Akihiko Saitoh
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View article: Parechovirus-A3 Infection in Neonates and Young Infants from the Pre-Coronavirus Disease 2019 Pandemic Period to the Post-Restriction Era from the Pediatric Parechovirus Surveillance Group in Japan
Parechovirus-A3 Infection in Neonates and Young Infants from the Pre-Coronavirus Disease 2019 Pandemic Period to the Post-Restriction Era from the Pediatric Parechovirus Surveillance Group in Japan Open
Background The coronavirus disease 2019 (COVID-19) pandemic affected the epidemiology of community-acquired infectious diseases; however, the data on the effects of the pandemic on parechovirus-A3 (PeV-A3) circulation remain incomplete. Me…
View article: Fatal acute fulminant cerebral edema complicating Kawasaki disease in an infant: a case report
Fatal acute fulminant cerebral edema complicating Kawasaki disease in an infant: a case report Open
View article: A novel method for generating chimeric antigen receptor-transduced primary human natural killer cells by the use of multiple cytokines and anti-CD2 and anti-NKp46 stimulatory antibodies
A novel method for generating chimeric antigen receptor-transduced primary human natural killer cells by the use of multiple cytokines and anti-CD2 and anti-NKp46 stimulatory antibodies Open
Allogenic chimeric antigen receptor (CAR)-transduced natural killer (NK) cells have garnered attention due to their efficacy, safety, and potential off-the-shelf nature in patients with refractory and relapsed hematological malignancies. H…
View article: Revisiting Hepatic Fibrosis Risk in Congenital Heart Disease: Insights from Non-Invasive Markers and Echocardiography
Revisiting Hepatic Fibrosis Risk in Congenital Heart Disease: Insights from Non-Invasive Markers and Echocardiography Open
Background/Objectives: This study aimed to investigate the prevalence of liver damage and its associated non-invasive markers and echocardiographic risk factors in patients who underwent surgery for congenital heart disease. Methods: This …
View article: Corrigendum to “Comparison of Clinical Characteristics of Hospitalized Pediatric Patients with Respiratory Syncytial Virus Infections before and during/after the Coronavirus Disease 2019 Pandemic in Japan -Importance of Universal Prevention using Maternal Vaccination and Nirsevimab” [J Infect Chemother 31 (2025) 102779]
Corrigendum to “Comparison of Clinical Characteristics of Hospitalized Pediatric Patients with Respiratory Syncytial Virus Infections before and during/after the Coronavirus Disease 2019 Pandemic in Japan -Importance of Universal Prevention using Maternal Vaccination and Nirsevimab” [J Infect Chemother 31 (2025) 102779] Open
View article: Chimeric PD‑1 receptor redirects primary T cells against childhood solid tumors but not to PD‑1 ligand‑positive CD80‑coexpressing cells
Chimeric PD‑1 receptor redirects primary T cells against childhood solid tumors but not to PD‑1 ligand‑positive CD80‑coexpressing cells Open
The clinical application of T cells engineered with chimeric antigen receptors (CARs) for solid tumors is challenging. A major reason for this involves tumor immune evasion mechanisms, including the high expression of immune checkpoint mol…
View article: Nationwide population-based surveillance of invasive pneumococcal disease in children in Japan (2014–2022): Impact of 13-valent pneumococcal conjugate vaccine and COVID-19 pandemic
Nationwide population-based surveillance of invasive pneumococcal disease in children in Japan (2014–2022): Impact of 13-valent pneumococcal conjugate vaccine and COVID-19 pandemic Open
PCV13 introduction and the COVID-19 pandemic have had a significant impact on pediatric IPD in Japan. It is important to continuously monitor the epidemiological characteristics of pediatric IPD after the introduction of PCV20.
View article: Sustained Maternal Antibodies Against Parechovirus‐A3 During the Coronavirus Disease 2019 Pandemic
Sustained Maternal Antibodies Against Parechovirus‐A3 During the Coronavirus Disease 2019 Pandemic Open
The epidemiology of parechovirus‐A3 (PeV‐A3) infection in neonates and young infants changed during the coronavirus disease 2019 (COVID‐19) pandemic. We hypothesized the pandemic impacted maternal antibodies against PeV‐A3. To test this hy…
View article: Burden of rotavirus and other microorganisms in hospitalized children with acute gastroenteritis in Yangon, Myanmar, before the introduction of rotavirus vaccine
Burden of rotavirus and other microorganisms in hospitalized children with acute gastroenteritis in Yangon, Myanmar, before the introduction of rotavirus vaccine Open
Rotavirus is the predominant pathogen associated with AGE in hospitalized children in Myanmar. The introduction of a rotavirus vaccine will reduce the morbidity and mortality of children with rotavirus-associated AGE in Myanmar.
View article: P-1210. Resurgence of Parechovirus-A3 Infection in Neonates and Young Infants after the Coronavirus Disease 2019 Pandemic in Japan
P-1210. Resurgence of Parechovirus-A3 Infection in Neonates and Young Infants after the Coronavirus Disease 2019 Pandemic in Japan Open
Background Parechovirus-A (PeV-A), especially PeV-A3, is a common cause of viral sepsis and encephalitis in neonates and young infants (age < 4 months). The strict infection control measures and non-pharmaceutical interventions of the c…
View article: P-869. Comparison of β-lactams Antibiotics Resistance of Viridans Streptococci in Bacteremic Children and Adults with Malignancy
P-869. Comparison of β-lactams Antibiotics Resistance of Viridans Streptococci in Bacteremic Children and Adults with Malignancy Open
Background Viridans streptococcus bacteremia (VSB) is an important complication after receiving chemotherapy in patients with malignancy. The increase in antibiotic resistance treating patients with VSB has been a major concern especially …
View article: P-1191. Maternal Antibodies Against Parechovirus-A3 Before and During the Coronavirus Disease 2019 Pandemic
P-1191. Maternal Antibodies Against Parechovirus-A3 Before and During the Coronavirus Disease 2019 Pandemic Open
Background Parechovirus-A3 (PeV-A3) is an important emerging virus that causes severe disease in neonates and young infants. The coronavirus disease 2019 (COVID-19) pandemic greatly affected the incidence of infectious diseases, including …
View article: 222. Effectiveness of the Original BNT162b2 Messenger RNA Vaccine Against COVID-19 Omicron Infection in Children Aged 6 Months to 4 Years in Japan
222. Effectiveness of the Original BNT162b2 Messenger RNA Vaccine Against COVID-19 Omicron Infection in Children Aged 6 Months to 4 Years in Japan Open
Background The coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were confirmed to be safe and effective, and the original BNT162b2 mRNA vaccine for children aged 6 months to 4 years was introduced in October 2022. However,…
View article: Nationwide Population-Based Surveillance of Invasive Pneumococcal Disease in Children in Japan (2014–2022): Impact of 13-Valent Pneumococcal Conjugate Vaccine and Covid-19 Pandemic
Nationwide Population-Based Surveillance of Invasive Pneumococcal Disease in Children in Japan (2014–2022): Impact of 13-Valent Pneumococcal Conjugate Vaccine and Covid-19 Pandemic Open
View article: Vaccination Education Deficits and Vaccine Hesitancy Among Healthcare Students in Japan: A Cross-Sectional Study
Vaccination Education Deficits and Vaccine Hesitancy Among Healthcare Students in Japan: A Cross-Sectional Study Open
Background/Objectives: Healthcare professionals’ (HCPs’) accurate knowledge of and positive attitudes toward immunization greatly influence society’s acceptance of it. Early and appropriate immunization education for HCP students is vital.…
View article: Cardiac resynchronization therapy by pacing the right ventricular dorsal site of inflow and anterior outflow for congenitally corrected transposition of the great arteries: a case report
Cardiac resynchronization therapy by pacing the right ventricular dorsal site of inflow and anterior outflow for congenitally corrected transposition of the great arteries: a case report Open
Background Evidence regarding cardiac resynchronization therapy (CRT) for congenitally corrected transposition of the great arteries (ccTGA) is insufficient. The timing to perform CRT and optimal pacing sites have not been systematically s…
View article: Preterm Infant with Generalized Arterial Calcification of Infancy Who Survived Due to Early Diagnosis and Appropriate Treatment with Bisphosphonates: A Case Report
Preterm Infant with Generalized Arterial Calcification of Infancy Who Survived Due to Early Diagnosis and Appropriate Treatment with Bisphosphonates: A Case Report Open
Generalized arterial calcification of infancy (GACI) is a rare disease characterized by arterial calcification. GACI is caused by a mutation in the ENPP1 or ABCC6 genes. GACI causes severe hypertension and heart failure, and approximately …
View article: Fatal SARS-CoV-2 Infection Among Children, Japan, January–September 20221
Fatal SARS-CoV-2 Infection Among Children, Japan, January–September 20221 Open
To determine the characteristics of pediatric patients 0-19 years of age who died after onset of SARS-CoV-2 infection in Japan during January 1-September 30, 2022, we reviewed multiple sources. We identified 62 cases, collected detailed in…
View article: Successful oral midodrine therapy for treatment of refractory postoperative chylothorax in an infant
Successful oral midodrine therapy for treatment of refractory postoperative chylothorax in an infant Open
Refractory chylothorax, a postoperative complication of CHD, is difficult to manage and sometimes fatal. Herein, we report the case of a 10-month-old infant with 22-mosaic trisomy and a coarctation complex, who developed refractory chyloth…
View article: Over-investigation and overtreatment in pediatrics: a survey from the European Academy of Paediatrics and Japan Pediatric Society
Over-investigation and overtreatment in pediatrics: a survey from the European Academy of Paediatrics and Japan Pediatric Society Open
Introduction Avoiding over-investigation and overtreatment in health care is a challenge for clinicians across the world, prompting the international Choosing Wisely campaign. Lists of recommendations regarding medical overactivity are hel…
View article: Detection of enterovirus D68 among children with severe acute respiratory infection in Myanmar
Detection of enterovirus D68 among children with severe acute respiratory infection in Myanmar Open
To our knowledge, this is the first report of EV-D68 detection in children with acute lower respiratory infections in Yangon, Myanmar, in 2017-2018. Detection and detailed virologic analyses of EV-D68 in southeast Asia is an important aspe…
View article: Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan
Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan Open
Central congenital hypothyroidism (CH) can occur as an isolated deficiency or as part of combined pituitary hormone deficiency. Unlike primary CH, central CH cannot be detected by newborn screening (NBS) using dry filter paper blood TSH le…
View article: ICE volume 45 issue 1 Cover and Front matter
ICE volume 45 issue 1 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Effective mentoring in pediatrics
Effective mentoring in pediatrics Open
Peer Reviewed
View article: 1739. Mumps Vaccine Hesitancy: Current Evidence and An Evidence-Based Campaign in Japan
1739. Mumps Vaccine Hesitancy: Current Evidence and An Evidence-Based Campaign in Japan Open
Background Mumps is still endemic in Japan because mumps vaccination is voluntary. In this study, we investigated associations of parental socioeconomic status, family structure, and knowledge/belief about mumps and mumps vaccine with pare…
View article: 2355. Incidence of Omicron Variant Reinfection and Reduction of Reinfection Risk After Coronavirus Disease 2019 Vaccination in Children
2355. Incidence of Omicron Variant Reinfection and Reduction of Reinfection Risk After Coronavirus Disease 2019 Vaccination in Children Open
Background Reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become an important concern after the emergence of SARS-CoV-2 omicron variants (e.g., BA.1, BA.2, and BA.5). Reinfection by variants can occur in ch…
View article: Regression of kaposiform lymphangiomatosis and chronic disseminated intravascular coagulation after inhaled budesonide-formoterol treatment
Regression of kaposiform lymphangiomatosis and chronic disseminated intravascular coagulation after inhaled budesonide-formoterol treatment Open
Regression of kaposiform lymphangiomatosis and chronic disseminated intravascular coagulation after inhaled budesonide-formoterol treatmentMasaru Imamura1, Chansu Shin1, Akihiko Saitoh1, Michio Ozeki 2, Kentaro Matsuoka3 Chihaya Imai11Depa…
View article: Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome
Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome Open
Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder characterized by combined immunodeficiency, eczema, microthrombocytopenia, autoimmunity, and lymphoid malignancies. Gene therapy (GT) to modify autologous CD34+ cells is an emergin…
View article: An outbreak investigation of parechovirus-A3 in a newborn nursery
An outbreak investigation of parechovirus-A3 in a newborn nursery Open
Objective: To investigate parechovirus-A3 (PeV-A3) transmission in a newborn nursery, after encountering 3 neonates with fever and rash. Design: An observational study. Setting: At a newborn nursery at the general hospital in Hyogo, Japan.…
View article: Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry
Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry Open