux Not Redox State Commands Ferroptosis Susceptibility in Polarized Macrophages Open
View article: Mulberry Leaf (<i>Morus Alba</i> L.) Benefits the Intestinal Health Via Direct Anti-Oxidation and Indirect Modulation of Microbiota in Weanling Pigs
Mulberry Leaf (<i>Morus Alba</i> L.) Benefits the Intestinal Health Via Direct Anti-Oxidation and Indirect Modulation of Microbiota in Weanling Pigs Open