Aina Gotoh
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View article: Suppression of fecal phenol production by oral supplementation of sesamol: inhibition of tyrosine phenol-lyase by sesamol
Suppression of fecal phenol production by oral supplementation of sesamol: inhibition of tyrosine phenol-lyase by sesamol Open
Oral sesamol supplementation in mice suppressed fecal phenol production, partly by inhibiting bacterial l -tyrosine phenol-lyase, suggesting its potential to prevent physiological disorders linked to fecal phenol.
View article: Author Response: Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild
Author Response: Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Peer review Author response Article and author information Metrics Abstract Mic…
View article: Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild
Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Reviewer #2 (Public Review): Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Reviewer #2 (Public Review): Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Author Response: Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Author Response: Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Reviewer #3 (Public Review): Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Reviewer #3 (Public Review): Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Reviewer #1 (Public Review): Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Reviewer #1 (Public Review): Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Reviewer #1 (Public Review): Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Reviewer #1 (Public Review): Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Reviewer #2 (Public Review): Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Reviewer #2 (Public Review): Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild
Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Author Response: Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild
Author Response: Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of Drosophila in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of <i>Drosophila</i> in the Wild
Identification of Key Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth of <i>Drosophila</i> in the Wild Open
Microbiota consisting of various fungi and bacteria have a significant impact on the physiological functions of the host. However, it is unclear which species are essential to this impact and how they affect the host. This study analyzed a…
View article: Comprehensive analysis of metabolites produced by co-cultivation of Bifidobacterium breve MCC1274 with human iPS-derived intestinal epithelial cells
Comprehensive analysis of metabolites produced by co-cultivation of Bifidobacterium breve MCC1274 with human iPS-derived intestinal epithelial cells Open
Examining how host cells affect metabolic behaviors of probiotics is pivotal to better understand the mechanisms underlying the probiotic efficacy in vivo . However, studies to elucidate the interaction between probiotics and host cells, s…
View article: Substrate recognition mode of a glycoside hydrolase family 42 β-galactosidase from Bifidobacterium longum subspecies infantis(BiBga42A) revealed by crystallographic and mutational analyses
Substrate recognition mode of a glycoside hydrolase family 42 β-galactosidase from Bifidobacterium longum subspecies infantis(BiBga42A) revealed by crystallographic and mutational analyses Open
Aim:Bifidobacterium longum subsp. infantis uses a glycoside hydrolase (GH) family 42 β-galactosidase (BiBga42A) for hydrolyzing lacto-N-tetraose (LNT), which is the most abundant core structure of human milk oligosaccharides (HMOs). As suc…
View article: Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production
Gut bacterial aromatic amine production: aromatic amino acid decarboxylase and its effects on peripheral serotonin production Open
Colonic luminal aromatic amines have been historically considered to be derived from dietary source, especially fermented foods; however, recent studies indicate that the gut microbiota serves as an alternative source of these amines. Here…
View article: Dietary-protein sources modulate host susceptibility to Clostridioides difficile infection through the gut microbiota
Dietary-protein sources modulate host susceptibility to Clostridioides difficile infection through the gut microbiota Open
Clostridioides difficile causes nosocomial antibiotic-associated diarrhea on a global scale. Susceptibility to C. difficile infection (CDI) is influenced by the composition and metabolism of gut microbiota, which in turn are affected by di…
View article: Priority effects shape the structure of infant-type <i>Bifidobacterium</i> communities on human milk oligosaccharides
Priority effects shape the structure of infant-type <i>Bifidobacterium</i> communities on human milk oligosaccharides Open
Bifidobacteria are among the first colonizers of the infant gut, and human milk oligosaccharides (HMOs) in breastmilk are instrumental for the formation of a bifidobacteria-rich microbiota. However, little is known about the assembly of bi…
View article: Diversification of a Fucosyllactose Transporter within the Genus <i>Bifidobacterium</i>
Diversification of a Fucosyllactose Transporter within the Genus <i>Bifidobacterium</i> Open
Human milk oligosaccharides (HMOs), which are natural bifidogenic prebiotics, were recently commercialized to fortify formula milk. However, HMO assimilation phenotypes of bifidobacteria vary by species and strain, which has not been fully…
View article: A simple method that enhances minority species detection in the microbiota: 16S metagenome-DRIP (Deeper Resolution using an Inhibitory Primer)
A simple method that enhances minority species detection in the microbiota: 16S metagenome-DRIP (Deeper Resolution using an Inhibitory Primer) Open
Aim: 16S rRNA gene-based microbiota analyses (16S metagenomes) using next-generation sequencing (NGS) technologies are widely used to examine the microbial community composition in environmental samples. However, the sequencing capacity of…
View article: Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing <i>Clostridioides difficile</i>
Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing <i>Clostridioides difficile</i> Open
Certain existing prebiotics meant to facilitate the growth of beneficial bacteria in the intestine also promote the growth of other prominent bacteria. Therefore, the growth-promoting effects of β-galactosides on intestinal bacteria were a…
View article: Bifidobacterium bifidum Suppresses Gut Inflammation Caused by Repeated Antibiotic Disturbance Without Recovering Gut Microbiome Diversity in Mice
Bifidobacterium bifidum Suppresses Gut Inflammation Caused by Repeated Antibiotic Disturbance Without Recovering Gut Microbiome Diversity in Mice Open
The gut microbiome is a dynamic community that significantly affects host health; it is frequently disturbed by medications such as antibiotics. Recently, probiotics have been proposed as a remedy for antibiotic-induced dysbiosis, but the …
View article: Butyrate producing Clostridiales utilize distinct human milk oligosaccharides correlating to early colonization and prevalence in the human gut
Butyrate producing Clostridiales utilize distinct human milk oligosaccharides correlating to early colonization and prevalence in the human gut Open
The early life human gut microbiota exerts life-long health effects on the host, but the mechanisms underpinning its assembly remain elusive. Particularly, the early colonization of Clostridiales from the Roseburia-Eubacterium group, assoc…
View article: Enzymatic Adaptation of Bifidobacterium bifidum to Host Glycans, Viewed from Glycoside Hydrolyases and Carbohydrate-Binding Modules
Enzymatic Adaptation of Bifidobacterium bifidum to Host Glycans, Viewed from Glycoside Hydrolyases and Carbohydrate-Binding Modules Open
Certain species of the genus Bifidobacterium represent human symbionts. Many studies have shown that the establishment of symbiosis with such bifidobacterial species confers various beneficial effects on human health. Among the more than t…
View article: Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with Bifidobacteria-Rich Microbiota Formation
Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with Bifidobacteria-Rich Microbiota Formation Open
The infant’s gut microbiome is generally rich in the Bifidobacterium genus. The mother’s milk contains natural prebiotics, called human milk oligosaccharides (HMOs), as the third most abundant solid component after lactose and lipids, and …
View article: Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis
Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis Open
Human milk oligosaccharide transporters play key roles in symbiosis and coevolution between bifidobacteria and breast-fed infants.
View article: Minority species influences microbiota formation: the role of <i>Bifidobacterium</i> with extracellular glycosidases in bifidus flora formation in breastfed infant guts
Minority species influences microbiota formation: the role of <i>Bifidobacterium</i> with extracellular glycosidases in bifidus flora formation in breastfed infant guts Open
Summary The human body houses a variety of microbial ecosystems, such as the microbiotas on the skin, in the oral cavity and in the digestive tract. The gut microbiota is one such ecosystem that contains trillions of bacteria, and it is we…