Aisling A. Garvey
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View article: Machine learning models of cerebral oxygenation (rcSO<sub>2</sub>) for brain injury detection in neonates with hypoxic‐ischaemic encephalopathy
Machine learning models of cerebral oxygenation (rcSO<sub>2</sub>) for brain injury detection in neonates with hypoxic‐ischaemic encephalopathy Open
The present study was designed to test the potential utility of regional cerebral oxygen saturation (rcSO 2 ) in detecting term infants with brain injury. The study also examined whether quantitative rcSO 2 features are associated with gra…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc.
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical, etc. Open
BACKGROUND AND OBJECTIVE: Preterm neonates with intraventricular hemorrhage (IVH) are at risk for posthemorrhagic ventricular dilatation (PHVD).In recent years targeted proteomics has developed into a powerful protein quantifi cation tool …
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring Open
Preterm children are at risk for language development delays. Early shared reading has been demonstrated to enhance language development and functional brain connectivity in full-term
\nchildren. Therefore, recent research examines the pot…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuroprotection strategies in the neonate
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuroprotection strategies in the neonate Open
BACKGROUND: Cerebral intraventricular hemorrhage (IVH) is a major cause of neurodevelopmental impairment in preterm infants.IVH is characterized by vessel rupture and a rapid accumulation of blood within the ventricles.Subsequent hemolysis…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuro-imaging studies
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Neuro-imaging studies Open
BACKGROUND: Hypoxic Ischemic Encephalopathy (HIE) is a signifi cant cause of perinatal encephalopathy, affecting a substantial number of neonates.Therapeutic hypothermia (TH) has become a standard treatment, signifi cantly reducing mortali…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology Open
BACKGROUND: Preterm birth is associated with significant risks for long-term impairments in brain structure and cognitive functions (1). At the microscopic level, the transient inflammatory and hypoxic-ischemic events occurring during prem…
View article: Management of neonatal hypoglycaemia in a tertiary maternity unit—A multidisciplinary quality improvement project
Management of neonatal hypoglycaemia in a tertiary maternity unit—A multidisciplinary quality improvement project Open
Aim Improved identification and treatment of infants at risk of hypoglycaemia using evidence‐based guidelines. Methods Design: Prospective, multidisciplinary quality improvement project (QIP). Setting: Tertiary maternity hospital, Dublin (…
View article: Proceedings of the 14<sup>th</sup> International Newborn Brain Conference: Neuro-imaging studies
Proceedings of the 14<sup>th</sup> International Newborn Brain Conference: Neuro-imaging studies Open
BACKGROUND: Cardiorespiratory deterioration is common in very low birth weight (<1500g) infants.This period of critical brain growth and development may be impacted by insults such as sepsis and hypoxia.The physiological response to illnes…
View article: Serum Alanine Levels in Perinatal Asphyxia and Neonatal Hypoxic-Ischaemic Encephalopathy
Serum Alanine Levels in Perinatal Asphyxia and Neonatal Hypoxic-Ischaemic Encephalopathy Open
The authors have requested that this preprint be removed from Research Square.
View article: Brain Injury in Infants Evaluated for, But Not Treated with, Therapeutic Hypothermia
Brain Injury in Infants Evaluated for, But Not Treated with, Therapeutic Hypothermia Open
Defining neonatal encephalopathy clinically to qualify for therapeutic hypothermia is challenging. This study examines magnetic resonance imaging outcomes of 39 infants who were evaluated and not cooled using criteria inclusive of mild enc…
View article: Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy
Non-invasive continuous cardiac output monitoring in infants with hypoxic ischaemic encephalopathy Open
Objective To describe early, continuous, non-invasive measures of cardiac output (CO) and evolution over time in infants with hypoxic-ischaemic encephalopathy (HIE). Study design Prospective observational study of 44 infants with HIE (23 m…
View article: Evolution of early cerebral <scp>NIRS</scp> in hypoxic ischaemic encephalopathy
Evolution of early cerebral <span>NIRS</span> in hypoxic ischaemic encephalopathy Open
Aim To describe early cerebral oxygenation (cSO 2 ) and fractional tissue oxygen extraction (FTOE) values and their evolution over the first days of life in infants with all grades of hypoxic‐ischaemic encephalopathy (HIE) and to determine…
View article: Proceedings of the 13th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical
Proceedings of the 13th International Newborn Brain Conference: Other forms of brain monitoring, such as NIRS, fMRI, biochemical Open
Hypoxic ischaemic encephalopathy (HIE), an important complication of perinatal asphyxia, remains a major health burden.Neonates are classifi ed using the Sarnat score and neonates >35 weeks with moderate/ severe HIE are treated with therap…
View article: Does Early Cerebral Near-Infrared Spectroscopy Monitoring Predict Outcome in Neonates with Hypoxic Ischaemic Encephalopathy? A Systematic Review of Diagnostic Test Accuracy
Does Early Cerebral Near-Infrared Spectroscopy Monitoring Predict Outcome in Neonates with Hypoxic Ischaemic Encephalopathy? A Systematic Review of Diagnostic Test Accuracy Open
Introduction: Hypoxic ischaemic encephalopathy (HIE) remains one of the top 10 contributors to the global burden of disease. Early objective biomarkers are required. Near-infrared spectroscopy (NIRS) may provide a valuable insight into cer…
View article: Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides
Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides Open
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, ma…
View article: Non-invasive Cardiac Output Monitoring in Neonates
Non-invasive Cardiac Output Monitoring in Neonates Open
Circulatory monitoring is currently limited to heart rate and blood pressure assessment in the majority of neonatal units globally. Non-invasive cardiac output monitoring (NiCO) in term and preterm neonates is increasing, where it has the …
View article: Simulation in Neonatal Resuscitation
Simulation in Neonatal Resuscitation Open
Approximately 1 in 10 newborns will require basic resuscitation interventions at birth. Some infants progress to require more advanced measures including the provision of positive pressure ventilation, chest compressions, intubation and ad…
View article: OC59 Multimodal monitoring as predictor of brain injury in the preterm infant
OC59 Multimodal monitoring as predictor of brain injury in the preterm infant Open
Background Cerebral auto-regulation(CAR) in the preterm infant is a complex, multi-factorial process which is still poorly characterised in very preterm infants. It plays a substantial role in the aetiology of intraventricular haemorrhage …
View article: GP251 Is heart rate variability (HRV) a predictor of intraventricular haemorrhage (IVH) in preterm infants?
GP251 Is heart rate variability (HRV) a predictor of intraventricular haemorrhage (IVH) in preterm infants? Open
Introduction Intraventricular haemorrhage (IVH) occurs in up to 15–20% of babies born before 32 weeks, and up to 30% in babies less than 28 weeks gestation. Injury can cause detrimental short and long-term health outcomes. Heart rate varia…
View article: GP293 Developing MARSIPAN integrated care pathways for children and adolescents with eating disorders- real world challenges and recommendations
GP293 Developing MARSIPAN integrated care pathways for children and adolescents with eating disorders- real world challenges and recommendations Open
Background Anorexia Nervosa has the highest rate of mortality and morbidity of the mental health conditions. Much of this is related to the physical consequences of starvation and can lead to medical admissions. Integrated care pathways ha…
View article: Interpretation of Cerebral Oxygenation Changes in the Preterm Infant
Interpretation of Cerebral Oxygenation Changes in the Preterm Infant Open
Near-infrared spectroscopy (NIRS) allows for continuous, non-invasive monitoring of end-organ tissue oxygenation. The use of NIRS, cerebral NIRS (cNIRS) in particular, in neonatal care has increased significantly over the last few years. T…
View article: Inotropes for Preterm Infants: 50 Years on Are We Any Wiser?
Inotropes for Preterm Infants: 50 Years on Are We Any Wiser? Open
For almost half a century, inotropes have been administered to preterm infants with the ultimate goal of increasing their blood pressure. A number of trials, the majority of which focused on dopamine administration, have demonstrated incre…
View article: Youngest survivor of perinatal infection by Eikenella corrodens : case analysis and literature review highlighting the merits of placental swab culture
Youngest survivor of perinatal infection by Eikenella corrodens : case analysis and literature review highlighting the merits of placental swab culture Open
Eikenella corrodens has been noted as a causative organism in both neonatal and perinatal sepsis. Positivity of blood cultures at birth among preterm infants may be influenced by the maternal use of peripartum antimicrobials and a normal C…