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View article: <scp>IMPDH</scp> and <scp>GTP</scp> Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope
<span>IMPDH</span> and <span>GTP</span> Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope Open
Guanosine triphosphate (GTP) is increasingly recognized as a critical actor in cancer cell proliferation, yet its regulatory mechanism remains incompletely defined. A key contributor to elevated GTP levels in tumors is inosine monophosphat…
View article: <scp>PI</scp>5<scp>P</scp>4<scp>K</scp> inhibitors: promising opportunities and challenges
<span>PI</span>5<span>P</span>4<span>K</span> inhibitors: promising opportunities and challenges Open
Phosphatidylinositol 5‐phosphate 4‐kinases (PI5P4K), also known as type II PIPKs or PIPKIIs, convert the lipid second messenger PI5P to PI(4,5)P 2 . The PI5P4K family consists of three isozymes in mammals—PI5P4Kα, β, and γ—which notably ut…
View article: Toceranib phosphate (Palladia) reverses type 1 diabetes by preserving islet function in mice
Toceranib phosphate (Palladia) reverses type 1 diabetes by preserving islet function in mice Open
In recent years, strategies targeting β-cell protection via autoimmune regulation have been suggested as novel and potent immunotherapeutic interventions against type 1 diabetes mellitus (T1D). Here, we investigated the potential of tocera…
View article: Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer
Anti-CCR4 treatment depletes regulatory T cells and leads to clinical activity in a canine model of advanced prostate cancer Open
Background Targeting regulatory T cell (Treg) infiltration is an emerging strategy for cancer immunotherapy. However, its efficacy in advanced prostate cancer remains unclear. Here, we showed the therapeutic efficacy of anti-Treg treatment…
View article: CCR4 blockade leads to clinical activity and prolongs survival in a canine model of advanced prostate cancer
CCR4 blockade leads to clinical activity and prolongs survival in a canine model of advanced prostate cancer Open
Targeting regulatory T cell (Treg) infiltration is an emerging strategy for cancer immunotherapy. However, the efficacy of this strategy in advanced prostate cancer remains unclear. Here, we describe the therapeutic efficacy of this strate…
View article: Isolated growth hormone deficiency in a Chihuahua with a <i>GH1</i> mutation
Isolated growth hormone deficiency in a Chihuahua with a <i>GH1</i> mutation Open
A 6-mo-old female Chihuahua was presented with recurrent episodes of hypoglycemia and collapse. Physical examination revealed proportionate dwarfism, retained puppy hair coat, retained deciduous teeth, and open fontanelles. Routine blood t…
View article: A Double‐blind, Placebo‐controlled, Multicenter, Prospective, Randomized Study of Beraprost Sodium Treatment for Cats with Chronic Kidney Disease
A Double‐blind, Placebo‐controlled, Multicenter, Prospective, Randomized Study of Beraprost Sodium Treatment for Cats with Chronic Kidney Disease Open
Background Chronic kidney disease (CKD) is a common progressive and irreversible disease in cats. The efficacy and safety of beraprost sodium (BPS) in cats with CKD have not been evaluated. Hypothesis/Objectives To evaluate the efficacy an…