Akbar Waheed
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View article: A Laboratory-Based Experimental Study on the Protective Effects Against Isoniazid- Induced Hepatotoxicity in Mice
A Laboratory-Based Experimental Study on the Protective Effects Against Isoniazid- Induced Hepatotoxicity in Mice Open
Objective: To evaluate the role of Alpha Lipoic Acid (ALA) as a potential antidote to isoniazid-induced hepatitis.Study Design: Laboratory-based experimental animal study.Place and Duration of Study: The study was conducted at the Departme…
View article: FTO Gene rs9939609 is Potentially Associated with Diabetes Related Complications in T2DM Patients
FTO Gene rs9939609 is Potentially Associated with Diabetes Related Complications in T2DM Patients Open
Introduction: FTO gene rs9939609, an obesity susceptible gene, has strong with type 2 diabetes mellitus (T2DM). Studies have also established an association between the FTO gene rs9939609 and cardiovascular disease (CVD). This research inv…
View article: Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder
Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder Open
gov/ct2/show/NCT05931965.
View article: Evaluation of the Role of Losartan in the Prevention of Benign Prostate Hyperplasia in Rats
Evaluation of the Role of Losartan in the Prevention of Benign Prostate Hyperplasia in Rats Open
Objective: To evaluate the preventive role of Losartan in testosterone-induced Benign Prostate Hyperplasia in an adult rat model. Study Design: Laboratory-based experimental study. Place and Duration of Study: National Institute for Health…
View article: Dexmedetomidine leads to the amelioration of stress response to surgery
Dexmedetomidine leads to the amelioration of stress response to surgery Open
Objectives: To determine the impact of intravenous Dexmedetomidine (Dex) administered perioperatively on stress response markers in patients undergoing ENT surgeries. Methods: This randomized interventional study was conducted at POFs Hosp…
View article: Association of Genetic Polymorphism rs 77630697(Gly64Asp) of Multidrug and Toxin Extrusion -1 with glycemic response to metformin in patients with Type 2 Diabetes Mellitus
Association of Genetic Polymorphism rs 77630697(Gly64Asp) of Multidrug and Toxin Extrusion -1 with glycemic response to metformin in patients with Type 2 Diabetes Mellitus Open
Objective: To determine the relationship between Gly64Asp (rs77630697) polymorphism of multidrug and toxin extrusion-1 (MATE-1) and therapeutic response of metformin in Type-2 diabetic patients. Methods: A longitudinal study was conducted …
View article: Evaluation and Comparison of the Preventive Role of Nebivolol and Alpha- Tocopherol in Testosterone-Induced Benign Prostatic Hyperplasia in Rats
Evaluation and Comparison of the Preventive Role of Nebivolol and Alpha- Tocopherol in Testosterone-Induced Benign Prostatic Hyperplasia in Rats Open
Objective: To evaluate and compare the preventive role of Nebivolol and Alpha Tocopherol on testosterone-induced benign prostatic hyperplasia in rats. Study Design: Laboratory-based experimental study Place and Duration of Study: Departmen…
View article: Impact of CYP3A4 rs2242480 polymorphisms on Imatinib HPLC determined trough concentration and response in Chronic Myeloid Leukaemia in Pakistani patients
Impact of CYP3A4 rs2242480 polymorphisms on Imatinib HPLC determined trough concentration and response in Chronic Myeloid Leukaemia in Pakistani patients Open
Objective To ascertain the impact of CYP3A4 polymorphism on the therapeutic outcome of imatinib and its trough concentration Study design Descriptive analytical study Place and duration of the study This study was conducted in the Departme…
View article: PROTECTIVE EFFECTS OF SILYMARIN AND CHOLCALCIFEROL ON ISONIAZID INDUCED HEPATOTOXICITY IN MICE
PROTECTIVE EFFECTS OF SILYMARIN AND CHOLCALCIFEROL ON ISONIAZID INDUCED HEPATOTOXICITY IN MICE Open
Background: Hepatotoxicity is the gravest concern associated with use of anti-tuberculous drugs. The objective of this study was to evaluate the individual and combined hepatoprotective effect of silymarin and cholecalciferol in isoniazid …
View article: Fat Mass and Obesity‐Related (FTO) Gene Variant Is a Predictor of CVD in T2DM Patients
Fat Mass and Obesity‐Related (FTO) Gene Variant Is a Predictor of CVD in T2DM Patients Open
Background: The role of the common FTO gene variant rs9939609 in obesity has been well established, and the FTO gene has a strong association with T2DM. Objective: To investigate the association of FTO gene variant rs9939609 with obesity‐r…
View article: EFFECTS OF WALNUT LEAVES EXTRACT ON EFFICACY OF DAPAGLIFLOZIN IN TYPE II DIABETIC MICE
EFFECTS OF WALNUT LEAVES EXTRACT ON EFFICACY OF DAPAGLIFLOZIN IN TYPE II DIABETIC MICE Open
Background: With a rising prevalence of type 2 diabetes mellitus its becoming more important than ever to find new strategies to prevent and cure the disease. Objective of this study was to assess the effects of walnut leaves extract on th…
View article: Unraveling Catechol-O-Methyltransferase rs4680 SNP’s Role in Patients’ Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management
Unraveling Catechol-O-Methyltransferase rs4680 SNP’s Role in Patients’ Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management Open
Effective postoperative pain management is essential for patient well-being and an efficient healthcare system. Variations in the Catechol O-Methyltransferase (COMT) gene, specifically rs4680, play a crucial role in pain perception and opi…
View article: Cytochrome P-450 CYP2C19 genetic polymorphism and its relation with clopidogrel resistance
Cytochrome P-450 CYP2C19 genetic polymorphism and its relation with clopidogrel resistance Open
Objectives: To find out the prevalence of CYP2C19*2 genetic polymorphism in ischemic heart disease patients, and to determine its relation with clopidogrel resistance in different genotype groups. Method: The cross-sectional study was cond…
View article: THE ROLE OF OPRM1 (rs1799971) GENETIC VARIANT IN MODULATING THE ANALGESIC EFFECT OF TRAMADOL IN POSTOPERATIVE PAIN
THE ROLE OF OPRM1 (rs1799971) GENETIC VARIANT IN MODULATING THE ANALGESIC EFFECT OF TRAMADOL IN POSTOPERATIVE PAIN Open
Objective: This pioneering study aims to understand the influence of genetic polymorphism identified as rs1799971 in the exon 1 of mu-opioid receptor (OPRM1) gene on the safety and efficacy of tramadol in context to postoperative pain with…
View article: Imatinib resistance in CML and its association with age & gender.
Imatinib resistance in CML and its association with age & gender. Open
Objective: To evaluate the association of gender and age with the resistance shown to Imatinib in CML with evaluation of WBCC in different age groups. Study Design: Cross Sectional Analytical study. Setting: Islamic International Medical C…
View article: COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA Open
Sciatica, a musculoskeletal condition is a common cause of disability and early deaths, affecting millions of people globally. The aim of the study was to evaluate efficacy of different drug combinations for treatment of acute sciatica. It…
View article: Effects of body mass index on propofol-induced cardiovascular depression in the Pakistani population
Effects of body mass index on propofol-induced cardiovascular depression in the Pakistani population Open
Objective: To determine the relationship between the patient’s Body Mass Index (BMI) and the cardiovascular effects produced by propofol at a dose of 1.5 mg/kg in the Pakistani population.
Methods: This descriptive cross-sectional study w…
View article: Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats
Comparative effects of parsley leaves aqueous extract and ramipril on gentamicin induced nephrotoxicity in rats Open
BACKGROUND & OBJECTIVE: Rats are commonly used in experimental studies as they have a smaller body size, they are easily available, and their genetic profiles are similar to each other as compared to humans. Kidney pathologies are the resu…
View article: Glycemic Response to Metformin and Its Association with Age and Gender in Type II Diabetes
Glycemic Response to Metformin and Its Association with Age and Gender in Type II Diabetes Open
Diabetes Mellitus has become a global health concern due to its continued rise in prevalence. According to International Diabetic Federation (IDF), Type II diabetes mellitus (T2DM) currently affects 462 million people worldwide and is expe…
View article: Evaluation of impact of pharmaceutical care services on cardiologist adherence to hypertension Guidelines JNC 7: A critical prospect for rational use of drugs in Pakistan
Evaluation of impact of pharmaceutical care services on cardiologist adherence to hypertension Guidelines JNC 7: A critical prospect for rational use of drugs in Pakistan Open
Purpose: To assess the adherence of cardiologists to JNC7 and the impact of pharmacists in reducing clinical inertia by managing high blood pressure in the cardiology out-patient department of the Armed Forces Institute of Cardiolo…
View article: COMPARISON OF EFFECTS OF PROBIOTICS AND SITAGLIPTIN ON SERUM GLUCOSE IN DIABETIC RATS
COMPARISON OF EFFECTS OF PROBIOTICS AND SITAGLIPTIN ON SERUM GLUCOSE IN DIABETIC RATS Open
Background: Diabetes mellitus has become a major disease having catastrophic effects on health and economy globally. This study was conducted to determine the role of Probiotics in comparison to Sitagliptin in decreasing serum glucose leve…
View article: Anti-Obesity Effects of Aloe Vera Whole Leaf and Sitagliptin in Diabetic Rats
Anti-Obesity Effects of Aloe Vera Whole Leaf and Sitagliptin in Diabetic Rats Open
Background: Aloe Vera, a medicinal herb, has been used for centuries in therapeutics and cosmetology. Objective: To compare Antiobesity effects of Aloe Vera whole leaf with new antidiabetic drug, Sitagliptin on streptozotcin induced diabet…
View article: Antidiabetic Effects of Aloe Vera Whole Leaf Extract and Sitagliptin in Streptozotocin-induced Diabetic Rats
Antidiabetic Effects of Aloe Vera Whole Leaf Extract and Sitagliptin in Streptozotocin-induced Diabetic Rats Open
Introduction: Aloe Vera, a perennial herb, is being used since ancient times for the cure of various diseases and is recently being used in curing diabetes due to the synergistic activity of its over 75 biologically active ingredients. The…
View article: Comparison of hepatoprotective effect of aqueous and ethanolic extracts of Berberis lycium Royale (Sumbloo) in isoniazid induced hepatotoxicity in male mice model
Comparison of hepatoprotective effect of aqueous and ethanolic extracts of Berberis lycium Royale (Sumbloo) in isoniazid induced hepatotoxicity in male mice model Open
Background: The objective of the study was to compare the hepatoprotective effect of aqueous and ethanolic extracts of stem bark of Berberis lycium Royle in isoniazid (INH) induced hepatotoxicity in mice model.Methods: This randomized cont…
View article: TO EVUALATE THE AMELIORATIVE ROLE OF VITAMIN E ON NEPHROTOXICITY INDUCED BY VANCOMYCIN IN RABBITS
TO EVUALATE THE AMELIORATIVE ROLE OF VITAMIN E ON NEPHROTOXICITY INDUCED BY VANCOMYCIN IN RABBITS Open
Objective: To analyze the ameliorative effects of vitamin E on vancomycin-induced nephrotoxicity in rabbits. Study Design: Laboratory based experimental study. Place and Duration of Study: National Institute of Health, Islamabad and Depart…
View article: Adequacy of phosphodiesterase inhibitor in prevention and treatment of LPS induced organ failure in BALB/c mice
Adequacy of phosphodiesterase inhibitor in prevention and treatment of LPS induced organ failure in BALB/c mice Open
Background: Even though with immense improvement and extensive understanding of pathophysiology of sepsis induced organ failure and affected population, it continues to put hundreds of people worldwide to eternal sleep due to lack of targe…
View article: POST-OPERATIVE PATIENTS;
POST-OPERATIVE PATIENTS; Open
Objective: To explore the effect of genetic polymorphism -100_-102AAG deletion in the 5-hydroxytryptamine type 3B (5-HT3B) gene on the incidence of post-operative vomiting (POV). Study Design: A prospective, clinical trial. Place and Durat…
View article: STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS
STUDY OF PREVENTIVE EFFECT OF MELATONIN ON HIGH DOSE VANCOMYCIN INDUCED NEPHROTOXICITY IN RABBITS Open
Objective: To explore the nephropreventive effects of melatonin on vancomycin-induced nephrotoxicity in rabbits. Study Design: Laboratory based randomized controlled trial. Place and Duration of Study: Department of Pharmacology and Therap…
View article: LIVER INJURY
LIVER INJURY Open
Methimazole (MMI) is a widely used antithyroid drug for hyperthyroidism.However its clinical use is associated with many deleterious effects including hepatotoxicity.MMI induced liver injury is dependent upon bio-activation to toxic interm…
View article: ASPIRIN RESISTANCE: AN EMERGING THREAT TO CARDIOVASCULAR DISEASE PATIENTS AND ITS ASSOCIATION WITH AGE AND GENDER
ASPIRIN RESISTANCE: AN EMERGING THREAT TO CARDIOVASCULAR DISEASE PATIENTS AND ITS ASSOCIATION WITH AGE AND GENDER Open
Objective: To examine the existence of pharmacological aspirin resistance andits association with age and gender in cardiovascular disease patients. Methodology: This cross sectional study was conducted from October 2015 toDecember 201…