Akihiro Yamada
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View article: Radiotherapy‐Induced Pleural Mesothelioma in a Childhood Leukaemia Survivor: A Case Report
Radiotherapy‐Induced Pleural Mesothelioma in a Childhood Leukaemia Survivor: A Case Report Open
We report the case of a 41‐year‐old woman who developed an epithelioid‐type pleural mesothelioma (PM) decades after treatment for childhood acute myeloid leukaemia (AML), who was treated with chemotherapy and total body irradiation (TBI). …
View article: Early resolution of bowel urgency by budesonide foam enema results in improved quality of life in patients with ulcerative colitis: a multicenter prospective observational study
Early resolution of bowel urgency by budesonide foam enema results in improved quality of life in patients with ulcerative colitis: a multicenter prospective observational study Open
Background/Aims: Bowel urgency is an important symptom for quality of life determination in patients with ulcerative colitis (UC). Few clinical studies have focused on bowel urgency as an efficacy endpoint. Budesonide foam enema has shown …
View article: Clinical Pharmacology of the Antibody–Drug Conjugate Enfortumab Vedotin in Advanced Urothelial Carcinoma and Other Malignant Solid Tumors
Clinical Pharmacology of the Antibody–Drug Conjugate Enfortumab Vedotin in Advanced Urothelial Carcinoma and Other Malignant Solid Tumors Open
Enfortumab vedotin is an antibody-drug conjugate comprised of a human monoclonal antibody directed to Nectin-4 and monomethyl auristatin E (MMAE), a microtubule-disrupting agent. The objectives of this review are to summarize the clinical …
View article: P1189 Clinical features and surgical necessity rate of fistulising perianal disease in newly diagnosed patients with Crohn's disease: Interim analysis of inception cohort registry study of patients with Crohn's disease (iCREST-CD)
P1189 Clinical features and surgical necessity rate of fistulising perianal disease in newly diagnosed patients with Crohn's disease: Interim analysis of inception cohort registry study of patients with Crohn's disease (iCREST-CD) Open
Background Fistulising perianal diseases (FPD) are common in patients with Crohn's disease (CD) in Asia, but the treatment pattern and the proportion of patients who develop new FPD after diagnosis are not clear. An interim analysis of a l…
View article: Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5‐fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single‐center study
Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5‐fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single‐center study Open
Background Squamous cell carcinoma of the external auditory canal (EACSCC) is a rare condition. However, a standard treatment has not yet been established. We retrospectively evaluated the efficacy, adverse events, and feasibility of TPF‐C…
View article: Correction: Characteristics of adult patients newly diagnosed with Crohn’s disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn’s disease in Japan (iCREST-CD)
Correction: Characteristics of adult patients newly diagnosed with Crohn’s disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn’s disease in Japan (iCREST-CD) Open
View article: Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn’s Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn’s Disease (iCREST-CD)
Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn’s Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn’s Disease (iCREST-CD) Open
Background and Aims Perianal lesion is a refractory phenotype of Crohn’s disease [CD] with significantly diminished quality of life. We evaluated the clinical characteristics of perianal lesions in newly diagnosed CD patients and the impac…
View article: Single‐ and multiple‐dose safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of <scp>ASP0367</scp>, or bocidelpar sulfate, a novel modulator of peroxisome proliferator‐activated receptor delta in healthy adults: Results from a phase 1 study
Single‐ and multiple‐dose safety, tolerability, pharmacokinetic, and pharmacodynamic profiles of <span>ASP0367</span>, or bocidelpar sulfate, a novel modulator of peroxisome proliferator‐activated receptor delta in healthy adults: Results from a phase 1 study Open
Introduction/Aims ASP0367, or bocidelpar sulfate, is an orally administered small molecule that potently and selectively modulates peroxisome proliferator–activated receptor δ (PPARδ) to address mitochondrial dysfunction occurring in disea…
View article: P172 Clinical characteristics of newly diagnosed adult patients with Crohn’s disease in Japan: Interim analysis of Inception cohort registry study of patients with Crohn’s disease (iCREST-CD)
P172 Clinical characteristics of newly diagnosed adult patients with Crohn’s disease in Japan: Interim analysis of Inception cohort registry study of patients with Crohn’s disease (iCREST-CD) Open
Background Information on patient demographics and disease characteristics at the time of Crohn’s disease (CD) diagnosis is considered to be an important aspect in the treatment and management of CD. However, reports on phenotypes, disease…
View article: Supplementary Material for: The Correlation between Vitamin D Levels and the Risk of Postoperative Recurrence in Crohn’s Disease
Supplementary Material for: The Correlation between Vitamin D Levels and the Risk of Postoperative Recurrence in Crohn’s Disease Open
Background and Aims: Vitamin D deficiency has been associated with disease activity in Crohn’s disease (CD). We assessed whether there is a correlation between vitamin D levels and the risk of postoperative recurrence in CD. …
View article: Safety of nontumor necrosis factor‐targeted biologics in the COVID‐19 pandemic
Safety of nontumor necrosis factor‐targeted biologics in the COVID‐19 pandemic Open
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View article: The risk of respiratory tract infections and interstitial lung disease with interleukin 12/23 and interleukin 23 antagonists in patients with autoimmune diseases: A systematic review and meta-analysis
The risk of respiratory tract infections and interstitial lung disease with interleukin 12/23 and interleukin 23 antagonists in patients with autoimmune diseases: A systematic review and meta-analysis Open
View article: Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm
Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm Open
Drug development in oncology commonly exploits the tools of molecular biology to gain therapeutic benefit through reprograming of cellular responses. In immuno‐oncology (IO) the aim is to direct the patient’s own immune system to fight can…
View article: Low Skeletal Muscle Index Adjusted for Body Mass Index Is an Independent Risk Factor for Inflammatory Bowel Disease Surgical Complications
Low Skeletal Muscle Index Adjusted for Body Mass Index Is an Independent Risk Factor for Inflammatory Bowel Disease Surgical Complications Open
Background This study aims to evaluate sarcopenia defined by skeletal muscle index (SMI) with cutoffs adjusted for sex and body mass index as a predictive marker for postoperative outcomes among individuals with inflammatory bowel disease.…
View article: Systemic review and network meta-analysis: Prophylactic antibiotic therapy for spontaneous bacterial peritonitis
Systemic review and network meta-analysis: Prophylactic antibiotic therapy for spontaneous bacterial peritonitis Open
View article: Systemic review and network meta-analysis: Prophylactic antibiotic therapy for spontaneous bacterial peritonitis
Systemic review and network meta-analysis: Prophylactic antibiotic therapy for spontaneous bacterial peritonitis Open
The present comprehensive network meta-analysis provides RCT based evidence for superior efficacy of rifaximin compared to other antibiotics for the prophylaxis of SBP and reducing risk of death/transplant. Further RCTs are warranted to co…
View article: Monitored Anesthesia Care for a Patient with Chronic Spinal Cord Injury Undergoing Orchiectomy
Monitored Anesthesia Care for a Patient with Chronic Spinal Cord Injury Undergoing Orchiectomy Open
慢性期脊髄損傷患者の麻酔管理では，自律神経過反射（AD）が問題となる．症例は56歳，男性で第11胸髄以下の完全麻痺がある．左陰嚢膿瘍に対し精巣摘除術が予定された．日常生活でのADの既往はなく，今回膀胱内操作は行わないため，術中にADを発症する可能性は低いと考えた．無麻酔で手術を行うことも可能と考えられたが，AD発症への対応が遅れる可能性があったため，監視下鎮静管理（MAC）で行った．デクスメデトミジン（DEX）の持続投与とフェンタニルの間欠投与でBIS値35〜78，RASS…
View article: A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins
A Quantitative Systems Pharmacology Consortium Approach to Managing Immunogenicity of Therapeutic Proteins Open
Immunogenicity is a major challenge in drug development and patient care. Currently, most efforts are dedicated to the elimination of the unwanted immune responses through T-cell epitope prediction and protein engineering. However, because…
View article: 572 – Prophylactic Antibiotic Therapy for Spontaneous Bacterial Peritonitis: A Systemic Review and Network Meta-Analysis
572 – Prophylactic Antibiotic Therapy for Spontaneous Bacterial Peritonitis: A Systemic Review and Network Meta-Analysis Open
View article: Issue Information
Issue Information Open
Aims and Scope: For more than 50 years, clinical pharmacologists, clinical and pharmaceutical researchers, drug development specialists, physicians, nurses, and other medical professionals have relied on The Journal of Clinical Pharmacolog…
View article: Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease
Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease Open
H. pylori eradication therapy does not alter the short-term disease activity of IBD.
View article: A Phase 1, Multiple‐Dose Study of Vedolizumab in Japanese Patients With Ulcerative Colitis
A Phase 1, Multiple‐Dose Study of Vedolizumab in Japanese Patients With Ulcerative Colitis Open
Although previous studies have shown that patients with ulcerative colitis may benefit from treatment with vedolizumab, a humanized monoclonal antibody targeting the α 4 β 7 integrin heterodimer, no data exist in Japanese populations. The …
View article: A comparison of the risk of postoperative recurrence between African‐American and Caucasian patients with Crohn's disease
A comparison of the risk of postoperative recurrence between African‐American and Caucasian patients with Crohn's disease Open
Summary Background Many patients with Crohn's disease will develop complications that require surgery. Recurrence after surgery is common. Aim To assess racial differences in postoperative recurrence between African‐Americans and Caucasian…
View article: The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis
The prevalence of endoscopic gastric mucosal damage in patients with rheumatoid arthritis Open
Our findings suggest that PSL and NSAIDs were exacerbating factors for gastric mucosal damage, while PPIs usage was a protective factor. And, the combined usage of corticosteroids and NSAIDs may induce the development of gastric ulcers.
View article: Gastrointestinal cancer risk in cystic fibrosis: more exploration is needed – Authors' reply
Gastrointestinal cancer risk in cystic fibrosis: more exploration is needed – Authors' reply Open
View article: Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction
Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction Open
Background and Purpose Development of combination therapies has received significant interest in recent years. Previously, a two‐receptor one‐transducer (2R‐1T) model was proposed to characterize drug interactions with two receptors that l…
View article: Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape Open
A cross‐industry survey was conducted to assess the landscape of preclinical quantitative systems pharmacology (QSP) modeling within pharmaceutical companies. This article presents the survey results, which provide insights on the current …
View article: P153 The air-enema image of ultra-low-dose CT colonography can be an alternative diagnostic technique for the assessment of mucosal healing in the patients with ulcerative colitis
P153 The air-enema image of ultra-low-dose CT colonography can be an alternative diagnostic technique for the assessment of mucosal healing in the patients with ulcerative colitis Open
A “Treat to Target” approach has been proposed for ulcerative colitis (UC), with a target of combined clinical and endoscopic remission. However, endoscopy is invasive, time-consuming, and uncomfortable. Biomarkers like faecal calprotectin…
View article: Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial
Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial Open
contributed to improvements in patients' quality of life. 1 Many clinical observations have confirmed that anti-TNF-α mAbs are efficacious for the treatment of CD.Unfortunately, however, we are faced with a new complication: loss of respon…
View article: Risk Factors for Mortality in <b><i>Pneumocystis jirovecii</i></b> Pneumonia in Patients with Inflammatory Bowel Disease
Risk Factors for Mortality in <b><i>Pneumocystis jirovecii</i></b> Pneumonia in Patients with Inflammatory Bowel Disease Open
Background: Pneumocystis jirovecii pneumonia (PJP) is highly fatal once infection is established. In this study, we investigated the risk of PJP mortality in patients with inflammatory bowel disease (IBD). Method…