Ajay Abraham
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View article: IgM and IgG1 B cell receptors differentially affect B cell fates and dictate the pathogenesis of mature B cell lymphomas
IgM and IgG1 B cell receptors differentially affect B cell fates and dictate the pathogenesis of mature B cell lymphomas Open
Malignant B cells rely on B cell receptor (BCR) signals for their survival and growth. Besides the Immunoglobulin M (IgM) BCR, lymphoma cells can also express non–IgM (IgG) BCRs; however, the role of IgG BCRs in malignant B cell is not wel…
View article: 97P VREAL: Use of virtual reality for emotional wellbeing of sarcoma patients - Preliminary results
97P VREAL: Use of virtual reality for emotional wellbeing of sarcoma patients - Preliminary results Open
View article: WCN25-2895 THE DARK SIDE OF TACROLIMUS IN KIDNEY TRANSPLANT RECEPIENTS
WCN25-2895 THE DARK SIDE OF TACROLIMUS IN KIDNEY TRANSPLANT RECEPIENTS Open
View article: Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient germinal center B cell responses
Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient germinal center B cell responses Open
View article: WCN24-1127 A PROSPECTIVE STUDY ON MINERAL BONE DISEASE IN POST RENAL TRANSPLANT PATIENTS
WCN24-1127 A PROSPECTIVE STUDY ON MINERAL BONE DISEASE IN POST RENAL TRANSPLANT PATIENTS Open
The CKD epidemic is a worldwide public health problem, associated with premature death, increased morbidity. Renal transplantation is considered to be the best renal replacement therapy option for patients with advanced chronic kidney dise…
View article: Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient Germinal Center B cell responses
Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient Germinal Center B cell responses Open
Differentiating B cells in germinal centers (GC) require tightly coordinated transcriptional and epigenetic transitions to generate efficient humoral immune responses. The mammalian Brg1/Brm-associated factor (BAF) complexes are major regu…
View article: Toward a systems-level probing of tumor clonality
Toward a systems-level probing of tumor clonality Open
View article: Low c-Kit expression identifies primitive, therapy-resistant CML stem cells
Low c-Kit expression identifies primitive, therapy-resistant CML stem cells Open
Despite the efficacy of tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML), malignant long-term hematopoietic stem cells (LT-HSCs) persist as a source of relapse. However, LT-HSCs are heterogenous and the most primitive, d…
View article: Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection
Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection Open
Objectives This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVI…
View article: Hedgehog Signaling in Myeloid Malignancies
Hedgehog Signaling in Myeloid Malignancies Open
Myeloid malignancies arise from normal hematopoiesis and include several individual disorders with a wide range of clinical manifestations, treatment options, and clinical outcomes. The Hedgehog (HH) signaling pathway is aberrantly activat…
View article: PO-1420 iCARE: sarcoma patient radiotherapy experience during COVID-19
PO-1420 iCARE: sarcoma patient radiotherapy experience during COVID-19 Open
View article: Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling
Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling Open
View article: Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice Open
View article: Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions
Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions Open
View article: SIRT1 regulates metabolism and leukemogenic potential in CML stem cells
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells Open
Chronic myeloid leukemia (CML) results from hematopoietic stem cell transformation by the BCR-ABL kinase. Despite the success of BCR-ABL tyrosine kinase inhibitors (TKIs) in treating CML patients, leukemia stem cells (LSCs) resist eliminat…
View article: Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2
Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2 Open
Cytarabine (Ara-C) and Daunorubicin (Dnr) forms the backbone of acute myeloid leukemia (AML) therapy. Drug resistance and toxic side effects pose a major threat to treatment success and hence alternate less toxic therapies are warranted. N…
View article: Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia
Population pharmacokinetics of Daunorubicin in adult patients with acute myeloid leukemia Open
View article: RNA Expression of Genes Involved in Cytarabine Metabolism and Transport Predicts Cytarabine Response in Acute Myeloid Leukemia
RNA Expression of Genes Involved in Cytarabine Metabolism and Transport Predicts Cytarabine Response in Acute Myeloid Leukemia Open
This study highlights the importance of evaluating expression of candidate Ara-C metabolizing genes in predicting ex vivo drug response as well as treatment outcome. RI could be a predictor of ex vivo Ara-C response irrespective of cytogen…