Airah Javorsky
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View article: Viral manipulation of cell polarity signalling
Viral manipulation of cell polarity signalling Open
Cell polarity refers to the asymmetric distribution of biomacromolecules that enable the correct orientation of a cell in a particular direction. It is thus an essential component for appropriate tissue development and function. Viral infe…
View article: Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1
Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1 Open
View article: Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis
Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis Open
G protein-coupled receptors, including PTHR, are pivotal for controlling metabolic processes ranging from serum phosphate and vitamin D levels to glucose uptake, and cytoplasmic interactors may modulate their signaling, trafficking, and fu…
View article: The cell adhesion receptor TMIGD1 recruits Scribble to the basolateral membrane via direct interaction
The cell adhesion receptor TMIGD1 recruits Scribble to the basolateral membrane via direct interaction Open
Scribble (Scrib) is a multidomain polarity protein and member of the leucine-rich repeat (LRR) and PDZ domain (LAP) protein family. A loss of Scrib expression is associated with disturbed apical-basal polarity and tumor formation. The tumo…
View article: Viral subversion of the cell polarity regulator Scribble
Viral subversion of the cell polarity regulator Scribble Open
Scribble is a scaffolding protein that regulates key events such as cell polarity, tumorigenesis and neuronal signalling. Scribble belongs to the LAP family which comprise of 16 Leucine Rich Repeats (LRR) at the N-terminus, two LAP Specifi…
View article: Structural insight into the Scribble<scp>PDZ</scp>domains interaction with the oncogenic Human T‐cell lymphotrophic virus‐1 (<scp>HTLV</scp>‐1) Tax1<scp>PBM</scp>
Structural insight into the Scribble<span>PDZ</span>domains interaction with the oncogenic Human T‐cell lymphotrophic virus‐1 (<span>HTLV</span>‐1) Tax1<span>PBM</span> Open
Scribble (Scrib) is a highly conserved cell polarity regulator that harbours potent tumour suppressor activity and plays an important role in cell migration. Dysregulation of polarity is associated with poor prognosis during viral infectio…
View article: Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling
Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling Open
The Scribble (Scrib) protein is a conserved cell polarity regulator with anti-tumorigenic properties. Viruses like the Tick-born encephalitis virus (TBEV) target Scribble to establish a cellular environment supporting viral replication, wh…
View article: Structural Basis of the Avian Influenza NS1 Protein Interactions with the Cell Polarity Regulator Scribble
Structural Basis of the Avian Influenza NS1 Protein Interactions with the Cell Polarity Regulator Scribble Open
Scribble is a highly conserved regulator of cell polarity, a process that enables the generation of asymmetry at the cellular and tissue level in higher organisms. Scribble acts in concert with Disc-large (Dlg) and Lethal-2-giant larvae (L…
View article: Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain Open
SARS-CoV-2 infection leads to coronavirus disease 2019 (COVID-19), which is associated with severe and life-threatening pneumonia and respiratory failure. However, the molecular basis of these symptoms remains unclear. SARS-CoV-1 E protein…
View article: Structural insight into tanapoxvirus‐mediated inhibition of apoptosis
Structural insight into tanapoxvirus‐mediated inhibition of apoptosis Open
Premature programmed cell death or apoptosis of cells is a strategy utilized by multicellular organisms to counter microbial threats. Tanapoxvirus (TANV) is a large double‐stranded DNA virus belonging to the poxviridae that causes mild mon…
View article: Structural insight into tanapoxvirus mediated inhibition of apoptosis
Structural insight into tanapoxvirus mediated inhibition of apoptosis Open
Premature programmed cell death or apoptosis of cells is a strategy utilized by multicellular organisms to counter microbial threats. Tanapoxvirus (TANV) is a large double-stranded DNA virus belonging to the poxviridae that causes mild Mon…