Aizhen Zhang
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View article: Kitlg dysfunction is associated with hearing and pigmentation abnormalities
Kitlg dysfunction is associated with hearing and pigmentation abnormalities Open
View article: Mitochondria Transfer in Mesenchymal Stem Cells: Unraveling the Mechanism and Therapeutic Potential
Mitochondria Transfer in Mesenchymal Stem Cells: Unraveling the Mechanism and Therapeutic Potential Open
Mesenchymal stem cells (MSCs) hold transformative potential in translational medicine due to their versatile differentiation abilities and regenerative properties. Notably, MSCs can transfer mitochondria to unrelated cells through intercel…
View article: Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model
Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model Open
Usher syndrome type 1C (USH1C) is a genetic disorder caused by mutations in the USH1C gene, which encodes harmonin, a key component of the mechanoelectrical transduction complex in auditory and vestibular hair cells. USH1C leads to deafnes…
View article: Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice
Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice Open
Cisplatin (CP), a chemotherapy drug commonly used in cancers treatment, causes serious reproductive toxicity. With younger cancer patients and increasing survival rates, it is important to preserve their reproductive capacity. NME8 is high…
View article: Causal effect of the age at first birth with depression: a mendelian randomization study
Causal effect of the age at first birth with depression: a mendelian randomization study Open
Background This study aimed to explore the causal relationship between age at first birth (AFB) and depression. Methods Using the univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) methods to examin…
View article: A novel mouse model carrying a gene trap insertion into the <i>Hmgxb4</i> gene locus to examine <i>Hmgxb4</i> expression in vivo
A novel mouse model carrying a gene trap insertion into the <i>Hmgxb4</i> gene locus to examine <i>Hmgxb4</i> expression in vivo Open
HMG (high mobility group) proteins are a diverse family of nonhistone chromosomal proteins that interact with DNA and a wide range of transcriptional regulators to regulate the structural architecture of DNA. HMGXB4 (also known as HMG2L1) …
View article: Pax2-cre-mediated deletion of Lgl1 causes abnormal development of the midbrain
Pax2-cre-mediated deletion of Lgl1 causes abnormal development of the midbrain Open
Lgl1 protein plays a critical role in neurodevelopment, including hippocampus, olfactory bulb, and Purkinje cell. However, the specific mechanism of LGL1 function in the midbrain remains elusive. In this study, we generated Lgl1 conditiona…
View article: Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice
Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice Open
Glutathione synthetase (GSS) catalyzes the final step in the synthesis of glutathione (GSH), a well-established antioxidant. Research on the specific roles of the Gss gene during spermatogenesis remains limited due to the intricate structu…
View article: Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels
Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels Open
The peroxisome is a ubiquitous organelle in rodent cells and plays important roles in a variety of cell types and tissues. It is previously indicated that peroxisomes are associated with auditory function, and patients with peroxisome biog…
View article: RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling
RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling Open
View article: Correction: High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates
Correction: High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates Open
View article: A Novel Mouse Model Carrying a Gene Trap Insertion into the Hmgxb4 Gene Locus to Examine Hmgxb4 Expression in Vivo
A Novel Mouse Model Carrying a Gene Trap Insertion into the Hmgxb4 Gene Locus to Examine Hmgxb4 Expression in Vivo Open
View article: Peer Review #1 of "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice (v0.1)"
Peer Review #1 of "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice (v0.1)" Open
Spermatogenesis and sperm maturation are complex and highly ordered biological processes.Any failure or disorder in these processes can cause defects in sperm morphology, motility, and fertilization ability.Cathepsin B (CTSB) is involved i…
View article: Peer Review #1 of "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice (v0.2)"
Peer Review #1 of "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice (v0.2)" Open
Spermatogenesis and sperm maturation are complex and highly ordered biological processes.Any failure or disorder in these processes can cause defects in sperm morphology, motility, and fertilization ability.Cathepsin B (CTSB) is involved i…
View article: Peer Review #2 of "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice (v0.1)"
Peer Review #2 of "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice (v0.1)" Open
Spermatogenesis and sperm maturation are complex and highly ordered biological processes.Any failure or disorder in these processes can cause defects in sperm morphology, motility, and fertilization ability.Cathepsin B (CTSB) is involved i…
View article: Peer Review #2 of "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice (v0.2)"
Peer Review #2 of "Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice (v0.2)" Open
Spermatogenesis and sperm maturation are complex and highly ordered biological processes.Any failure or disorder in these processes can cause defects in sperm morphology, motility, and fertilization ability.Cathepsin B (CTSB) is involved i…
View article: Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice
Cathepsin B plays a role in spermatogenesis and sperm maturation through regulating autophagy and apoptosis in mice Open
Spermatogenesis and sperm maturation are complex and highly ordered biological processes. Any failure or disorder in these processes can cause defects in sperm morphology, motility, and fertilization ability. Cathepsin B (CTSB) is involved…
View article: Pre‐meiotic deletion of <scp>PEX5</scp> causes spermatogenesis failure and infertility in mice
Pre‐meiotic deletion of <span>PEX5</span> causes spermatogenesis failure and infertility in mice Open
Peroxisomes are involved in the regulation of various pathological processes. Peroxisomal biogenesis factor 5 (PEX5), which plays an essential role in peroxisomal biogenesis, is critical for reactive oxygen species (ROS) accumulation. Howe…
View article: Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study
Effects of Moxa Cone Moxibustion Therapy on Cognitive Function and Brain Metabolic Changes in MCI Patients: A Pilot 1H-MRS Study Open
Objective To explore the effect of moxa cone moxibustion on N -acetyl aspartate/total creatinine (NAA/tCr) and choline/total creatinine (Cho/tCr) in the bilateral hippocampus (HIP) and bilateral posterior cingulate gyrus (PCG) in patients …
View article: Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss
Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss Open
Significance The mechanistic target of rapamycin (mTOR) plays a central role in growth, metabolism, and aging. It is assembled into two multiprotein complexes, namely, mTORC1 and mTORC2. We previously demonstrated the efficacy of sirolimus…
View article: SMPX Deficiency Causes Stereocilia Degeneration and Progressive Hearing Loss in CBA/CaJ Mice
SMPX Deficiency Causes Stereocilia Degeneration and Progressive Hearing Loss in CBA/CaJ Mice Open
The small muscle protein, x-linked ( SMPX ) encodes a small protein containing 88 amino acids. Malfunction of this protein can cause a sex-linked non-syndromic hearing loss, named X-linked deafness 4 (DFNX4). Herein, we reported a point mu…
View article: High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates
High levels of unbound bilirubin are associated with acute bilirubin encephalopathy in post-exchange transfusion neonates Open
View article: Hearing Loss in Id1−/−; Id3+/− and Id1+/−; Id3−/− Mice Is Associated With a High Incidence of Middle Ear Infection (Otitis Media)
Hearing Loss in Id1−/−; Id3+/− and Id1+/−; Id3−/− Mice Is Associated With a High Incidence of Middle Ear Infection (Otitis Media) Open
Inhibitors of differentiation/DNA binding (Id) proteins are crucial for inner ear development, but whether Id mutations affect middle ear function remains unknown. In this study, we obtained Id1 −/− ; Id3 +/− mice and Id1 +/− ; Id3 −/− mic…
View article: Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function
Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function Open
Piccolo is a presynaptic protein with high conservation among different species, and the expression of Piccolo is extensive in vertebrates. Recently, a small fragment of Piccolo (Piccolino), arising due to the incomplete splicing of intron…
View article: Relationship Between Unbound Bilirubin Levels and Acute Bilirubin Encephalopathy in Exchange Transfusion Neonates
Relationship Between Unbound Bilirubin Levels and Acute Bilirubin Encephalopathy in Exchange Transfusion Neonates Open
BACKGROUND : Evidence regarding the relationship between unbound bilirubin levels and acute bilirubin encephalopathy was limited. Therefore, this study set out to investigate whether the unbound bilirubin level was independently related to…
View article: [A multicenter survey of antibiotic use in very and extremely low birth weight infants in Hunan Province].
[A multicenter survey of antibiotic use in very and extremely low birth weight infants in Hunan Province]. Open
Antibiotics used for VLBW/ELBW infants in NICUs of Hunan Province are obviously prolonged in many NICUs. The proportion of routine use of third-generation of cephalosporins and carbapenems antibiotics is high among the NICUs.
View article: Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and (S)-Butin
Simultaneous Study of Anti-Ferroptosis and Antioxidant Mechanisms of Butein and (S)-Butin Open
To elucidate the mechanism of anti-ferroptosis and examine structural optimization in natural phenolics, cellular and chemical assays were performed with 2′-hydroxy chalcone butein and dihydroflavone (S)-butin. C11-BODIPY staining and flow…
View article: Role of CCR7 on dendritic cell‑mediated immune tolerance in the airways of allergy‑induced asthmatic rats
Role of CCR7 on dendritic cell‑mediated immune tolerance in the airways of allergy‑induced asthmatic rats Open
Dendritic cells (DCs) have an important role in initiating and maintaining the immune inflammatory response in allergic asthma, and CC chemokine receptor 7 (CCR7) is directly involved in the pathogenesis of DC‑ and T cell‑mediated allergic…
View article: The cognitive aging effect of route knowledge acquisition
The cognitive aging effect of route knowledge acquisition Open
View article: Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure
Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure Open
Background: Defects in protein homeostasis are sufficient to provoke cardiac remodeling and dysfunction. Although posttranslational modifications by ubiquitin and ubiquitin-like proteins are emerging as an important regulatory mechanism of…