Aisling McFall
YOU?
Author Swipe
View article: Optical, contact-free assessment of brain tissue stiffness and neurodegeneration
Optical, contact-free assessment of brain tissue stiffness and neurodegeneration Open
Dementia affects a large proportion of the world’s population. Approaches that allow for early disease detection and non-invasive monitoring of disease progression are desperately needed. Current approaches are centred on costly imaging te…
View article: Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: A post hoc analysis
Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: A post hoc analysis Open
Ischaemic stroke presents a significant problem worldwide with no neuroprotective drugs available. Many of the failures in the search for neuroprotectants are attributed to failure to translate from pre-clinical models to humans, which has…
View article: Experimental and theoretical investigation of drotaverine binding to bovine serum albumin
Experimental and theoretical investigation of drotaverine binding to bovine serum albumin Open
This study was motivated by the need to provide more insight into the possible mechanism of the intermolecular interactions between antispasmodic drug drotaverine and one of the serum albumins (BSA), with the aim to indicate the most proba…
View article: Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins
Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins Open
Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of protein intermediates within the cAMP signaling pathway underpins receptor-specific respons…
View article: UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings
UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings Open
Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying vari…
View article: Modulating the counter-regulatory renin angiotensin system axis in experimental ischaemic stroke
Modulating the counter-regulatory renin angiotensin system axis in experimental ischaemic stroke Open
Stroke is a leading cause of death and disability worldwide, yet treatment options are limited. Stroke can be caused by a ruptured cerebral blood vessel, known as haemorrhagic stroke, or more commonly by the blockage of a blood vessel with…
View article: Altered Extracellular Vesicle MicroRNA Expression in Ischemic Stroke and Small Vessel Disease
Altered Extracellular Vesicle MicroRNA Expression in Ischemic Stroke and Small Vessel Disease Open
Active transport of microRNAs (miRNA) in extracellular vesicles (EV) occurs in disease. Circulating EV-packaged miRNAs in the serum of stroke patients were compared to stroke mimics with matched cardio- and cerebrovascular risk factors, wi…
View article: Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications
Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications Open
Galactokinase catalyses the site‐ and stereospecific phosphorylation of α‐ d ‐galactose. As such it has attracted interest as a biocatalyst for the introduction of phosphate groups into monosaccharides. However, attempts to broaden the sub…
View article: 9 Investigating the counter regulatory renin angiotensin system axis in the stroke prone spontaneously hypertensive rat in ischaemic stroke
9 Investigating the counter regulatory renin angiotensin system axis in the stroke prone spontaneously hypertensive rat in ischaemic stroke Open
Several studies have assessed the potential of targeting the renin angiotensin system (RAS) with therapeutics for ischaemic stroke. The counter regulatory RAS peptide, angiotensin-(1–9) has been shown to act via the angiotensin II type 2 r…