Akihiko Soyama
YOU?
Author Swipe
View article: Reply to “Geographical Accessibility Does Not Affect Prognosis After Living‐Donor Liver Transplantation”
Reply to “Geographical Accessibility Does Not Affect Prognosis After Living‐Donor Liver Transplantation” Open
View article: Attempts to Establish a Helicobacter bilis Biliary Tract Infection Model via Oral Administration of Helicobacter bilis
Attempts to Establish a Helicobacter bilis Biliary Tract Infection Model via Oral Administration of Helicobacter bilis Open
Background Although several studies have reported an association between Helicobacter bilis (H. bilis) and human biliary tract cancer, in vivo studies are necessary to further assess this phenomenon. In this study, we develop…
View article: Corrigendum to ‘Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus’ [Regen Ther 30 (2025) 1–8]
Corrigendum to ‘Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus’ [Regen Ther 30 (2025) 1–8] Open
[This corrects the article DOI: 10.1016/j.reth.2025.04.015.].
View article: Protocol of the STRIDE-X study: a multicenter, single-arm trial of single tremelimumab regular interval durvalumab followed by hepatectomy for initially unresectable hepatocellular carcinoma
Protocol of the STRIDE-X study: a multicenter, single-arm trial of single tremelimumab regular interval durvalumab followed by hepatectomy for initially unresectable hepatocellular carcinoma Open
Background Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer globally and the third leading cause of cancer-related death. Systemic therapies such as lenvatinib or the combination of atezolizumab and bevacizumab has rece…
View article: Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis
Daikenchuto improves methotrexate-induced chronic small intestinal mucositis by promoting angiogenesis Open
Aim Chronic small-intestinal mucositis (CIM) is a severe gastrointestinal complication that has limited treatment options. This study investigated the potential therapeutic effects of Daikenchuto (DKT), a traditional medicine, on mitigatin…
View article: Association Between Distance to the Transplant Center and Survival Following Living Donor Liver Transplantation
Association Between Distance to the Transplant Center and Survival Following Living Donor Liver Transplantation Open
Aim To determine whether the distance from home to our transplant center affects posttransplant survival in patients undergoing living donor liver transplantation. Methods Data from 301 adult patients who underwent primary living donor liv…
View article: A Retrospective Study of the Usefulness of Partial Cystectomy for Advanced Colorectal Cancer With Bladder Invasion
A Retrospective Study of the Usefulness of Partial Cystectomy for Advanced Colorectal Cancer With Bladder Invasion Open
View article: Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus
Transplantation of chemically induced liver progenitors in Nagase analbuminemic rats under liver regenerative stimulus Open
View article: Living Donor Liver Transplantation with Small Left Lobe Grafts: Prospective Validation of Utility of Splenectomy in Selected Recipients
Living Donor Liver Transplantation with Small Left Lobe Grafts: Prospective Validation of Utility of Splenectomy in Selected Recipients Open
BACKGROUND We previously reported that the Model for End-stage Liver Disease (MELD) score and donor age are risk factors for small-for-size syndrome in adult living donor liver transplantation (LDLT) involving small grafts. Since April 202…
View article: Characteristics of chemically induced liver progenitors derived from a pig model of metabolic dysfunction-associated steatotic liver disease
Characteristics of chemically induced liver progenitors derived from a pig model of metabolic dysfunction-associated steatotic liver disease Open
We previously reported the efficacy of chemically induced liver progenitors (CLiP) as a source of cells for transplantation in patients with liver disease. This study aimed to characterize CLiP derived from steatotic livers using a pig mod…
View article: Mitigation of polystyrene microplastic-induced hepatotoxicity in human hepatobiliary organoids through bile extraction
Mitigation of polystyrene microplastic-induced hepatotoxicity in human hepatobiliary organoids through bile extraction Open
This study provides insights into the metabolic pathways of PS-MPs in the liver and suggests potential therapeutic strategies to reduce MP-induced liver damage.
View article: Five-item Modified Frailty Index in Elderly Patients Undergoing Laparoscopic Colorectal Surgery Predicts Postoperative Complications
Five-item Modified Frailty Index in Elderly Patients Undergoing Laparoscopic Colorectal Surgery Predicts Postoperative Complications Open
Background/Aim: Owing to underlying diseases and decreased physiological functions, frailty in elderly patients may be associated with adverse postoperative complications and mortality. To date, there are various frailty assessment methods…
View article: Characterizing alcohol-related and metabolic dysfunction-associated steatotic liver disease cirrhosis via fibrotic pattern analysis
Characterizing alcohol-related and metabolic dysfunction-associated steatotic liver disease cirrhosis via fibrotic pattern analysis Open
This study aimed to address the diagnostic challenges in distinguishing between alcohol-related liver disease (ALD) and metabolic dysfunction-associated steatotic liver disease (MASLD). We utilized whole-slide imaging technology to conduct…
View article: A prospective randomized controlled study to evaluate the efficacy of Daikenchuto in treating postoperative abdominal pain and bloating following hepatectomy
A prospective randomized controlled study to evaluate the efficacy of Daikenchuto in treating postoperative abdominal pain and bloating following hepatectomy Open
Although DKT did not significantly improve postoperative symptoms, such as abdominal pain or bloating, it is widely used in Japan to improve bowel movement and is safely prescribed for patients undergoing hepatectomy with a tendency toward…
View article: Clinical Outcomes and Histologic Findings of Patients With Hepatocellular Carcinoma With Durable Partial Response or Durable Stable Disease After Receiving Atezolizumab Plus Bevacizumab
Clinical Outcomes and Histologic Findings of Patients With Hepatocellular Carcinoma With Durable Partial Response or Durable Stable Disease After Receiving Atezolizumab Plus Bevacizumab Open
PURPOSE Durable partial response (PR) and durable stable disease (SD) are often seen in patients with hepatocellular carcinoma (HCC) receiving atezolizumab plus bevacizumab (atezo-bev). This study investigates the outcome of these patients…
View article: Generation of human hepatobiliary organoids with a functional bile duct from chemically induced liver progenitor cells
Generation of human hepatobiliary organoids with a functional bile duct from chemically induced liver progenitor cells Open
View article: Fully-Covered Self-Expandable Metal Stent for Hepaticojejunostomy Anastomotic Stricture After Living Donor Liver Transplantation: A Case Series
Fully-Covered Self-Expandable Metal Stent for Hepaticojejunostomy Anastomotic Stricture After Living Donor Liver Transplantation: A Case Series Open
FCSEMS placement may be effective and safe for HAS after LDLT, which is not resolved with conventional treatment using a plastic stent. MRCP should be used to identify HAS prior to invasive cholangiography.
View article: Open Abdominal Management for Damage Control in Liver Transplantation: A Single-center Experience
Open Abdominal Management for Damage Control in Liver Transplantation: A Single-center Experience Open
Background. Patients undergoing liver transplantation are in a state of coagulopathy before surgery because of liver failure. Intraoperative hemorrhage, massive transfusions, and post–reperfusion syndrome further contribute to coagulopathy…
View article: Minimally invasive pancreaticoduodenectomy for circumportal pancreas: literature review and report of two type IIIA cases
Minimally invasive pancreaticoduodenectomy for circumportal pancreas: literature review and report of two type IIIA cases Open
Background Circumportal pancreas is a rare morphological variant with clinical significance due to the high risk of postoperative pancreatic fistula in patients undergoing pancreaticoduodenectomy. Type IIIA (suprasplenic anteportal) is the…
View article: Repeated Minimally Invasive Pancreatectomy for Intraductal Papillary Mucinous Neoplasm in the Remnant Pancreas: A Case Report
Repeated Minimally Invasive Pancreatectomy for Intraductal Papillary Mucinous Neoplasm in the Remnant Pancreas: A Case Report Open
BACKGROUND Minimally invasive pancreatectomy has become the standard practice for the management of benign and malignant pancreatic tumors. Techniques such as robotic and laparoscopic approaches are known to reduce morbidity by offering be…
View article: Essential updates 2022/2023: A review of current topics in robotic hepatectomy
Essential updates 2022/2023: A review of current topics in robotic hepatectomy Open
The liver requires careful handling intra‐operatively owing to its vital functions and complexity. Traditional open hepatectomy, while standard, is invasive and requires long recovery periods. Laparoscopic hepatectomy is a less invasive op…
View article: Analysis of expression status and relationship between senescence- related genes and pancreatic function-related genes in human islets of various ages
Analysis of expression status and relationship between senescence- related genes and pancreatic function-related genes in human islets of various ages Open
Background Although studies on senescence-related genes using human islets have been performed, the expression of senescence-related genes and their association with functional genes in islets remain insufficiently investigated. We aimed t…
View article: Deceased donor liver transplantation for acute liver failure with coronavirus infection: a case report
Deceased donor liver transplantation for acute liver failure with coronavirus infection: a case report Open
2019年末に中国武漢で報告され，流行した新型コロナウイルス（以下COVID-19）感染症により，移植医療はレシピエントのCOVID-19感染，移植のための人の往来による感染伝播，移植後患者のCOVID-19感染のリスクなど様々な問題に直面した．実際に，それらの問題のため，COVID-19流行前の2019年と流行後の2020年以降2022年末までの臓器提供数，脳死肝移植症例数を比較すると，減少している．
View article: Fully-Covered Self-Expandable Metal Stent for Hepaticojejunostomy Anastomotic Stricture after Living Donor Liver Transplantation: A Case Series
Fully-Covered Self-Expandable Metal Stent for Hepaticojejunostomy Anastomotic Stricture after Living Donor Liver Transplantation: A Case Series Open
View article: Analysis of Expression Status and Relationship Between Senescence-related Genes and Pancreatic Function-related Genes in Human Islets of Langerhans from Donors of Various Ages
Analysis of Expression Status and Relationship Between Senescence-related Genes and Pancreatic Function-related Genes in Human Islets of Langerhans from Donors of Various Ages Open
We showed the functional potential even of aged islets, which were originally thought to be functionally impaired. We were unable to identify any senescence-related genes expressed in islets from donors of different ages. Therefore, a new …
View article: The impact of colonic allograft inclusion on intestinal transplantation outcomes: Results from UNOS/OPTN database analysis
The impact of colonic allograft inclusion on intestinal transplantation outcomes: Results from UNOS/OPTN database analysis Open
Background Outcomes of intestinal transplantation with colon allograft (ICTx) remain controversial. We aimed to assess the outcomes of ICTx in comparison to intestinal transplantation without colon (ITx) using the UNOS/OPTN registry databa…
View article: Living donor liver transplantation for a patient with acute liver failure following thyroid storm: a case report
Living donor liver transplantation for a patient with acute liver failure following thyroid storm: a case report Open
Background Thyroid storm can be complicated by liver dysfunction, which may occasionally progress to acute liver failure. We herein report a case of acute liver failure following thyroid storm that was treated with living donor liver trans…
View article: Serum wisteria floribunda agglutinin-positive human Mac-2 binding protein is unsuitable as a diagnostic marker of occult hepatocellular carcinoma in end-stage liver cirrhosis
Serum wisteria floribunda agglutinin-positive human Mac-2 binding protein is unsuitable as a diagnostic marker of occult hepatocellular carcinoma in end-stage liver cirrhosis Open
Background and purpose Serum glycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA + -M2BP) is a marker of liver fibrosis and hepatocellular carcinoma (HCC). In this study, we aimed to evaluate the diagnostic abil…
View article: Angioplasty of the inferior vena cava with a bovine pericardial patch by the modified open-chest dorsal approach for Budd-Chiari syndrome: A case report
Angioplasty of the inferior vena cava with a bovine pericardial patch by the modified open-chest dorsal approach for Budd-Chiari syndrome: A case report Open
The techniques described in this article include procedures that cardiovascular surgeons usually perform such as thoracotomy, pericardiotomy, and extracorporeal circulation. Collaborative work by hepatobiliary surgeons and cardiovascular s…
View article: Evolution of Liver Transplantation Over the Last 2 Decades Based on a Single-Center Experience of 300 Cases
Evolution of Liver Transplantation Over the Last 2 Decades Based on a Single-Center Experience of 300 Cases Open
BACKGROUND Over the past 2 decades, there have been many medical advances in the field of liver transplantation. We conducted this study to evaluate the changes in liver transplantation over the last 2 decades. MATERIAL AND METHODS Three h…