Aishath Naeem
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View article: Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain
Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain Open
View article: Mutations Detected in Real World Clinical Sequencing during BTK Inhibitor Treatment in CLL
Mutations Detected in Real World Clinical Sequencing during BTK Inhibitor Treatment in CLL Open
We retrospectively analyzed 609 chronic lymphocytic leukemia (CLL) patients treated with BTK inhibitors (BTKis) at Dana-Farber Cancer Institute from 2014 to 2022. Among them, 85 underwent next-generation sequencing (NGS) during or after BT…
View article: Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples
Genetic events associated with venetoclax resistance in CLL identified by whole-exome sequencing of patient samples Open
Although BCL2 mutations are reported as later occurring events leading to venetoclax resistance, many other mechanisms of progression have been reported though remain poorly understood. Here, we analyze longitudinal tumor samples from 11 p…
View article: Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance
Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance Open
Covalent inhibitors of Bruton tyrosine kinase (BTK) have transformed the therapy of chronic lymphocytic leukemia (CLL), but continuous therapy has been complicated by the development of resistance. The most common resistance mechanism in p…
View article: Activation of the MAPK pathway mediates resistance to PI3K inhibitors in chronic lymphocytic leukemia
Activation of the MAPK pathway mediates resistance to PI3K inhibitors in chronic lymphocytic leukemia Open
Inhibitors of Bruton tyrosine kinase (BTK) and phosphatidylinositol 3-kinase δ (PI3Kδ) that target the B-cell receptor (BCR) signaling pathway have revolutionized the treatment of chronic lymphocytic leukemia (CLL). Mutations associated wi…
View article: Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin
Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin Open
View article: Orchestrated control of filaggrin–actin scaffolds underpins cornification
Orchestrated control of filaggrin–actin scaffolds underpins cornification Open
View article: A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis Open
Our findings highlight a novel and potentially treatable signaling axis controlling filaggrin expression and processing that is defective in patients with AD.
View article: AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation
AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation Open