A. Jennifer Morton
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View article: Learning and cognitive flexibility in two-choice visual discrimination tasks are similar in juvenile and adult sheep
Learning and cognitive flexibility in two-choice visual discrimination tasks are similar in juvenile and adult sheep Open
View article: Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease
Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease Open
Sleep and circadian disruption affects most individuals with Huntington’s disease (HD) at some stage in their lives. Sleep and circadian dysregulation are also present in many mouse and the sheep models of HD. Here I review evidence for sl…
View article: The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference
The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference Open
View article: Abnormally abrupt transitions from sleep-to-wake in Huntington’s disease sheep (Ovis aries) are revealed by automated analysis of sleep/wake transition dynamics
Abnormally abrupt transitions from sleep-to-wake in Huntington’s disease sheep (Ovis aries) are revealed by automated analysis of sleep/wake transition dynamics Open
Sleep disturbance is a common and disruptive symptom of neurodegenerative diseases such as Alzheimer’s and Huntington’s disease (HD). In HD patients, sleep fragmentation appears at an early stage of disease, although features of the earlie…
View article: Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease
Abnormal patterns of sleep and EEG power distribution during non-rapid eye movement sleep in the sheep model of Huntington's disease Open
View article: Approaches to Sequence the <i>HTT</i> CAG Repeat Expansion and Quantify Repeat Length Variation
Approaches to Sequence the <i>HTT</i> CAG Repeat Expansion and Quantify Repeat Length Variation Open
Background: Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of the HTT CAG repeat. Affected individuals inherit ≥36 repeats and longer alleles cause earlier onset, greater disease sever…
View article: Longitudinal Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging in Sheep (<i>Ovis aries</i>) With Quinolinic Acid Lesions of the Striatum: Time-Dependent Recovery of <i>N-</i>Acetylaspartate and Fractional Anisotropy
Longitudinal Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging in Sheep (<i>Ovis aries</i>) With Quinolinic Acid Lesions of the Striatum: Time-Dependent Recovery of <i>N-</i>Acetylaspartate and Fractional Anisotropy Open
We created an excitotoxic striatal lesion model of Huntington disease (HD) in sheep, using the N-methyl-d-aspartate receptor agonist, quinolinic acid (QA). Sixteen sheep received a bolus infusion of QA (75 µL, 180 mM) or saline, first into…
View article: Wake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6/2 Mouse Model of Huntington's Disease
Wake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6/2 Mouse Model of Huntington's Disease Open
View article: Expression and Localization of<i>Kcne2</i>in the Vertebrate Retina
Expression and Localization of<i>Kcne2</i>in the Vertebrate Retina Open
The data we present here suggest an important and specific role for Kcne2 in the highly specialized photoreceptor-bipolar cell synapse.
View article: Characterizing Sleep Spindles in Sheep
Characterizing Sleep Spindles in Sheep Open
Sleep spindles are distinctive transient patterns of brain activity that typically occur during non-rapid eye movement (NREM) sleep in humans and other mammals. Thought to be important for the consolidation of learning, they may also be us…
View article: Characterizing Sleep Spindles in Sheep.
Characterizing Sleep Spindles in Sheep. Open
Sleep spindles are distinctive transient patterns of brain activity that typically occur during non-rapid eye movement (NREM) sleep in humans and other mammals. Thought to be important for the consolidation of learning, they may also be us…
View article: Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits
Recommendations for measuring whisker movements and locomotion in mice with sensory, motor and cognitive deficits Open
View article: Increased plasma melatonin in presymptomatic Huntington disease sheep (<i>Ovis aries</i>): Compensatory neuroprotection in a neurodegenerative disease?
Increased plasma melatonin in presymptomatic Huntington disease sheep (<i>Ovis aries</i>): Compensatory neuroprotection in a neurodegenerative disease? Open
Melatonin is a pleiotrophic hormone, synthesised primarily by the pineal gland under the control of the suprachiasmatic nuclei (SCN). It not only provides a hormonal signal of darkness but also has neuroprotective properties. Huntington's …
View article: Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light
Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light Open
The circadian clock located in the suprachiasmatic nucleus (SCN) in mammals entrains to ambient light via the retinal photoreceptors. This allows behavioral rhythms to change in synchrony with seasonal and daily changes in light period. Ci…
View article: Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light.
Abnormal Photic Entrainment to Phase-Delaying Stimuli in the R6/2 Mouse Model of Huntington's Disease, despite Retinal Responsiveness to Light. Open
The circadian clock located in the suprachiasmatic nucleus (SCN) in mammals entrains to ambient light via the retinal photoreceptors. This allows behavioral rhythms to change in synchrony with seasonal and daily changes in light period. Ci…
View article: Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s disease
Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s disease Open
Antagonist pleiotropy, where a gene exerts a beneficial effect at early stages and a deleterious effect later on in an animal’s life, may explain the evolutionary persistence of devastating genetic diseases such as Huntington’s disease (HD…
View article: Neurological Examination of Sheep (Ovis aries) with Unilateral and Bilateral Quinolinic Acid Lesions of the Striatum Assessed by Magnetic Resonance Imaging
Neurological Examination of Sheep (Ovis aries) with Unilateral and Bilateral Quinolinic Acid Lesions of the Striatum Assessed by Magnetic Resonance Imaging Open
Acute toxic models of Huntington’s disease (HD) and Parkinson’s disease (PD) have been used extensively to study neuropathology and behaviour in rodents and non-human primates, but not large animals. We have created an acute quinolinic aci…
View article: mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease
mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease Open
View article: XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent
XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent Open
We have reported that the radical scavenger XJB-5-131 attenuates or reverses progression of the disease phenotype in the HdhQ(150/150) mouse, a slow onset model of HD. Here, we tested whether XJB-5-131 has beneficial effects in R6/2 mice, …
View article: Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease
Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease Open
View article: Early Neurodegeneration in R6/2 Mice Carrying the Huntington’s Disease Mutation with a Super-Expanded CAG Repeat, Despite Normal Lifespan
Early Neurodegeneration in R6/2 Mice Carrying the Huntington’s Disease Mutation with a Super-Expanded CAG Repeat, Despite Normal Lifespan Open
The threshold of CAG repeat expansion in the HTT gene that causes HD is 36 CAG repeats, although ‘superlong’ expansions are found in individual neurons in post mortem brains. Previously, we showed that, compared to mice with 440) CAG repea…
View article: Chronic paroxetine treatment prevents disruption of methamphetamine-sensitive circadian oscillator in a transgenic mouse model of Huntington's disease
Chronic paroxetine treatment prevents disruption of methamphetamine-sensitive circadian oscillator in a transgenic mouse model of Huntington's disease Open
View article: Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease
Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease Open
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a genetic expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse models have shown that artificial miRNAs can reduce mutant HTT, but evi…
View article: Sheep recognize familiar and unfamiliar human faces from two-dimensional images
Sheep recognize familiar and unfamiliar human faces from two-dimensional images Open
One of the most important human social skills is the ability to recognize faces. Humans recognize familiar faces easily, and can learn to identify unfamiliar faces from repeatedly presented images. Sheep are social animals that can recogni…
View article: Chronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington's Disease Mice
Chronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington's Disease Mice Open
View article: Single-cell RNA-seq of mouse dopaminergic neurons informs candidate gene selection for sporadic Parkinson’s disease
Single-cell RNA-seq of mouse dopaminergic neurons informs candidate gene selection for sporadic Parkinson’s disease Open
Genetic variation modulating risk of sporadic Parkinson’s disease (PD) has been primarily explored through genome wide association studies (GWAS). However, like many other common genetic diseases, the impacted genes remain largely unknown.…
View article: Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington’s disease
Characterisation of progressive motor deficits in whisker movements in R6/2, Q175 and Hdh knock-in mouse models of Huntington’s disease Open
View article: Potential molecular consequences of transgene integration: The R6/2 mouse example
Potential molecular consequences of transgene integration: The R6/2 mouse example Open
View article: Supplementary material from "Sheep recognize familiar and unfamiliar human faces from two-dimensional images"
Supplementary material from "Sheep recognize familiar and unfamiliar human faces from two-dimensional images" Open
One of the most important human social skills is the ability to recognize faces. Humans recognize familiar faces easily, and can learn to identify unfamiliar faces from repeatedly presented images. Sheep are social animals that can recogni…
View article: Techniques for chronic monitoring of brain activity in freely moving sheep using wireless EEG recording
Techniques for chronic monitoring of brain activity in freely moving sheep using wireless EEG recording Open