Aiqi Zhao
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View article: Targeting triple-negative breast cancer using cord-blood CD34⁺ HSPC-derived mesothelin-specific CAR-NKT cells with potent antitumor activity
Targeting triple-negative breast cancer using cord-blood CD34⁺ HSPC-derived mesothelin-specific CAR-NKT cells with potent antitumor activity Open
View article: Allogeneic stem cell-engineered EGFRvIII-specific CAR-NKT cells for treating glioblastoma with enhanced efficacy and safety
Allogeneic stem cell-engineered EGFRvIII-specific CAR-NKT cells for treating glioblastoma with enhanced efficacy and safety Open
Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor in adults, characterized by resistance to standard therapies, including surgical resection, radiation, chemotherapy, and targeted agents. While chimeric antigen recep…
View article: Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells
Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells Open
Renal cell carcinoma (RCC) represents about 90% of kidney cancers, with 30%-40% of patients developing metastatic disease despite current treatments. Conventional chimeric antigen receptor (CAR)-T therapy targeting CD70 shows promise but f…
View article: MAZ Coordinates With HDAC1 to Promote Hepatocarcinoma Proliferation and Metastasis Through Transcriptional Repression of CSK
MAZ Coordinates With HDAC1 to Promote Hepatocarcinoma Proliferation and Metastasis Through Transcriptional Repression of CSK Open
The transcription factor Myc‐associated zinc finger protein (MAZ) is highly expressed in various malignant tumors, and it is known to activate the expression of a large number of proto‐oncogenes through transcription. However, the specific…
View article: Tendomodulin in pan-cancer analysis: exploring its impact on immune modulation and uncovering functional insights in colorectal cancer
Tendomodulin in pan-cancer analysis: exploring its impact on immune modulation and uncovering functional insights in colorectal cancer Open
Our findings reveal a critical immunomodulatory role of TNMD in CRC, particularly in influencing tumor-immune interactions. Beyond its potential diagnostic and prognostic biomarker, TNMD promotes CRC metastasis and invasion, thus emerging …
View article: Convolutional Recurrent Neural Networks with a Self-Attention Mechanism for Personnel Performance Prediction
Convolutional Recurrent Neural Networks with a Self-Attention Mechanism for Personnel Performance Prediction Open
Personnel performance is important for the high-technology industry to ensure its core competitive advantages are present. Therefore, predicting personnel performance is an important research area in human resource management (HRM). In thi…
View article: Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease
Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease Open
Background: As a hallmark driver of multiple myeloma (MM), MM bone disease (MBD) is unique in that it is characterized by severely impaired osteoblast activity resulting from blocked osteogenesis in bone marrow-derived mesenchymal s…
View article: Selective surface marker and miRNA profiles of CD34+ blast-derived microvesicles in chronic myelogenous leukemia
Selective surface marker and miRNA profiles of CD34+ blast-derived microvesicles in chronic myelogenous leukemia Open
The present study aimed at investigating the selective enrichment of surface marker and functional microRNA (miRNA) profiles of cluster of differentiation (CD)34+ blast-derived microvesicles (MVs) from parental cells in chronic …
View article: Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities
Extracellular Vesicle-functionalized Decalcified Bone Matrix Scaffolds with Enhanced Pro-angiogenic and Pro-bone Regeneration Activities Open
Vascularization is crucial for bone regeneration after the transplantation of tissue-engineered bone grafts in the clinical setting. Growing evidence suggests that mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are potent…
View article: Tumor Cell-Derived Microvesicles Induced Not Epithelial-Mesenchymal Transition but Apoptosis in Human Proximal Tubular (HK-2) Cells: Implications for Renal Impairment in Multiple Myeloma
Tumor Cell-Derived Microvesicles Induced Not Epithelial-Mesenchymal Transition but Apoptosis in Human Proximal Tubular (HK-2) Cells: Implications for Renal Impairment in Multiple Myeloma Open
Renal impairment (RI) is one of the hallmarks of multiple myeloma (MM) and carries a poor prognosis. Microvesicles (MVs) are membrane vesicles and play an important role in disease progression. Here, we investigated the role of MVs derived…
View article: Microvesicles as Potential Biomarkers for the Identification of Senescence in Human Mesenchymal Stem Cells
Microvesicles as Potential Biomarkers for the Identification of Senescence in Human Mesenchymal Stem Cells Open
Senescence in human mesenchymal stem cells (MSCs) not only contributes to organism aging and the development of a variety of diseases but also severely impairs their therapeutic properties as a promising cell therapy. Studies searching for…
View article: Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications
Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications Open
One of the major challenges of bone tissue engineering applications is to construct a fully vascularized implant that can adapt to hypoxic environments in vivo. The incorporation of proangiogenic factors into scaffolds is a widely accepted…
View article: Mesenchymal Stem Cell‐Derived Microvesicles Support Ex Vivo Expansion of Cord Blood‐Derived CD34<sup>+</sup> Cells
Mesenchymal Stem Cell‐Derived Microvesicles Support Ex Vivo Expansion of Cord Blood‐Derived CD34<sup>+</sup> Cells Open
Mesenchymal stem cells (MSCs) are known to support the characteristic properties of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow hematopoietic microenvironment. MSCs are used in coculture systems as a feeder layer for…