Akash Mathavan
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View article: A comprehensive review and case series of adjuvant and neoadjuvant therapies in acral melanoma with emerging insights from CT DNA testing
A comprehensive review and case series of adjuvant and neoadjuvant therapies in acral melanoma with emerging insights from CT DNA testing Open
Introduction Acral melanoma is a rare but aggressive type of skin cancer that appears on the hands, feet, and under the nails. Unlike other melanomas, it is not linked to sun exposure and has unique genetic features that may require differ…
View article: Incidence of Immune Checkpoint Inhibitor–Associated Renal Tubular Acidosis
Incidence of Immune Checkpoint Inhibitor–Associated Renal Tubular Acidosis Open
View article: Case report: Novel homozygous ACVRL1 missense variant in a family with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension: findings suggest a hypomorphic allele
Case report: Novel homozygous ACVRL1 missense variant in a family with hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension: findings suggest a hypomorphic allele Open
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant vascular disorder caused by pathogenic variants in genes within the transforming growth factor beta (TGF-β) signaling pathway, such as ACVRL1 , leading to haploinsufficie…
View article: Abdominal pain in a patient with epistaxis, telangiectasias, and arteriovenous malformations
Abdominal pain in a patient with epistaxis, telangiectasias, and arteriovenous malformations Open
View article: Vaccines: a promising therapy for myelodysplastic syndrome
Vaccines: a promising therapy for myelodysplastic syndrome Open
Myelodysplastic neoplasms (MDS) define clonal hematopoietic malignancies characterized by heterogeneous mutational and clinical spectra typically seen in the elderly. Curative treatment entails allogeneic hematopoietic stem cell transplant…
View article: Recurrence of Drug-Induced Lupus Secondary to Vedolizumab Use in a Patient With Crohn's Disease
Recurrence of Drug-Induced Lupus Secondary to Vedolizumab Use in a Patient With Crohn's Disease Open
Drug-induced lupus is an autoimmune phenomenon characterized by the development of systemic lupus erythematosus–like clinical features after drug exposure. The entity is a clinical diagnosis. Evaluation consists of recognizing systemic lup…
View article: Validation of a Computationally Efficient Model of the Mu-Opioid Receptor
Validation of a Computationally Efficient Model of the Mu-Opioid Receptor Open
The mu-opioid receptor (MOR) is a transmembrane protein and the primary target for pain-modulating drugs. Opioid drugs come with detrimental side-effects such as physical dependence and addiction. However, recent studies show that understa…
View article: Pulmonary hypertension in hereditary hemorrhagic telangiectasia: A clinical review
Pulmonary hypertension in hereditary hemorrhagic telangiectasia: A clinical review Open
Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant hereditary disorder characterized by recurrent spontaneous epistaxis, mucocutaneous telangiectasias, and solid organ arteriovenous malformations (AVMs). Pulmonary hyp…
View article: Clinical presentation and neurovascular manifestations of cardiac myxomas and papillary fibroelastomas: a retrospective single-institution cohort study
Clinical presentation and neurovascular manifestations of cardiac myxomas and papillary fibroelastomas: a retrospective single-institution cohort study Open
Background Primary cardiac tumors are often benign and commonly present as cardiac myxomas (CMs) or papillary fibroelastomas (CPFEs). There is a paucity of prognostic indicators for tumor burden or potential for embolic cerebrovascular eve…
View article: Perforation of the Transverse Colon After Migration of a Ventriculoperitoneal Shunt
Perforation of the Transverse Colon After Migration of a Ventriculoperitoneal Shunt Open
A man in his forties with a history of multiple ventriculoperitoneal shunt (VPS) placements presented to the hospital for abdominal pain. Abdominal/pelvic computed tomography revealed the VPS entering the abdomen and extending along the re…
View article: Systemic capillary leak syndrome secondary to decompression sickness
Systemic capillary leak syndrome secondary to decompression sickness Open
Systemic capillary leak syndrome is a rare derangement of endothelial function characterised by extravasation of plasma and proteins into the interstitial space. Primary capillary leak syndrome is a rare, episodic medical illness of unknow…
View article: Immune-mediated herb-induced liver injury: a potential association with herbal artemisinin use as supported by the updated RUCAM
Immune-mediated herb-induced liver injury: a potential association with herbal artemisinin use as supported by the updated RUCAM Open
Immune-mediated herb-induced liver injury (HILI) is an acute or chronic inflammatory liver disease precipitated by a hepatotoxic agent with a presentation similar to acute autoimmune hepatitis. It is distinguished in clinical course from t…
View article: Importance of carbohydrate antigen (CA 19-9) and carcinoembrionic antigen (CEA) in the prognosis of patients with duodenal adenocarcinoma: a retrospective single-institution cohort study
Importance of carbohydrate antigen (CA 19-9) and carcinoembrionic antigen (CEA) in the prognosis of patients with duodenal adenocarcinoma: a retrospective single-institution cohort study Open
In summary, CA 19-9 and, to a lesser extent, CEA, show promise as prognostic markers in DA. Larger studies are needed to validate their use and to evaluate their performance as markers of recurrence.
View article: Addendum: Importance of carbohydrate antigen (CA 19-9) and carcinoembrionic antigen (CEA) in the prognosis of patients with duodenal adenocarcinoma: a retrospective single-institution cohort study
Addendum: Importance of carbohydrate antigen (CA 19-9) and carcinoembrionic antigen (CEA) in the prognosis of patients with duodenal adenocarcinoma: a retrospective single-institution cohort study Open
View article: Advanced Hepatocellular Carcinoma in Adults Without Cirrhosis: A Single-Institution Retrospective Review
Advanced Hepatocellular Carcinoma in Adults Without Cirrhosis: A Single-Institution Retrospective Review Open
Our findings suggest that unresectable NCHCC and CHCC have unique characteristics but similar overall survival. To the best of our knowledge, this is the largest comparison of CHCC and NCHCC.
View article: Clinical characteristics, prognostic factors, and long‐term outcomes associated with epithelial malignancies of the thymus: A 20‐year single‐institution experience
Clinical characteristics, prognostic factors, and long‐term outcomes associated with epithelial malignancies of the thymus: A 20‐year single‐institution experience Open
Background Thymic epithelial tumors are rare and include thymomas and thymic carcinomas. There is scarce literature characterizing prognostic factors and long‐term outcomes in these tumors. Aims This review aims to describe disease feature…
View article: Precapillary pulmonary arterial hypertension in a patient with Proteus syndrome
Precapillary pulmonary arterial hypertension in a patient with Proteus syndrome Open
Proteus syndrome is a rare progressive multisystem disorder characterized by asymmetric, disproportionate overgrowth of bone, skin, and other tissue types. Molecular pathogenesis has been identified as somatic activating mutations of the A…
View article: Management of adrenal insufficiency in the setting of chronic HIV and advanced extra-adrenal Hodgkin lymphoma
Management of adrenal insufficiency in the setting of chronic HIV and advanced extra-adrenal Hodgkin lymphoma Open
Adrenal insufficiency is one of the most common endocrine disorders that presents in patients with HIV. Aetiologies of adrenal dysfunction include opportunistic infection, malignancy, such as lymphoma or Kaposi sarcoma, and chronic cytokin…
View article: Diffuse hepatocellular carcinoma secondary to cardiac cirrhosis in heterotaxy syndrome
Diffuse hepatocellular carcinoma secondary to cardiac cirrhosis in heterotaxy syndrome Open
Heterotaxy syndrome is a rare congenital defect of left-right laterality of major visceral organs, often categorised by the presence of symmetric left or right atrial heart chambers with a single effective ventricle. Known as left or right…
View article: Synchronous Recto-Sigmoid Colorectal Carcinomas With Microsatellite Instability and an Activating PIK3CA Mutation
Synchronous Recto-Sigmoid Colorectal Carcinomas With Microsatellite Instability and an Activating PIK3CA Mutation Open
Synchronous colorectal cancer is a rare subtype of colorectal carcinoma defined by the presence of 2 or more primary tumors simultaneously or within 6 months of initial detection. The overall impact of a synchronous presentation on prognos…
View article: Publisher Correction: Automatic Choroid Layer Segmentation from Optical Coherence Tomography Images Using Deep Learning
Publisher Correction: Automatic Choroid Layer Segmentation from Optical Coherence Tomography Images Using Deep Learning Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Automatic Choroid Layer Segmentation from Optical Coherence Tomography Images Using Deep Learning
Automatic Choroid Layer Segmentation from Optical Coherence Tomography Images Using Deep Learning Open
View article: An All-Atomistic Molecular Dynamics Study to Determine the Structural Importance of Disulfide Bonds in Immunoglobulin G and Bovine Serum Albumin
An All-Atomistic Molecular Dynamics Study to Determine the Structural Importance of Disulfide Bonds in Immunoglobulin G and Bovine Serum Albumin Open
A fully-atomistic molecular dynamics study was performed to determine the importance of disulfide bonds on the stability of immunoglobulin G (IgG) and bovine serum albumin (BSA).The transferability of a previous prescreening methodology to…
View article: Volume 15, Issue 1
Volume 15, Issue 1 Open
A fully-atomistic molecular dynamics study was performed to determine the importance of disulfide bonds on the stability of immunoglobulin G (IgG) and bovine serum albumin (BSA).The transferability of a previous prescreening methodology to…