Aishlin Hassan
YOU?
Author Swipe
View article: The impact of donor and recipient age on post-transplantation clonality in murine hematopoiesis
The impact of donor and recipient age on post-transplantation clonality in murine hematopoiesis Open
Introduction The sustained production of blood and immune cells is driven by a pool of hematopoietic stem cells (HSCs) and their offspring. Due to the intrinsic heterogeneity of HSCs, the composition of emergent clones changes over time, l…
View article: Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization
Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization Open
IRAK4 is a therapeutic target in myeloid malignancies, but current IRAK4 inhibitors show only modest clinical efficacy in acute myeloid leukemia, highlighting the need for combination strategies. To identify drugs with synergistic potentia…
View article: Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis
Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis Open
View article: Additional Cover
Additional Cover Open
Cover legend: The cover image is based on the Article Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged HSCs upon pH treatment by Sachin Kumar et al., https://doi.org/10.1111/acel.14324 [Image: see text]
View article: Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged <scp>HSCs</scp> upon <scp>pH</scp> treatment
Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged <span>HSCs</span> upon <span>pH</span> treatment Open
Aged hematopoietic stem cells (HSCs) show reduced reconstitution potential, limiting their use in transplantation settings in the clinic. We demonstrate here that exposure of aged HSCs ex vivo to a pH of 6.9 instead of the commonly used pH…
View article: <scp>pH</scp> regulates hematopoietic stem cell potential via polyamines
<span>pH</span> regulates hematopoietic stem cell potential via polyamines Open
View article: Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis
Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis Open
The regeneration potential of the mammalian heart is incredibly limited, as cardiomyocyte proliferation ceases shortly after birth. β-adrenergic receptor (β-AR) blockade has been shown to improve heart functions in response to injury; howe…
View article: Author response: Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis
Author response: Inhibition of β1-AR/Gαs signaling promotes cardiomyocyte proliferation in juvenile mice through activation of RhoA-YAP axis Open
View article: Inhibition of adrenergic β1-AR/Gαs signaling promotes cardiomyocyte proliferation through activation of RhoA-YAP axis
Inhibition of adrenergic β1-AR/Gαs signaling promotes cardiomyocyte proliferation through activation of RhoA-YAP axis Open
The regeneration potential of the mammalian heart is incredibly limited, as cardiomyocyte proliferation ceases shortly after birth. β-adrenergic receptor (β-AR) blockade has been shown to improve heart functions in response to injury; howe…
View article: Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells
Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells Open
View article: Repolarization of HSC attenuates HSCs failure in Shwachman–Diamond syndrome
Repolarization of HSC attenuates HSCs failure in Shwachman–Diamond syndrome Open
View article: YAP/TAZ-CDC42 signaling regulates vascular tip cell migration
YAP/TAZ-CDC42 signaling regulates vascular tip cell migration Open
Significance New blood vessel formation is a physiological process seen in development, as well as in wound healing and tumorigenesis. Although the process of blood vasculature formation has been well documented, little is known about the …
View article: Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch
Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch Open
View article: Inhibition of cerebral vascular inflammation by brain endothelium-targeted oligodeoxynucleotide complex
Inhibition of cerebral vascular inflammation by brain endothelium-targeted oligodeoxynucleotide complex Open
View article: Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch
Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch Open