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View article: DDEL-07. Blood-brain barrier disruption (BBBD) treatment is related to better survival in primary CNS lymphoma
DDEL-07. Blood-brain barrier disruption (BBBD) treatment is related to better survival in primary CNS lymphoma Open
INTRODUCTION Primary central nervous system lymphoma (PCNSL) is an aggressive malignancy affecting central nervous system (CNS). In treatment, blood-brain barrier (BBB) sets a challenge for chemoterapeutic penetration to CNS. A cornerstone…
View article: Nodal peripheral T‐cell lymphoma in Finland between 2007 and 2019: Incidence, late morbidity and survival
Nodal peripheral T‐cell lymphoma in Finland between 2007 and 2019: Incidence, late morbidity and survival Open
Summary Data on late morbidity and survival in nodal peripheral T‐cell lymphoma ( PTCL ) are scarce. This study investigated the incidence, subtype distribution, late morbidity and survival outcomes of nodal PTCL in Finland. The study comp…
View article: 298 | THE IMPACT OF SOCIOECONOMIC STATUS ON SURVIVAL OF PATIENTS WITH LARGE B‐CELL LYMPHOMA IN FINLAND, A POPULATION‐BASED ANALYSIS
298 | THE IMPACT OF SOCIOECONOMIC STATUS ON SURVIVAL OF PATIENTS WITH LARGE B‐CELL LYMPHOMA IN FINLAND, A POPULATION‐BASED ANALYSIS Open
View article: Poor survival of metastatic cancer patients hospitalized due to immune checkpoint inhibitor-related adverse events
Poor survival of metastatic cancer patients hospitalized due to immune checkpoint inhibitor-related adverse events Open
IrAE-related hospitalization deteriorated the survival of ICI-treated patients, likely due to decreased biological efficacy of ICIs resulting from short therapy periods and strong immunosuppression by glucocorticoids.
View article: Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity
Increased PD-1 expression in livers associated with PD-1-antibody-induced hepatotoxicity Open
View article: Increasing incidence and prevalence of Hodgkin’s lymphoma in Finland: a population-based registry study
Increasing incidence and prevalence of Hodgkin’s lymphoma in Finland: a population-based registry study Open
Hodgkin’s lymphoma (HL) is a lymphoid malignancy with an emphasized incidence in developed countries. This study aimed to assess the changes in the epidemiology of HL in Finland at the population level by utilizing data from six nationwide…
View article: Defining MRI-based follow-up protocol for primary central nervous system lymphoma
Defining MRI-based follow-up protocol for primary central nervous system lymphoma Open
Background The optimal follow-up protocol for primary central nervous system lymphoma (PCNSL) is unclear. This is the first study to evaluate the benefit of structured follow-up imaging of PCNSL with respect to the timing of relapse. Metho…
View article: Is there a role for structural MRI in PCNSL follow-up?
Is there a role for structural MRI in PCNSL follow-up? Open
Background The optimal follow-up protocol for primary central nervous system lymphoma (PCNSL) is unclear. This is the first study to evaluate the benefit of structured follow-up imaging of PCNSL with respect to the timing of relapse. Metho…
View article: 86P Treatment trajectories and outcome following irAE related hospitalization in metastatic cancer patients
86P Treatment trajectories and outcome following irAE related hospitalization in metastatic cancer patients Open
View article: Survival of patients with classical Hodgkin lymphoma in Finland: a national population-based analysis
Survival of patients with classical Hodgkin lymphoma in Finland: a national population-based analysis Open
View article: High Numbers of CD163+ Tumor-Associated Macrophages Predict Poor Prognosis in HER2+ Breast Cancer
High Numbers of CD163+ Tumor-Associated Macrophages Predict Poor Prognosis in HER2+ Breast Cancer Open
Tumor-associated macrophages (TAMs) are associated with a poor outcome in breast cancer (BC), but their prognostic value in different BC subtypes has remained somewhat unclear. Here, we investigated the prognostic value of M2-like TAMs (CD…
View article: A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors
A practical prognostic peripheral blood-based risk model for the evaluation of the likelihood of a response and survival of metastatic cancer patients treated with immune checkpoint inhibitors Open
Background Less than half of unselected metastatic cancer patients benefit from the immune checkpoint inhibitor (ICI) therapy. Systemic cancer-related inflammation may influence the efficacy of ICIs and thus, systemic inflammatory markers …
View article: Real-world Data: MCL2 Protocol Demonstrates Excellent Treatment Results Among Patients With Mantle Cell Lymphoma Not Fulfilling the Original Trial Inclusion Criteria
Real-world Data: MCL2 Protocol Demonstrates Excellent Treatment Results Among Patients With Mantle Cell Lymphoma Not Fulfilling the Original Trial Inclusion Criteria Open
Mantle cell lymphoma (MCL) is a rare and heterogeneous subgroup of B-cell lymphomas. The clinical course of MCL varies from an indolent form to an extremely aggressive phenotype. MCL is still an incurable disease. However, intensified chem…
View article: Rapid diagnosis and initiation of treatment has a crucial role in the prognosis of primary central nervous system lymphoma
Rapid diagnosis and initiation of treatment has a crucial role in the prognosis of primary central nervous system lymphoma Open
Primary central nervous system lymphoma (PCNSL) is a rare and aggressive Non-Hodgkin lymphoma. Diagnosis of PCNSL is challenging and non-specific symptoms can lead to a delay in the diagnosis. After successful therapy, patients have excell…
View article: Previous radiotherapy improves treatment responses and causes a trend toward longer time to progression among patients with immune checkpoint inhibitor-related adverse events
Previous radiotherapy improves treatment responses and causes a trend toward longer time to progression among patients with immune checkpoint inhibitor-related adverse events Open
View article: The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer
The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer Open
View article: LIFETIME TREATMENT BURDEN OF PATIENTS WITH MANTLE CELL LYMPHOMA: SIMULATION‐BASED ANALYSIS OF REAL‐WORLD DATA FROM 20 YEARS
LIFETIME TREATMENT BURDEN OF PATIENTS WITH MANTLE CELL LYMPHOMA: SIMULATION‐BASED ANALYSIS OF REAL‐WORLD DATA FROM 20 YEARS Open
Background: Mantle cell lymphoma (MCL) is a rare subtype of B-cell lymphoma that is currently considered incurable, yet treatable condition with increasing amount of treatment options. Alas, the availability of novel therapies is often lim…
View article: Blood–Brain Barrier Disruption (BBBD)-Based Immunochemotherapy for Primary Central Nervous System Lymphoma (PCNSL), Early Results of a Phase II Study
Blood–Brain Barrier Disruption (BBBD)-Based Immunochemotherapy for Primary Central Nervous System Lymphoma (PCNSL), Early Results of a Phase II Study Open
Primary central nervous system lymphoma is a rare but aggressive brain malignancy. It is associated with poor prognosis even with the current standard of care. The aim of this study was to evaluate the effect and tolerability of blood–brai…
View article: Antibiotic Treatment is an Independent Poor Risk Factor in NSCLC But Not in Melanoma Patients Who had Received Anti-PD-1/L1 Monotherapy
Antibiotic Treatment is an Independent Poor Risk Factor in NSCLC But Not in Melanoma Patients Who had Received Anti-PD-1/L1 Monotherapy Open
Early ABT was an independent poor risk factor in NSCLC patients who had received anti-PD-1/L1 monotherapy but not in melanoma patients. The weight of ABT as a poor risk factor might depend on other prognostic factors in different cancers.
View article: Survival of patients with mantle cell lymphoma in the rituximab era: Retrospective binational analysis between 2000 and 2020
Survival of patients with mantle cell lymphoma in the rituximab era: Retrospective binational analysis between 2000 and 2020 Open
Summary Mantle cell lymphoma (MCL) is a rare peripheral B‐cell lymphoma characterised by eventual relapse and progression towards a more aggressive disease biology. With the introduction of rituximab‐ and cytarabine‐based immunochemotherap…
View article: Risk factors of venous thromboembolic events among diffuse large B-cell lymphoma patients receiving first-line treatment
Risk factors of venous thromboembolic events among diffuse large B-cell lymphoma patients receiving first-line treatment Open
Venous thromboembolic events (VTEs) remain a major cause of mortality and morbidity among lymphoma patients. In this retrospective study, we analyzed the risk factors for VTEs in DLBCL (diffuse large B-cell lymphoma) patients treated with …
View article: Risk factors of venous thromboembolic events among diffuse large B-cell lymphoma patients receiving first-line treatment
Risk factors of venous thromboembolic events among diffuse large B-cell lymphoma patients receiving first-line treatment Open
Background Venous thromboembolic events (VTEs) remain a major cause of mortality and morbidity among lymphoma patients. Accurate risk-prediction models are lacking, however, especially in the high VTE risk subgroup of diffuse large B-cell …
View article: Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis
Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis Open
View article: The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma
The Impact of Hyaluronan on Tumor Progression in Cutaneous Melanoma Open
The incidence of cutaneous melanoma is rapidly increasing worldwide. Cutaneous melanoma is an aggressive type of skin cancer, which originates from malignant transformation of pigment producing melanocytes. The main risk factor for melanom…
View article: Primary Central Nervous System Lymphoma High Incidence And Poor Survival In Finnish Population-Based Analysis
Primary Central Nervous System Lymphoma High Incidence And Poor Survival In Finnish Population-Based Analysis Open
Background: We report here the first population-based incidence rates and prognosis of primary central nervous system lymphoma (PCNSL) in Finland. Methods: Finnish Cancer Registry data by histological diagnosis and tumor location (2007-201…
View article: Primary Central Nervous System Lymphoma Increasing Incidence and Poor Survival: A Finnish Population-based Analysis
Primary Central Nervous System Lymphoma Increasing Incidence and Poor Survival: A Finnish Population-based Analysis Open
PurposeWe report here the first population-based incidence rates and prognosis of primary central nervous system lymphoma (PCNSL) in Finland. MethodsFinnish Cancer Registry data by histological diagnosis and tumor location (2007-2017) for …
View article: Human T cell responses to dog lipocalin allergens : prospects for allergen immunotherapy
Human T cell responses to dog lipocalin allergens : prospects for allergen immunotherapy Open