Ajit Kumar Thakur
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View article: Shock-Related Thyroid Changes: A Rare Presentation in a Young Patient With Hemorrhagic Shock Secondary to a Road Traffic Accident
Shock-Related Thyroid Changes: A Rare Presentation in a Young Patient With Hemorrhagic Shock Secondary to a Road Traffic Accident Open
Shock-related thyroid changes are a rare radiological finding, considered part of the hypovolemic shock complex. It is characterized by thyroidal and perithyroidal edema without direct thyroid injury, typically seen in severe trauma. Very …
View article: Development And Characterization of Microspongel Containing Herbal Drug Ginkgo biloba’s extract.
Development And Characterization of Microspongel Containing Herbal Drug Ginkgo biloba’s extract. Open
In this study, microsponges containing Ginkgo biloba extract were prepared using quasi-emulsion solvent diffusion method and evaluated for various parameters including particle size, encapsulation efficiency, surface morphology, and in vit…
View article: Anti-Neuropathic Efficacy of Homoeopathic Dilutions of <i>Toxicodendron pubescens</i>: A Preclinical Study
Anti-Neuropathic Efficacy of Homoeopathic Dilutions of <i>Toxicodendron pubescens</i>: A Preclinical Study Open
Background: Toxicodendron pubescens Mill., the botanical name of Rhus toxicodendron (Rhus tox), also known as ‘poison ivy’, belongs to the family of Anacardiaceae and is widely used in the traditional system of Homoeopathy medicine. Its cr…
View article: Comparison of Visual Acuity and Stereoacuity Outcomes with Vision Therapy between within- and Beyond-Critical-Period in Amblyopic Patients: A Pilot Study
Comparison of Visual Acuity and Stereoacuity Outcomes with Vision Therapy between within- and Beyond-Critical-Period in Amblyopic Patients: A Pilot Study Open
Purpose: To compare visual acuity (VA) and near stereoacuity before and after active vision therapy (AVT) in amblyopic patients, specifically those with anisometropic, strabismic or combined mechanism amblyopia, both in within-critical-per…
View article: Attempts to Develop Vaccines Against Alzheimer’s Disease: A Systematic Review of Ongoing and Completed Vaccination Trials in Humans
Attempts to Develop Vaccines Against Alzheimer’s Disease: A Systematic Review of Ongoing and Completed Vaccination Trials in Humans Open
In this systematic review, we evaluate the safety, tolerability, and immunogenicity of vaccination efforts against Alzheimer's disease (AD) in human subjects from both ongoing and completed vaccination trials. Databases like PubMed, Embase…
View article: Drugs acting on the renin–angiotensin–aldosterone system (RAAS) and deaths of COVID-19 patients: a systematic review and meta-analysis of observational studies
Drugs acting on the renin–angiotensin–aldosterone system (RAAS) and deaths of COVID-19 patients: a systematic review and meta-analysis of observational studies Open
Background Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs) are two of the most commonly used antihypertensive drugs acting on the renin–angiotensin–aldosterone system (RAAS). Previous research has s…
View article: Mitochondrial dysfunctions and neurodegenerative diseases: a mini-review
Mitochondrial dysfunctions and neurodegenerative diseases: a mini-review Open
Mitochondrial dysfunction is estimated to be the primary reason involved in different types of neurodegenerative disorders as mitochondria is suggested to be important in the production of reactive oxygen species. Recently, several evidenc…
View article: Neurological manifestations and comorbidity associated with COVID-19: an overview
Neurological manifestations and comorbidity associated with COVID-19: an overview Open
View article: Outcome of relaxing retinectomies in management of failed rhegmatogenous retinal detachment surgery cases with proliferative vitreoretinopathy changes
Outcome of relaxing retinectomies in management of failed rhegmatogenous retinal detachment surgery cases with proliferative vitreoretinopathy changes Open
View article: Blood lead levels among the occupationally exposed workers and its effect on calcium and vitamin D metabolism: A case-control study
Blood lead levels among the occupationally exposed workers and its effect on calcium and vitamin D metabolism: A case-control study Open
Our study results demonstrated that high BLL significantly alter vitamin D and calcium metabolism. The data extrapolated from our study emphasizes the necessity of surveillance in exposed workers. As the associated deleterious effects of P…
View article: Ocular manifestations in tuberculosis cases with HIV in Nepal
Ocular manifestations in tuberculosis cases with HIV in Nepal Open
Introduction: TB has seen resurgence associated with HIV. Tuberculosis can affect any ocular tissue. The association of HIV with TB is supposed to increase the incidence and plethora of ocular manifestations in tuberculosis.
Objectives: T…
View article: Evaluation of Alpha Glucosidase Inhibitor (Miglitol) for its Efficacy in Constipation Associated with Diabetes
Evaluation of Alpha Glucosidase Inhibitor (Miglitol) for its Efficacy in Constipation Associated with Diabetes Open
Objectives: Recently, miglitol emerged as effective α-glucosidase inhibitor for the treatment of diabetic mellitus with specific advantages over currently available class of antidiabetic drugs. The aim of the present study was to evaluate …
View article: Comorbid brain disorders associated with diabetes: therapeutic potentials of prebiotics, probiotics and herbal drugs
Comorbid brain disorders associated with diabetes: therapeutic potentials of prebiotics, probiotics and herbal drugs Open
Prevalence of diabetes and comorbid brain disorders is increasing worldwide particularly in low- and middle-income countries. Diabetes and its complications impose substantial economic costs on the developing countries. Several comorbid co…
View article: Clinical Accuracy of the Nidek ARK-1 Autorefractor
Clinical Accuracy of the Nidek ARK-1 Autorefractor Open
SIGNIFICANCE Autorefractors are commonly used by eye care practitioners worldwide as a starting point for clinical prescribing and by researchers as an instrument to study development of refractive errors and accommodation. This study demo…
View article: Modulation of the immune response and infection pattern to Leishmania donovani in visceral leishmaniasis due to arsenic exposure: An in vitro study
Modulation of the immune response and infection pattern to Leishmania donovani in visceral leishmaniasis due to arsenic exposure: An in vitro study Open
The arsenic contamination of ground water in visceral leishmaniasis (VL) endemic areas in Bihar, India leads to human exposure through drinking water. Possibly, the consumed arsenic (As) accumulates in the tissues of VL patients, who subse…
View article: Therapeutic Potential and Recent Development of Psychobiotics for the Management of Brain Disorders
Therapeutic Potential and Recent Development of Psychobiotics for the Management of Brain Disorders Open
Translational studies indicate that probiotics may have an impact on depression, stress responses, anxiety, behavior and cognitive functions.Psychobiotics are the type of probiotic substances having potential mental health benefits when in…
View article: Ocular Manifestations among Systemic Tuberculosis Cases: A Hospital Based Study from Nepal
Ocular Manifestations among Systemic Tuberculosis Cases: A Hospital Based Study from Nepal Open
Aim: To study the frequency of various ocular manifestations in diagnosed cases of active pulmonary and extra pulmonary tuberculosis in two different major hospitals in Nepal. Method: A hospital based, cross sectional descriptive study was…
View article: Biochemical evaluation of vitamin D levels in pre diabetes, type 2 diabetes mellitus and its correlation with glycated hemoglobin
Biochemical evaluation of vitamin D levels in pre diabetes, type 2 diabetes mellitus and its correlation with glycated hemoglobin Open
Introduction: Globally, 1 billion people are suffering with deficiency or insufficiency of vitamin D. Vitamin D deficiency is also associated with metabolic disorders. This study evaluates Vitamin D levels in prediabetes, T2DM patients and…
View article: Pharmacotherapeutics of miglitol: an α-glucosidase inhibitor
Pharmacotherapeutics of miglitol: an α-glucosidase inhibitor Open
Diabetes Mellitus (DM) is a morbid disease globally, with growing prevalence as time passes.Diabetes produces macrovascular and microvascular complications.The key cause of these complications is poorly precise postprandial hyperglycemia.V…
View article: Pathophysiology and management of alzheimer’s disease: an overview
Pathophysiology and management of alzheimer’s disease: an overview Open
Alzheimer's disease (AD) is the sixth-leading reason of fatality and is 70% present in all cases of dementia.The global burden of AD is expected to accelerate from 26.6 million cases in 2006 to 106.8 million by 2050.The total assumed world…
View article: A Status Report on Autonomic Nervous System: the Indian Research Scenario during the Last Five Years
A Status Report on Autonomic Nervous System: the Indian Research Scenario during the Last Five Years Open
Autonomic nervous system, as complex, multi-faceted neural networks has now emerged as an important system involved in various neuropsychiatric and neurodegenerative including memory disorders in addition to cardiovascular diseases.Earlier…
View article: Cedrus deodara
Cedrus deodara Open
Background & objectives: The existing antileishmanial drugs for complete cure of visceral leishmaniasis (kala-azar) are limited. The available drugs are either toxic or less effective leading to disease relapse or conversion to post-kala-a…
View article: Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review
Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review Open
Glycyrrhiza glabra Linn.(Family: Fabaceae) is a traditional medicinal plant used in various ancient medicine systems and documented across the globe for its ethanopharmacological value to cure varieties of ailments.Glycyrrhizin is the majo…