Aiying Chen
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View article: Ta-Doping Induced Strengthening in Feconial-Based High-Entropy Alloy Via Heterogeneous Dual-Phase Structure
Ta-Doping Induced Strengthening in Feconial-Based High-Entropy Alloy Via Heterogeneous Dual-Phase Structure Open
View article: Liu-Shen-Wan inhibits PI3K/Akt and TRPV1 signaling alleviating bone cancer pain in rats
Liu-Shen-Wan inhibits PI3K/Akt and TRPV1 signaling alleviating bone cancer pain in rats Open
Patients with advanced-stage cancers often suffer from severe pain caused by bone metastasis and destruction, for which effective treatment options are limited. Liu-Shen-Wan (LSW) is a widely recognized herbal formula utilized for pain rel…
View article: Static and dynamic mechanical behavior of high-strength 22SiMn2TiB armor steel and welded structure
Static and dynamic mechanical behavior of high-strength 22SiMn2TiB armor steel and welded structure Open
High-strength advanced steel and welded structure are key for service safety and life. Static and dynamic compressive mechanical behavior of high-strength 22SiMn2TiB armor steel and welded structure is investigated, which are carried out b…
View article: Efficacy and safety of the combination of paclitaxel, cisplatin and bevacizumab for the treatment of non-small cell lung cancer
Efficacy and safety of the combination of paclitaxel, cisplatin and bevacizumab for the treatment of non-small cell lung cancer Open
Purpose: To investigate the efficacy and safety of the combined use of paclitaxel, cisplatin, and bevacizumab for the treatment of non-small cell lung cancer (NSCLC). Methods: 98 NSCLC patients who received therapy at Hainan Hospital of Tr…
View article: Ta-Doping Induced Strengthening in Feconial-Based High-Entropy Alloy Via Heterogeneous Dual-Phase Structure
Ta-Doping Induced Strengthening in Feconial-Based High-Entropy Alloy Via Heterogeneous Dual-Phase Structure Open
View article: Multi-Step Phase-Transformation of Ni-Mn-Ga Smart Microwires Under Stress- and Strain-Controlled Tensile Modes
Multi-Step Phase-Transformation of Ni-Mn-Ga Smart Microwires Under Stress- and Strain-Controlled Tensile Modes Open
View article: Structured Benefit-Risk Assessment of a New Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Individuals Ages 12 Months and Older
Structured Benefit-Risk Assessment of a New Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Individuals Ages 12 Months and Older Open
View article: Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, parallel, randomised, modified double-blind, placebo-controlled trial
Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, parallel, randomised, modified double-blind, placebo-controlled trial Open
View article: Efficacy of a monovalent (D614) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, multi-country study
Efficacy of a monovalent (D614) SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in adults: a phase 3, multi-country study Open
View article: Twin-induced transformation strengthening of CoCrNi-based medium-entropy alloy with a gradient nanostructure
Twin-induced transformation strengthening of CoCrNi-based medium-entropy alloy with a gradient nanostructure Open
Single-phase face-centered cubic (fcc) medium-entropy alloys (MEAs) generally exhibit good ductility but insufficient room temperature strength that limits their potential application. Here, a deformation mechanism of twin-induced transfor…
View article: Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1A pathway
Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1A pathway Open
Metabolic reprogramming is a common phenomenon in cancer, with aerobic glycolysis being one of its important characteristics. Hypoxia-inducible factor-1α (HIF1Α) is thought to play an important role in aerobic glycolysis. Meanwhile,…
View article: Enhance the Elongation of Quenched Fe-6.5wt%Si Alloy by Adjusting Ordered Phases and Residual Stress
Enhance the Elongation of Quenched Fe-6.5wt%Si Alloy by Adjusting Ordered Phases and Residual Stress Open
View article: Ultralow-iridium content NiIr alloy derivative nanochain arrays as bifunctional electrocatalysts for overall water splitting
Ultralow-iridium content NiIr alloy derivative nanochain arrays as bifunctional electrocatalysts for overall water splitting Open
An ultralow-iridium content nickel–iridium alloy derivative nanochain array with a self-supported three-dimensional core–shell structure for efficient and durable overall water splitting.
View article: Ta-Induced Strengthening of Cocrni-Alti Medium-Entropy Alloys Via Nanoscale Heterogeneous Coherent Precipitate
Ta-Induced Strengthening of Cocrni-Alti Medium-Entropy Alloys Via Nanoscale Heterogeneous Coherent Precipitate Open
View article: Formation and Effect of Hierarchical Structures on Corrosion Performance Ofstainless Steel Bipolar Plate Fabricated by Powder Bed Fusion
Formation and Effect of Hierarchical Structures on Corrosion Performance Ofstainless Steel Bipolar Plate Fabricated by Powder Bed Fusion Open
View article: Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 Protein Vaccine
Efficacy of a bivalent (D614 + B.1.351) SARS-CoV-2 Protein Vaccine Open
Background COVID-19 vaccines with alternative strain compositions are needed to provide broad protection against newly emergent SARS-CoV-2 variants of concern. Methods We conducted a global Phase 3, multi-stage efficacy study ( NCT04904549…
View article: Corrosion Behavior and Biocompatibility of Na2EDTA-Induced Nacre Coatings on AZ91D Alloys Prepared via Hydrothermal Treatment
Corrosion Behavior and Biocompatibility of Na2EDTA-Induced Nacre Coatings on AZ91D Alloys Prepared via Hydrothermal Treatment Open
An effective method for controlling the corrosion rate of Mg-based implants must be urgently developed to meet the requirements of clinical applications. As a naturally occurring osteoid material, nacre offers a strategy to endow biomedica…
View article: Formation and Effect of Hierarchical Structures on Corrosion Performance of Stainless Steel Bipolar Plate Fabricated by Powder Bed Fusion
Formation and Effect of Hierarchical Structures on Corrosion Performance of Stainless Steel Bipolar Plate Fabricated by Powder Bed Fusion Open
View article: Dual-Purpose Nickel-Iron Layered Double Hydroxides by Controlled Lanthanide and Phosphide Incorporation for Promoting Overall Water Splitting Efficiency
Dual-Purpose Nickel-Iron Layered Double Hydroxides by Controlled Lanthanide and Phosphide Incorporation for Promoting Overall Water Splitting Efficiency Open
View article: Er Single Atoms Decorated Tio2 and Er3+ Ions Modified Tio2 for Photocatalytic Oxidation of Mixed Vocs
Er Single Atoms Decorated Tio2 and Er3+ Ions Modified Tio2 for Photocatalytic Oxidation of Mixed Vocs Open
View article: Safety and immunogenicity of a SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in healthy adults: interim findings from a phase 2, randomised, dose-finding, multi-centre study
Safety and immunogenicity of a SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant in healthy adults: interim findings from a phase 2, randomised, dose-finding, multi-centre study Open
Summary Background This study evaluated the safety and immunogenicity of an AS03-adjuvanted SARS-CoV-2 recombinant protein candidate vaccine, CoV2 preS dTM. Methods This Phase 2, modified double-blind, parallel-group study ( NCT04762680 ) …
View article: Ductile behavior and excellent corrosion resistance of Mg-Zn-Yb-Ag metallic glasses
Ductile behavior and excellent corrosion resistance of Mg-Zn-Yb-Ag metallic glasses Open
Magnesium-based metal glasses (MMGs) have broad application potential as bio-implant materials because of their disordered atomic structure, fine degradability, low elasticity modulus, and high strength. However, their low plasticity and p…
View article: Microstructure Evolution and Mechanical Properties of Austenite Stainless Steel with Gradient Twinned Structure by Surface Mechanical Attrition Treatment
Microstructure Evolution and Mechanical Properties of Austenite Stainless Steel with Gradient Twinned Structure by Surface Mechanical Attrition Treatment Open
Gradient structures in engineering materials produce an impressive synergy of strength and plasticity, thereafter, have recently attracted extensive attention in the material families. Gradient structured stainless steels (SS) were prepare…
View article: Corrosion protection investigations of carbon dots and polydopamine composite coating on magnesium alloy
Corrosion protection investigations of carbon dots and polydopamine composite coating on magnesium alloy Open
View article: 1243. Semi-Quantitative Benefit-Risk Assessment for a New Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Individuals 2 Years of Age and Older
1243. Semi-Quantitative Benefit-Risk Assessment for a New Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Individuals 2 Years of Age and Older Open
Background MenACYW-TT is a new quadrivalent meningococcal conjugate vaccine approved by the US FDA for use in individuals 2 years and older. We present the structured benefit-risk assessment conducted by Sanofi Pasteur in support of the in…
View article: A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study of a Replication-Defective Herpes Simplex Virus (HSV) Type 2 Vaccine, HSV529, in Adults With or Without HSV Infection
A Randomized, Double-Blinded, Placebo-Controlled, Phase 1 Study of a Replication-Defective Herpes Simplex Virus (HSV) Type 2 Vaccine, HSV529, in Adults With or Without HSV Infection Open
Background Herpes simplex virus 2 (HSV2) causes genital herpes in >400 million persons worldwide. Methods We conducted a randomized, double-blinded, placebo-controlled trial of a replication-defective HSV2 vaccine, HSV529. Twenty adults we…
View article: Scale law of complex deformation transitions of nanotwins in stainless steel
Scale law of complex deformation transitions of nanotwins in stainless steel Open
Understanding the deformation behavior of metallic materials containing nanotwins (NTs), which can enhance both strength and ductility, is useful for tailoring microstructures at the micro- and nano- scale to enhance mechanical properties.…
View article: Microstructures-based constitutive analysis for mechanical properties of gradient-nanostructured 304 stainless steels
Microstructures-based constitutive analysis for mechanical properties of gradient-nanostructured 304 stainless steels Open
View article: A Replication-Defective Herpes Simplex Virus (HSV)-2 Vaccine, HSV529, is Safe and Well-Tolerated in Adults with or without HSV Infection and Induces Significant HSV-2-Specific Antibody Responses in HSV Seronegative Individuals
A Replication-Defective Herpes Simplex Virus (HSV)-2 Vaccine, HSV529, is Safe and Well-Tolerated in Adults with or without HSV Infection and Induces Significant HSV-2-Specific Antibody Responses in HSV Seronegative Individuals Open
Background We conducted a phase 1, randomized, double-blind, placebo-controlled trial of a replication-defective HSV-2 vaccine, HSV529 (deleted for UL5 and UL29), in 60 healthy adults aged 18 to 40 years. Methods Subjects were enrolled in …
View article: Gradient twinned 304 stainless steels for high strength and high ductility
Gradient twinned 304 stainless steels for high strength and high ductility Open