Explanipedia

MTHFR C677T rs1801133 and TP53 Pro72Arg rs1042522 gene variants in South African Indian and Caucasian psoriatic arthritis patients Open

Pragalathan Naidoo, Ajesh B. Maharaj, Terisha Ghazi, Anil A. Chuturgoon · 2025

Methylenetetrahydrofolate reductase (MTHFR) gene is involved in homocysteine and folic acid metabolism. Tumour suppressor protein TP53 gene maintains cellular and genetic integrity. To date, no studies associated the MTHFR C677T rs1801133 …

Global RA treatment recommendations: An update from the various international societies Open

Charles Cubberley, Ajesh B. Maharaj · 2024

Rheumatoid arthritis is a chronic inflammatory arthritis with many extra-articular manifestations and is associated with an increased risk of morbidity and mortality. This review attempts to provide an update on the treatment recommendatio…

Systemic Vasculitis Post-COVID-19: A Case Report Open

Shamsun Nahar, Masud Husain, Ajesh B. Maharaj, Mohit Lakkimsetti, Yashwanth Vemoori , et al. · 2024

Vasculitis is one of the complications of COVID. Coronavirus may trigger or exacerbate autoimmune diseases, such as systemic vasculitis. We present the case of an elderly individual with a medical history that includes recurrent urinary tr…

South African Rheumatism and Arthritis Association 2024 guidelines for the management of peripheral spondyloarthritis Open

R Benitha, Ajesh B. Maharaj, Kavita Makan, James E. Potts, A Lai , et al. · 2024

Peripheral spondyloarthritis (SpA) includes psoriatic arthritis (PsA), inflammatory bowel disease (IBD)-associated arthritis, reactive arthritis and undifferentiated peripheral SpA. These South African guidelines offer information on diagn…

South African Rheumatism and Arthritis Association 2024 guidelines for the management of axial spondyloarthritis Open

Bridget Hodkinson, Ajesh B. Maharaj, R Benitha, Kavita Makan, R Du Toit , et al. · 2024

Early diagnosis and prompt treatment initiation are essential in the management of axial spondyloarthritis (axSpA), also known as ankylosing spondylitis, remembering that underdiagnosis and overdiagnosis of axSpA are common. These South Af…

South African Rheumatism and Arthritis Association 2024 guidelines for the management of axial spondyloarthritis Open

Ajesh B. Maharaj, R Benitha, Kavita Makan, R Du Toit, D Haasbroek , et al. · 2024

Early diagnosis and prompt treatment initiation are essential in the management of axial spondyloarthritis (axSpA), also known as ankylosing spondylitis, remembering that underdiagnosis and overdiagnosis of axSpA are common. These South Af…

South African Rheumatism and Arthritis Association 2024 guidelines for the management of peripheral spondyloarthritis Open

R Benitha, Ajesh B. Maharaj, Kavita Makan, James E. Potts, A Lai , et al. · 2024

Peripheral spondyloarthritis (SpA) includes psoriatic arthritis (PsA), inflammatory bowel disease (IBD)-associated arthritis, reactive arthritis and undifferentiated peripheral SpA. These South African guidelines offer information on diagn…

Introduction to the South African Rheumatism and Arthritis Association 2024 guidelines Open

Bridget Hodkinson, Esther van Vuuren, Ajesh B. Maharaj, Farhanah Paruk, Kavita Makan · 2024

The guidelines in this series provide evidence-based practical guidance for the diagnosis, treatment and follow-up of persons with inflammatory joint diseases. The purpose of these guidelines is to aid in shared decision-making between pat…

Consensus on the definitions and descriptions of the domains of the OMERACT Core Outcome Set for shared decision making interventions in rheumatology trials Open

Simon Décary, Maarten de Wit, Florian Naye, Jennifer L. Barton, Liana Fraenkel , et al. · 2024

Consensus on the Definitions and Descriptions of the Domains of the Omeract Core Outcome Set for Shared Decision Making Interventions in Rheumatology Trials Open

Simon Décary, Maarten de Wit, Florian Naye, Jennifer L. Barton, Liana Fraenkel , et al. · 2023

Management of Psoriatic Arthritis in Patients With Comorbidities: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations Open

Cristiano Campanholo, Ajesh B. Maharaj, Nadia Corp, Stacie Bell, Luisa Costa , et al. · 2022

Objective The 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations provide an evidence-based guide for selecting therapy based on the individual's disease features. Beyond the disea…

Managing ANCA-associated vasculitis during the COVID-19 pandemic: results from an online survey Open

Chirag Rajkumar Kopp, GSRSNK Naidu, Durga Prasanna Misra, Prateek Deo, Roopesh Sai Jakulla , et al. · 2021

Endorsement of the OMERACT core domain set for shared decision making interventions in rheumatology trials: Results from a multi-stepped consensus-building approach Open

Karine Toupin‐April, Simon Décary, Maarten de Wit, Alexa Meara, Jennifer L. Barton , et al. · 2021

Points to consider in cardiovascular disease risk management among patients with rheumatoid arthritis living in South Africa, an unequal middle income country Open

Ahmed Solomon, Anne E Stanwix, Santos Castañeda, Javier Llorca, Carlos González‐Juanatey , et al. · 2020

International league of associations for rheumatology recommendations for the management of psoriatic arthritis in resource-poor settings Open

Musaab Elmamoun, Maria Aranzazu Eraso, Melanie Anderson, Ajesh B. Maharaj, Laura C. Coates , et al. · 2020

Background Psoriatic arthritis (PsA) is a challenging heterogeneous disease. The European League Against Rheumatism (EULAR) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) last published their respective recommendat…

OP0312 International league of associations for rheumatology (ILAR) treatment recommendations for psoriatic arthritis in resource-poor countries Open

Musaab Elmamoun, Maria Aranzazu Eraso, Ajesh B. Maharaj, Vinod Chandran, Laura C. Coates , et al. · 2018

MiR-146a G/C rs2910164 variation in South African Indian and Caucasian patients with psoriatic arthritis Open

Ajesh B. Maharaj, Pragalathan Naidoo, Terisha Ghazi, Naeem Sheik Abdul, Shanel Dhani , et al. · 2018

Characterization of psoriatic arthritis in South Africa studies on a single centre cohort Open

Ajesh B. Maharaj · 2018

This thesis describes the clinical, radiological and genetic associations of psoriatic arthritis in a single centre cohort in South Africa. The introduction discusses the various aspects of psoriasis and psoriatic arthritis(PsA). I also di…

Sarcoid Tattoo Granuloma and Ocular Sarcoidosis: The Great Masquerader Open

Ajesh B. Maharaj, Jackie Cook, SA Lalchan, M Suite, S Barrow · 2016

Sarcoidosis is a multisystem disease with both sight and life-threatening sequelae.It can be a diagnostic challenge as there is no definitive test.The IWOS has recommended guidelines to improve diagnostic certainty to improve early detecti…

Psoriatic arthritis: An assessment of clinical, biochemical and radiological features in a single-centre South African cohort Open

Ajesh B. Maharaj, Michelle Rajkaran, Jayandran Govender, Kasthurba Maharaj, Niek de Vries , et al. · 2016

The complete absence of black South Africans with PsA is interesting. We anticipate that our findings will prompt genetic studies to isolate both protective and susceptibility genes for further elucidating PsA.

McArdle’s disease presenting with acute renal failure Open

Ajesh B. Maharaj, Vinod Patel · 2016

We report on an interesting patient who presented with acute renal failure from rhabdomyolysis and was found to have McArdle's disease on further investigation.

2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative Open

Christian Dejaco, Yogesh Preet Singh, Pablo Perel, Andrew Hutchings, Dario Camellino , et al. · 2015

2015 Recommendations for the Management of Polymyalgia Rheumatica: A European League Against Rheumatism/American College of Rheumatology Collaborative Initiative Open

Christian Dejaco, Yogesh Preet Singh, Pablo Perel, Andrew Hutchings, Dario Camellino , et al. · 2015

Therapy for polymyalgia rheumatica (PMR) varies widely in clinical practice as international recommendations for PMR treatment are not currently available. In this paper, we report the 2015 European League Against Rheumatism (EULAR)/Americ…

Drs. Maharaj and Chandran reply Open

Ajesh B. Maharaj, Vinod Chandran · 2015

To the Editor: We thank Dr. Rothschild1 for raising an important issue. We do agree with you that synostosis does occur in spondyloarthritis, as … Address correspondence to Dr A.B. Maharaj, Academic Medical Center, Immunology and Rheumatol…

Summary of Sensitivity and Specificity for Psoriatic Arthritis in a South African Cohort according to Classification Criteria Open

Ajesh B. Maharaj, Jayandran Govender, Kasthurba Maharaj, Michelle Rajkaran, Paul P. Tak · 2015

Objective. To evaluate the sensitivity and specificity of the classification criteria for psoriatic arthritis (PsA) in a South African cohort. Methods. Data from consecutive patients with PsA and other chronic inflammatory arthritides were…

Pancytopenia in a Patient with Psoriatic Arthritis Treated with Methotrexate and Concomitant Lithium Open

Ajesh B. Maharaj, Vinod Chandran · 2015

To the Editor: We report a case of pancytopenia in a patient with psoriatic arthritis (PsA) treated with methotrexate (MTX) and concomitant lithium. Our index patient was a 55-year-old white female who had PsA since age 28. She had arthrit…

Spondyloarthritis in African Blacks Open

Ajesh B. Maharaj, Paul P. Tak · 2015

To the Editor: Psoriatic arthritis (PsA) appears extremely rarely in African black populations1,2. To the best of our knowledge, no population-based data are currently available on the prevalence and incidence of PsA in the African black p…

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