Akemi Tomoda
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View article: Establishing reference values for normal tongue squamous cells: An investigation of atypical changes
Establishing reference values for normal tongue squamous cells: An investigation of atypical changes Open
Objective: In cytological evaluation, atypical cells are often recognized by comparing them to presumed “normal” counterparts and judging the extent of morphological deviation. However, there is no clear or universally accepted definition …
View article: Multi-epigenome-wide analyses and meta-analysis of child maltreatment in judicial autopsies and intervened children and adolescents
Multi-epigenome-wide analyses and meta-analysis of child maltreatment in judicial autopsies and intervened children and adolescents Open
Child maltreatment (CM) is associated with adverse physical, psychological, and neurodevelopmental outcomes later in life. Epigenetic modifications, particularly DNA methylation, have been proposed as potential mechanisms underlying these …
View article: Behavioral and emotional difficulties in maltreated children: Associations with epigenetic clock changes and visual attention to social cues
Behavioral and emotional difficulties in maltreated children: Associations with epigenetic clock changes and visual attention to social cues Open
Research indicates that childhood maltreatment leads to adverse outcomes later in life and accelerated aging. However, few studies have investigated how age acceleration manifests during childhood. This study aimed to investigate the impac…
View article: Assessing childhood maltreatment exposure using the child behavior checklist
Assessing childhood maltreatment exposure using the child behavior checklist Open
Introduction Childhood maltreatment (CM) has broad and severe adverse effects in later life, but there are not enough studies conducted during childhood close to the time of maltreatment. Most studies have focused only on a single symptom …
View article: White-Matter fiber tract and resting-state functional connectivity abnormalities in young children with autism spectrum disorder
White-Matter fiber tract and resting-state functional connectivity abnormalities in young children with autism spectrum disorder Open
Autism spectrum disorder (ASD) is a complex developmental disorder characterized by difficulties in social interaction and communication and repetitive behaviors. Although abnormal brain development has been shown to exist in children with…
View article: Application of the ORBEYE Three-Dimensional Exoscope for Parotidectomies
Application of the ORBEYE Three-Dimensional Exoscope for Parotidectomies Open
Background/Objectives: Parotid surgery is generally performed with the naked eye or using surgical loupes. However, this approach has technical disadvantages. Therefore, this study aimed to compare the use of an exoscope with that of loupe…
View article: Brain structure characteristics in children with attention-deficit/hyperactivity disorder elucidated using traveling-subject harmonization
Brain structure characteristics in children with attention-deficit/hyperactivity disorder elucidated using traveling-subject harmonization Open
Background Brain imaging studies for attention-deficit/hyperactivity disorder (ADHD) have not always yielded consistent findings, potentially owing to measurement bias in magnetic resonance imaging (MRI) scanners. This study aimed to eluci…
View article: Corrigendum: Effect of the nature of subsequent environment on oxytocin and cortisol secretion in maltreated children
Corrigendum: Effect of the nature of subsequent environment on oxytocin and cortisol secretion in maltreated children Open
[This corrects the article DOI: 10.3389/fpsyt.2015.00173.].
View article: A pragmatic randomised controlled trial of the effectiveness and cost‐effectiveness of Well Parent Japan in routine care in Japan: The training and nurturing support for mothers (TRANSFORM) study
A pragmatic randomised controlled trial of the effectiveness and cost‐effectiveness of Well Parent Japan in routine care in Japan: The training and nurturing support for mothers (TRANSFORM) study Open
Background Well Parent Japan (WPJ) is a new hybrid group parent training programme combining sessions to improve mothers' psychological well‐being with a culturally adapted version of the New Forest Parenting Programme (NFPP). This study i…
View article: Brain structures and functional connectivity in neglected children with no other types of maltreatment
Brain structures and functional connectivity in neglected children with no other types of maltreatment Open
Child maltreatment can adversely affect brain development, leading to vulnerabilities in brain structure and function and various psychiatric disorders. Among the various types of child maltreatment, neglect has the highest incidence rate …
View article: The neurobiological effects of childhood maltreatment on brain structure, function, and attachment
The neurobiological effects of childhood maltreatment on brain structure, function, and attachment Open
Childhood maltreatment is a risk factor for psychopathologies, and influences brain development at specific periods, particularly during early childhood and adolescence. This narrative review addresses phenotypic alterations in sensory sys…
View article: Diffusion tensor imaging of white-matter structural features of maltreating mothers and their associations with intergenerational chain of childhood abuse
Diffusion tensor imaging of white-matter structural features of maltreating mothers and their associations with intergenerational chain of childhood abuse Open
Child abuse causes lifelong adverse outcomes for both physical and mental health, although many are resilient. Efforts to prevent this issue from the parental side require an understanding of the neurobiological basis that leads abusive pa…
View article: Data Science Using the Human Epigenome for Predicting Multifactorial Diseases and Symptoms
Data Science Using the Human Epigenome for Predicting Multifactorial Diseases and Symptoms Open
Tweetable abstract This article reviews machine learning models that leverages epigenomic data for predicting multifactorial diseases and symptoms as well as how such models can be utilized to explore new research questions.
View article: Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study – RETRACTION
Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study – RETRACTION Open
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View article: Effect of regulating Piezo2 expression in DRG on core phenotype, S1 and mPFC neuron functions in ASD mouse model
Effect of regulating Piezo2 expression in DRG on core phenotype, S1 and mPFC neuron functions in ASD mouse model Open
Background Tactile overreaction (TOR) in the symptoms of autism spectrum disorder (ASD) has attracted attention because of its high incidence and potential influence on the core phenotype. However, the possible causes of TOR are unclear. P…
View article: Multi-Epigenome-Wide Analyses and Meta-Analysis of Child Maltreatment in Judicial Autopsies and Intervened Children and Adolescents
Multi-Epigenome-Wide Analyses and Meta-Analysis of Child Maltreatment in Judicial Autopsies and Intervened Children and Adolescents Open
Child maltreatment (CM) leads to adverse outcomes in later life. We describe the epigenome-wide analyses and meta-analysis results of three original cohorts consisting of judicially or socially certified CM cases and controls to gain furth…
View article: Subclinical structural atypicality of the retinal thickness and association with gray matter volume of the visual cortex in maltreated children
Subclinical structural atypicality of the retinal thickness and association with gray matter volume of the visual cortex in maltreated children Open
Individuals who experienced childhood maltreatment reportedly have atypical gray matter structures in their primary visual cortex (V1). Thus, we hypothesized that the sensory structures of vision may also be affected by these influences an…
View article: Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach
Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach Open
Introduction Neuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have demonstrated differences in extensive brain structure, activity and network. However, there remains heterogeneity …
View article: Evaluation of the pooled sample method in Infinium Methylation EPIC Bead Chip array by comparison with individual samples
Evaluation of the pooled sample method in Infinium Methylation EPIC Bead Chip array by comparison with individual samples Open
Background: The pooled sample method is used in epigenomic research and expression analysis and is a cost-effective screening approach. Evaluation of the pooled sample method in epigenomic studies is performed using the Illumina Infinium M…