Ajay Tambralli
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View article: Molecular stratification of antiphospholipid syndrome through integrative analysis of the whole‐blood RNA transcriptome
Molecular stratification of antiphospholipid syndrome through integrative analysis of the whole‐blood RNA transcriptome Open
Objective Antiphospholipid syndrome ( APS ) is a thrombo‐inflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular…
View article: Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome
Prothrombotic Activation of Platelet Pannexin 1 Channels in Antiphospholipid Syndrome Open
Background ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. Objective To evaluate the role of platel…
View article: Neutrophils take center stage in VEXAS syndrome pathogenesis
Neutrophils take center stage in VEXAS syndrome pathogenesis Open
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is an adult-onset inflammatory disorder caused by somatic UBA1 mutations in hematopoietic stem cells. UBA1 encodes a key enzyme that catalyzes protein ubiquitination…
View article: A disrupted adenosinergic axis facilitates platelet activation in APS: exploring a novel therapeutic target
A disrupted adenosinergic axis facilitates platelet activation in APS: exploring a novel therapeutic target Open
Platelet activation is a hallmark of antiphospholipid syndrome (APS). However, the mechanisms through which antiphospholipid antibodies activate platelets and the optimal way to inhibit this pathophysiology are still not fully understood. …
View article: Soluble CD13 is a potential mediator of neutrophil-induced thrombogenic inflammation in SARS-CoV-2 infection
Soluble CD13 is a potential mediator of neutrophil-induced thrombogenic inflammation in SARS-CoV-2 infection Open
The soluble variant of the ectopeptidase CD13 (sCD13), released from the cell surface by matrix metalloproteinase 14 (MMP14), is a potent pro-inflammatory mediator, displaying chemotactic, angiogenic, and arthritogenic properties through b…
View article: Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome
Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome Open
Neutrophil hyperactivity and neutrophil extracellular trap release (NETosis) appear to play important roles in the pathogenesis of the thromboinflammatory autoimmune disease known as antiphospholipid syndrome (APS). The understanding of ne…
View article: Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice
Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice Open
While neutrophil extracellular traps (NETs) have previously been linked to some diabetes-associated complications, such as dysfunctional wound healing, their potential role in diabetic vascular dysfunction has not been studied. Diabetic Ak…
View article: Predictors and Interrelationship of <scp>Patient‐Reported</scp> Outcomes in Antiphospholipid Syndrome: A <scp>Cross‐Sectional</scp> Study
Predictors and Interrelationship of <span>Patient‐Reported</span> Outcomes in Antiphospholipid Syndrome: A <span>Cross‐Sectional</span> Study Open
Objective This study assessed patient‐reported outcomes (PROs) in individuals with persistently positive antiphospholipid antibodies (aPL) to better understand how living with aPL may affect their quality of life. Methods Patients complete…
View article: Utilizing type I interferon expression in the identification of antiphospholipid syndrome subsets
Utilizing type I interferon expression in the identification of antiphospholipid syndrome subsets Open
To date, the scarce available data as well as methodological and technical heterogeneity among studies limit the comparability of the results, thus requiring further validation to translate these findings to routine clinical practice. Ther…