Akashi Taguchi
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View article: <i>Hox</i> – <i>Meis</i> -relayed topographical genetic switch underlies cardiopharyngeal neural crest diversification, revealed by multimodal analysis
<i>Hox</i> – <i>Meis</i> -relayed topographical genetic switch underlies cardiopharyngeal neural crest diversification, revealed by multimodal analysis Open
Neural crest cells (NCCs) are multipotent migratory cells essential for cardiac development, yet the lineage trajectories and gene regulatory networks (GRNs) underlying their intracardiac differentiation remain unclear. Here, we integrate …
View article: Novel therapy for gastric cancer peritoneal dissemination using genetically modified dental pulp cells and astatine-211
Novel therapy for gastric cancer peritoneal dissemination using genetically modified dental pulp cells and astatine-211 Open
SUMMARY Peritoneal dissemination of gastric cancer is a terminal stage with limited treatment options and a five-year survival rate below 10%. To develop a more effective treatment, we created a new approach that uses genetically engineere…
View article: Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression
Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression Open
Introduction A prior retrospective analysis demonstrated that quantifying Programmed Cell Death Ligand 1 (PD-L1) expression using a phosphor-integrated dot (PID) score effectively predicted immune checkpoint inhibitor (ICI) efficacy in non…
View article: Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulation
Offspring metabolic programming via the maternal diet increases susceptibility to metabolic dysregulation Open
View article: Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids
Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids Open
The effects of low-dose radiation on undifferentiated cells carry important implications. However, the effects on developing retinal cells remain unclear. Here, we analyzed the gene expression characteristics of neuronal organoids containi…
View article: Cardiac neural crest lineage diversity and underlying gene regulatory networks revealed by multimodal analysis
Cardiac neural crest lineage diversity and underlying gene regulatory networks revealed by multimodal analysis Open
Neural crest cells (NCCs), a multipotent stem cell population, contribute to cardiac development as a source of the outflow septum, vascular smooth muscle and semilunar valves. However, genetic programs underlying lineage diversification o…
View article: Eggshell membrane modulates gut microbiota to prevent murine pre‐cachexia through suppression of T helper cell differentiation
Eggshell membrane modulates gut microbiota to prevent murine pre‐cachexia through suppression of T helper cell differentiation Open
Background Cachexia is a life‐threatening condition observed in several pathologies, such as cancer or chronic diseases. Interleukin 10 ( Il10 ) gene transfer is known to improve cachexia by downregulating Il6 . Here, we used an IL10‐knock…
View article: The serological diversity of serum IgG/IgA/IgM against SARS‐CoV‐2 nucleoprotein, spike, and receptor‐binding domain and neutralizing antibodies in patients with COVID‐19 in Japan
The serological diversity of serum IgG/IgA/IgM against SARS‐CoV‐2 nucleoprotein, spike, and receptor‐binding domain and neutralizing antibodies in patients with COVID‐19 in Japan Open
Background We compared the temporal changes of immunoglobulin M (IgM), IgG, and IgA antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) nucleoprotein (N), spike 1 subunit (S1), and receptor‐binding domain (RBD),…
View article: Inhibition of cardiac PERK signaling promotes peripartum cardiac dysfunction
Inhibition of cardiac PERK signaling promotes peripartum cardiac dysfunction Open
Peripartum cardiomyopathy (PPCM) is a life-threatening heart failure occurring in the peripartum period. Although mal-angiogenesis, induced by the 16-kDa N-terminal prolactin fragment (16 K PRL), is involved in the pathogenesis, the effect…
View article: The serological diversity of serum IgG/IgA/IgM against the SARS-CoV-2 nucleoprotein, spike, and receptor-binding domain and neutralizing antibodies in patients with COVID-19 in Japan
The serological diversity of serum IgG/IgA/IgM against the SARS-CoV-2 nucleoprotein, spike, and receptor-binding domain and neutralizing antibodies in patients with COVID-19 in Japan Open
Objectives To compare the temporal changes of IgM, IgG, and IgA antibodies against the SARS-CoV-2 nucleoprotein, S1 subunit, and receptor binding domain and neutralizing antibodies (NAbs) against SARS-CoV-2 in patients with COVID-19. Metho…
View article: Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury
Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury Open
Significance Statement The detailed role of neural activity in inflammatory diseases is still unclear because it varies according to the disease situation and responsible cell types. This study shows that activation of β 2-adrenergic recep…
View article: Perk-Mediated Suppression of Micrornas by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure
Perk-Mediated Suppression of Micrornas by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure Open
View article: MicroRNA-320a/b is a Therapeutic Target and Biomarker for Peripartum Cardiomyopathy
MicroRNA-320a/b is a Therapeutic Target and Biomarker for Peripartum Cardiomyopathy Open
View article: Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster
Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster Open
View article: PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure
PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure Open
View article: Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells Open
View article: Lysine demethylase 7a regulates the anterior-posterior development in mouse by modulating the transcription of<i>Hox</i>gene cluster
Lysine demethylase 7a regulates the anterior-posterior development in mouse by modulating the transcription of<i>Hox</i>gene cluster Open
SUMMARY Temporal and spatial colinear expression of the Hox genes determines the specification of positional identities during vertebrate development. Post-translational modifications of histones contribute to transcriptional regulation. L…
View article: Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells Open
SUMMARY Lysine 9 di-methylation and lysine 27 tri-methylation of histone H3 (H3K9me2 and H3K27me3) are generally linked to gene repression. However, the functions of repressive histone methylation dynamics during inflammatory responses rem…
View article: Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells
Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells Open
View article: Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver
Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver Open
These results indicate that changes in the gene expression induced by K-877 treatment are mainly mediated through PPARα activation. K-877 regulates the hepatic gene expression as a SPPARMα and thus may improve dyslipidemia as well as metab…