Aki Kurosaki
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View article: Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT
Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT Open
Background Transgenic (Tg) mice are widely used in biomedical research, and they are typically generated by injecting transgenic DNA cassettes into pronuclei of one-cell stage zygotes. Such animals often show unreliable expression of the t…
View article: Delivering mRNAs to mouse tissues using the SEND system
Delivering mRNAs to mouse tissues using the SEND system Open
mRNAs produced in a cell are almost always translated within the same cell. Some mRNAs are transported to other cells of the organism through processes involving membrane nanotubes or extracellular vesicles. A recent report describes a sur…
View article: Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools
Novel reporter mouse models useful for evaluating in vivo gene editing and for optimization of methods of delivering genome editing tools Open
The clustered regularly interspersed palindromic repeats (CRISPR) system is a powerful genome-editing tool to modify genomes, virtually in any species. The CRISPR tool has now been utilized in many areas of medical research, including gene…