Akbar Dorgalaleh
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View article: International Council for Standardization in Haematology (<scp>ICSH</scp>) Guidance on the Validation of Laboratory Developed Tests in Haemostasis
International Council for Standardization in Haematology (<span>ICSH</span>) Guidance on the Validation of Laboratory Developed Tests in Haemostasis Open
Laboratory developed tests (LDTs) are widely used in clinical hemostasis laboratories. An LDT may be defined as an in vitro diagnostic (IVD) test that is designed, manufactured, and used within a single laboratory. As with all other clinic…
View article: Natural Anticoagulant Protein Levels in Patients With Beta-Thalassemia Major: A Case-Control Study
Natural Anticoagulant Protein Levels in Patients With Beta-Thalassemia Major: A Case-Control Study Open
It seems that β-TM patients who receive prolonged blood transfusions frequently are at an increased risk of decreased in natural anticoagulants levels and therefore potentially are at risk of thrombosis.
View article: Protein S Deficiency with Two Novel PROS1 Gene Variants
Protein S Deficiency with Two Novel PROS1 Gene Variants Open
Background and Aims: Protein S (PS) is a vitamin K-dependent glycoprotein synthesized by endothelial and somatic cells that acts as an anticoagulant in its free form and an inhibitor of the complement system in its bound form. Deficiency o…
View article: International Council for Standardization in Haematology Guidance for New Lot Verification of Coagulation Reagents, Calibrators, and Controls
International Council for Standardization in Haematology Guidance for New Lot Verification of Coagulation Reagents, Calibrators, and Controls Open
The clinical laboratory uses commercial products with limited shelf life or certain expiry dates requiring frequent lot changes. Prior to implementation for clinical use, laboratories should determine the performance of the new reagent lot…
View article: Evaluating the Potential Blood Coagulant Activity of<i>Caenothus american</i>us Compounds: Computational Analysis using Docking, Physicochemical, and ADMET Studies
Evaluating the Potential Blood Coagulant Activity of<i>Caenothus american</i>us Compounds: Computational Analysis using Docking, Physicochemical, and ADMET Studies Open
Caenothus americanus is a common folk remedy for the treatment of wound bleeding. Certain compounds found in this plant have been shown to reduce clotting time. However, analyzing the effects of various compounds of a folk remedy is a time…
View article: Prevalence of Acute Complications of Transfusion in Children with β-thalassemia Major in Southeast Iran: A Prospective Study
Prevalence of Acute Complications of Transfusion in Children with β-thalassemia Major in Southeast Iran: A Prospective Study Open
Background: Acute complications of transfusion are among the leading causes of morbidity and mortality in chronically transfused patients. One of the main goals of blood transfusion is to reduce complications and improve blood safety and p…
View article: Interleukin 10, but not tumor necrosis factor-alpha, gene variations are associated with factor VII inhibitor development
Interleukin 10, but not tumor necrosis factor-alpha, gene variations are associated with factor VII inhibitor development Open
Objective Development of alloantibodies against coagulation factor VII (FVII) is the main therapeutic challenge in severe congenital FVII deficiency. About 7% of patients with severe congenital FVII deficiency develop an inhibitor against …
View article: Status of major hemostatic components in the setting of COVID-19: the effect on endothelium, platelets, coagulation factors, fibrinolytic system, and complement
Status of major hemostatic components in the setting of COVID-19: the effect on endothelium, platelets, coagulation factors, fibrinolytic system, and complement Open
View article: The Relationship between Inflammatory Cytokines and Coagulopathy in Patients with COVID-19
The Relationship between Inflammatory Cytokines and Coagulopathy in Patients with COVID-19 Open
Coronavirus disease 2019 (COVID-19), with a broad range of clinical and laboratory findings, is currently the most prevalent medical challenge worldwide. In this disease, hypercoagulability and hyperinflammation, two common features, are a…
View article: International Council for Standardization in Haematology (ICSH) laboratory guidance for the verification of haemostasis analyser‐reagent test systems. Part 2: Specialist tests and calibrated assays
International Council for Standardization in Haematology (ICSH) laboratory guidance for the verification of haemostasis analyser‐reagent test systems. Part 2: Specialist tests and calibrated assays Open
Before a new method is used for clinical testing, it is essential that it is evaluated for suitability for its intended purpose. This document gives guidance for the performance, verification and implementation processes required by regula…
View article: Clinical phenotype, fibrinogen supplementation, and health-related quality of life in patients with afibrinogenemia
Clinical phenotype, fibrinogen supplementation, and health-related quality of life in patients with afibrinogenemia Open
Due to the low prevalence of afibrinogenemia, epidemiologic data on afibrinogenemia are limited, and no data are available on health-related quality of life (HRQoL). We conducted a cross-sectional international study to characterize the cl…
View article: Inhibitor in Congenital Factor VII Deficiency; a Rare but Serious Therapeutic Challenge—A Systematic Literature Review
Inhibitor in Congenital Factor VII Deficiency; a Rare but Serious Therapeutic Challenge—A Systematic Literature Review Open
Background: Congenital factor (F) VII deficiency is a rare coagulation factor deficiency with an estimated incidence of 1 per 500,000 individuals. Patients with severe FVII deficiency present a broad range of clinical presentations. Alloim…
View article: Do congenital bleeding disorders have a protective effect against COVID‐19? A prospective study
Do congenital bleeding disorders have a protective effect against COVID‐19? A prospective study Open
The authors have no competing interests. Data are available upon request.
View article: International Council for Standardization in Haematology (ICSH) laboratory guidance for the evaluation of haemostasis analyser‐reagent test systems. Part 1: Instrument‐specific issues and commonly used coagulation screening tests
International Council for Standardization in Haematology (ICSH) laboratory guidance for the evaluation of haemostasis analyser‐reagent test systems. Part 1: Instrument‐specific issues and commonly used coagulation screening tests Open
Before a new method is used for clinical testing, it is essential that it is evaluated for suitability for its intended purpose. This document gives guidance for the performance of verification, validation and implementation processes requ…
View article: Prenatal Diagnosis of Congenital Factor XIII Deficiency Using Cell-Free Fetal DNA (cffDNA)
Prenatal Diagnosis of Congenital Factor XIII Deficiency Using Cell-Free Fetal DNA (cffDNA) Open
The authors have requested that this preprint be removed from Research Square.
View article: Mining of mortality-related findings in rare bleeding disorders: a retrospective study from two centers
Mining of mortality-related findings in rare bleeding disorders: a retrospective study from two centers Open
BACKGROUND: Rare bleeding disorders include inherited coagulation disorders except for von Willebrand disease and hemophilia A and B. These disorders affect both men and women worldwide and mainly have an autosomal recessive pattern of inh…
View article: How to Assess Founder Effect in Patients with Congenital Factor XIII Deficiency
How to Assess Founder Effect in Patients with Congenital Factor XIII Deficiency Open
Congenital factor XIII (FXIII) deficiency is an extremely rare bleeding disorder (RBD) with estimated prevalence of one per 2 million in the general population. The disorder causes different clinical manifestations such as intracranial hem…
View article: Standardization of Prothrombin Time/International Normalized Ratio (PT/INR)
Standardization of Prothrombin Time/International Normalized Ratio (PT/INR) Open
The prothrombin time (PT) represents the most commonly used coagulation test in clinical laboratories. The PT is mathematically converted to the international normalized ratio (INR) for use in monitoring anticoagulant therapy with vitamin …
View article: Gastrointestinal bleeding in a newborn infant with congenital factor X deficiency and COVID‐19—A common clinical feature between a rare disorder and a new, common infection
Gastrointestinal bleeding in a newborn infant with congenital factor X deficiency and COVID‐19—A common clinical feature between a rare disorder and a new, common infection Open
Dear Editors, Congenital factor X (FX) deficiency is an extremely rare, bleeding disorder with an estimated incidence of one per 1 million. Patients with severe FX deficiency (FX:C < 1%) demonstrate a wide spectrum of serious clinical pres…
View article: Patients with Congenital Bleeding Disorders Appear to be Less Severely Affected by SARS-CoV-2: Is Inherited Hypocoagulability Overcoming Acquired Hypercoagulability of Coronavirus Disease 2019 (COVID-19)?
Patients with Congenital Bleeding Disorders Appear to be Less Severely Affected by SARS-CoV-2: Is Inherited Hypocoagulability Overcoming Acquired Hypercoagulability of Coronavirus Disease 2019 (COVID-19)? Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the gravest current challenge worldwide, with approximately 5 million infected patients, more than 300,000 deaths, and an overall mortality rate of approximately 7% …
View article: Bleeding and Bleeding Risk in COVID-19
Bleeding and Bleeding Risk in COVID-19 Open
Coronavirus disease 2019 (COVID-19) is a new, emerging medical challenge worldwide, with those affected showing a variety of clinical presentations, ranging from asymptomatic or mild conditions to critical illness. Patients affected by the…
View article: Prevalence of Rare and Common Bleeding Disorders in Kurdistan Province of Iran
Prevalence of Rare and Common Bleeding Disorders in Kurdistan Province of Iran Open
Background: Congenital bleeding disorders (CBD) are a group of coagulopathies with different clinical and laboratory features. The prevalence of these disorders in different parts of the world is variable. Iran as a country with a high rat…
View article: Anticoagulation therapy in Iran
Anticoagulation therapy in Iran Open
Thromboembolic disorders are among the leading causes of morbidity and mortality in Iran. Anticoagulation therapy of affected patients is achieved using a variety of agents, including vitamin K antagonists (VKAs), heparin, and direct oral …
View article: International Council for Standardization in Haematology Recommendations for Hemostasis Critical Values, Tests, and Reporting
International Council for Standardization in Haematology Recommendations for Hemostasis Critical Values, Tests, and Reporting Open
This guidance document was prepared on behalf of the International Council for Standardization in Haematology (ICSH), the aim of which is to provide hemostasis-related guidance documents for clinical laboratories. The current ICSH document…
View article: First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran
First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran Open
Since TTIs are more common among first-time blood donors than regular and repeat donors, special considerations should be taken into account for this common group of blood donors.
View article: Congenital Prothrombin Deficiency
Congenital Prothrombin Deficiency Open
Congenital prothrombin deficiency is an extremely rare hemorrhagic disorder with estimated prevalence of 1 per 2,000,000 in the general population. Since the disorder is an autosomal recessive disorder, the disorder is more frequent in are…
View article: Expression and CpG island methylation pattern of MMP-2 and MMP-9 genes in patients with congenital factor XIII deficiency and intracranial hemorrhage
Expression and CpG island methylation pattern of MMP-2 and MMP-9 genes in patients with congenital factor XIII deficiency and intracranial hemorrhage Open
Our findings indicated that MMP-9 over-expression might be related to ICH in FXIII deficiency, and gene methylation effectively regulates its expression. Future researches will expand our understanding of the pathogenesis of ICH in …
View article: The Effect of Demographic Factors and VKORC1 1639 G>A Genotypes on Estimated Warfarin Maintenance Dose in Iranian Patients Under Warfarin Therapy
The Effect of Demographic Factors and VKORC1 1639 G>A Genotypes on Estimated Warfarin Maintenance Dose in Iranian Patients Under Warfarin Therapy Open
View article: Prenatal diagnosis in rare bleeding disorders—An unresolved issue?
Prenatal diagnosis in rare bleeding disorders—An unresolved issue? Open
Intracranial haemorrhage ( ICH ) is the most dreadful complication, and the main cause of death among patients with rare bleeding disorders ( RBD ) and prenatal diagnosis ( PND ) is a preventative lifesaving program. A total of 39 PND s we…
View article: Von Willebrand disease in Iran: diagnosis and management
Von Willebrand disease in Iran: diagnosis and management Open
von Willebrand disease (VWD) is the most common inherited bleeding disorder, and is classified into quantitative (type 1 and type 3) and qualitative (type 2) defects. The bleeding tendency is variable among affected patients, ranging from …