Ajaikumar B. Kunnumakkara
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View article: Bioresponsive engineered nanoparticles for immunomodulation
Bioresponsive engineered nanoparticles for immunomodulation Open
Nanomaterials possess significant immunomodulatory capabilities, enhancing both disease prevention and therapeutic efficacy in vivo, yet their clinical translation is hindered by complex fabrication methods and high production costs. Futur…
View article: Transforming Aquatic Waste into Healing Agent: Sustainable Extraction, Characterization and Bioactivity of Chitosan from Gibelion catla Scales
Transforming Aquatic Waste into Healing Agent: Sustainable Extraction, Characterization and Bioactivity of Chitosan from Gibelion catla Scales Open
Chitosan possesses innumerable implementations in the field of biomedical, pharmaceutical and industry. Chitin is an amino polysaccharide polymer occurring in the protective exoskeleton of fish, crustaceans, insects along with fungi, from …
View article: Mortalin Represents a Promising Therapeutic Target for Oral Cancers: Clinical Relevance and Experimental Evidence for the Activation of Akt/mTOR Signaling
Mortalin Represents a Promising Therapeutic Target for Oral Cancers: Clinical Relevance and Experimental Evidence for the Activation of Akt/mTOR Signaling Open
Background: Oral cancer remains a significant global health concern due to its high incidence and mortality, as highlighted by GLOBOCAN 2022, and is characterized by poor survival rates despite available therapies. Therefore, there is an i…
View article: Unlocking therapeutic potential: Exploring nuclear receptors in brain cancer treatment
Unlocking therapeutic potential: Exploring nuclear receptors in brain cancer treatment Open
Brain cancer remains among the most lethal malignancies worldwide, with approximately 321,476 new cases and 248,305 deaths reported globally in 2022. The treatment of malignant brain tumors presents substantial clinical challenges, primari…
View article: Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer
Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer Open
Background/Objectives: The integration of natural compounds in cancer research marked a crucial shift in the modern medical landscape, through a growing acknowledgment of their potential as efficient, less toxic, and cost-effective alterna…
View article: The solute carrier family 11 transporters: a bridge between iron homeostasis and tumor biology
The solute carrier family 11 transporters: a bridge between iron homeostasis and tumor biology Open
Iron is an essential trace element in the human body, and its imbalance is closely linked to the initiation and progression of various malignancies. The solute carrier family 11 (SLC11) transporters, comprising SLC11A1 and SLC11A2, play pi…
View article: Characterization of luciferase from an Indian firefly <i>Abscondita</i> sp. (Coleoptera: Lampiridae)
Characterization of luciferase from an Indian firefly <i>Abscondita</i> sp. (Coleoptera: Lampiridae) Open
Among the luminescent animals, fireflies have been extensively investigated throughout the world. Enzymatic characterization using recombinant proteins has been achieved after the first cloning of the Photinus pyralis luciferase gene. Fire…
View article: Anti- Cancer Potential of Diosgenin, a Steroidal Saponin, against Human Oral Cancer Cells
Anti- Cancer Potential of Diosgenin, a Steroidal Saponin, against Human Oral Cancer Cells Open
These findings support the therapeutic potential of diosgenin, thereby opening a new avenue for oral cancer therapy. Nonetheless, the data needs to be further validated in in vivo and clinical settings.
View article: Gut microbiota and their influence in brain cancer milieu
Gut microbiota and their influence in brain cancer milieu Open
Microbial communities are not simply remnants of the past but dynamic entities that continuously evolve under the selective pressures of nature, reflecting the intricate and adaptive processes of evolution. The microbiota residing in the v…
View article: Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy
Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy Open
Capsaicin (CAPS), a bioactive alkaloid derived from chili peppers, has garnered significant interest for its potential role as a combinatorial and chemosensitizing agent in cancer therapy. Numerous preclinical studies have demonstrated tha…
View article: Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases
Chladni and Fractal Dynamics: Dual Mode Marker to Map Cancer Cell Nucleus Disintegration Phases Open
Conventional cancer drugs are small molecules that target specific pathways. We introduced PCMS, a 26 kDa supramolecule combining sensors (S), molecular motors (M), and switching molecules (C), integrated within a fourth-generation PAMAM s…
View article: Regulating the regulators: long non-coding RNAs as autophagic controllers in chronic disease management
Regulating the regulators: long non-coding RNAs as autophagic controllers in chronic disease management Open
View article: Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials
Targeting RTKs/nRTKs as promising therapeutic strategies for the treatment of triple-negative breast cancer: evidence from clinical trials Open
View article: Potassium tantalum niobate: Structural insights and biocompatibility for biomedical applications
Potassium tantalum niobate: Structural insights and biocompatibility for biomedical applications Open
This study explores the biomedical applications of electrically active potassium tantalum niobate (KTN) ceramics (KTa 1 − x Nb x O 3 ; where x = 0.0, 0.1, 0.3, 0.5, and 0.7), focusing on their dielectric and biological properties for bioel…
View article: Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases
Tackling exosome and nuclear receptor interaction: an emerging paradigm in the treatment of chronic diseases Open
View article: Nuclear receptors in ovarian cancer: changing paradigms in cancer therapeutics
Nuclear receptors in ovarian cancer: changing paradigms in cancer therapeutics Open
Ovarian cancer (OVC) is one of the most common causes of cancer-related deaths in women worldwide. Despite advancements in detection and therapy, the prognosis of OVC remains poor due to late diagnosis and the lack of effective therapeutic…
View article: The emerging role of human papillomavirus in lung cancer
The emerging role of human papillomavirus in lung cancer Open
Lung cancer stands as one of the most lethal diseases and is the foremost cause of cancer-related mortalities worldwide. The pathophysiology of lung cancer is multifaceted, and it includes multiple cell signaling pathways and other complex…
View article: Natural Prenylflavones from the Stem Bark of <i>Artocarpus altilis</i>: Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT-3 Signaling Pathway
Natural Prenylflavones from the Stem Bark of <i>Artocarpus altilis</i>: Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT-3 Signaling Pathway Open
Artonin E (AA2) and artobiloxanthone (AA3) were extracted and purified from the acetone extract of the stem bark of Artocarpus altilis (Parkinson) Fosberg. Preliminary investigations of both candidates revealed promising cytotoxic e…
View article: Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges
Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges Open
Cancer has become a burgeoning global healthcare concern marked by its exponential growth and significant economic ramifications. Though advancements in the treatment modalities have increased the overall survival and quality of life, ther…
View article: Targeted inhibition of colorectal cancer proliferation: The <scp>dual‐modulatory</scp> role of 2,<scp>4‐DTBP</scp> on <scp>anti‐apoptotic</scp> Bcl‐2 and Survivin proteins
Targeted inhibition of colorectal cancer proliferation: The <span>dual‐modulatory</span> role of 2,<span>4‐DTBP</span> on <span>anti‐apoptotic</span> Bcl‐2 and Survivin proteins Open
The anti‐apoptotic proteins, Bcl‐2 and Survivin, are consistently overexpressed in numerous human malignancies, notably in colorectal cancer. 2,4‐Di‐tert‐butylphenol (2,4‐DTBP) is a naturally occurring phenolic compound known for its diver…
View article: Review of: "[Case Study] Targeting the Warburg Effect with the Glucose Mutation Theory: A Case Study of a 35-Year-Old Female Treated for Stage II Triple-Positive Metastatic Breast Cancer Involving Lymph Nodes Using Glucosodiene Over a 20-Day Period."
Review of: "[Case Study] Targeting the Warburg Effect with the Glucose Mutation Theory: A Case Study of a 35-Year-Old Female Treated for Stage II Triple-Positive Metastatic Breast Cancer Involving Lymph Nodes Using Glucosodiene Over a 20-Day Period." Open
View article: Preface
Preface Open
View article: Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far?
Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far? Open
View article: Delineating the role of nuclear receptors in colorectal cancer, a focused review
Delineating the role of nuclear receptors in colorectal cancer, a focused review Open
View article: Exploring the nexus of nuclear receptors in hematological malignancies
Exploring the nexus of nuclear receptors in hematological malignancies Open
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and multiple myeloma. Their prognosis varies considerably, with a frequ…
View article: Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review
Harnessing Sulforaphane Potential as a Chemosensitizing Agent: A Comprehensive Review Open
Recent advances in oncological research have highlighted the potential of naturally derived compounds in cancer prevention and treatment. Notably, sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables including broccoli…
View article: Scirpusin B isolated from Passiflora edulis Var. flavicarpa attenuates carbohydrate digestive enzymes, pathogenic bacteria and oral squamous cell carcinoma
Scirpusin B isolated from Passiflora edulis Var. flavicarpa attenuates carbohydrate digestive enzymes, pathogenic bacteria and oral squamous cell carcinoma Open
View article: Sexual Dysfunction in Neurological Disorders with Special Emphasis on Parkinson’s Disease: Insights from Clinical Studies and Animal Models
Sexual Dysfunction in Neurological Disorders with Special Emphasis on Parkinson’s Disease: Insights from Clinical Studies and Animal Models Open
Epidemiological studies illustrate that sexual dysfunction (SD) is common among the majority of patients suffering from neurological disorders (NLDs). However, our understanding of the SD in NLDs is in its infancy. Our effort in this revie…
View article: Crosstalk between Non-Coding RNAs and Wnt/β-Catenin Signaling in Head and Neck Cancer: Identification of Novel Biomarkers and Therapeutic Agents
Crosstalk between Non-Coding RNAs and Wnt/β-Catenin Signaling in Head and Neck Cancer: Identification of Novel Biomarkers and Therapeutic Agents Open
Head and neck cancers (HNC) encompass a broad spectrum of neoplastic disorders characterized by significant morbidity and mortality. While contemporary therapeutic interventions offer promise, challenges persist due to tumor recurrence and…
View article: Calebin A targets the HIF-1α/NF-κB pathway to suppress colorectal cancer cell migration
Calebin A targets the HIF-1α/NF-κB pathway to suppress colorectal cancer cell migration Open
Background: Hypoxia-inducible factor-1α (HIF-1α) is one of the major tumor-associated transcription factors modulating numerous tumor properties such as tumor cell metabolism, survival, proliferation, angiogenesis, and metastasis. Calebin …