Akihisa Saito
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View article: Multiple simultaneous small intestinal diverticular penetrations
Multiple simultaneous small intestinal diverticular penetrations Open
Jejunal diverticulosis is a rare condition. Here, we report a rare case of multiple simultaneous small intestinal diverticular penetrations. An 82-year-old man was admitted with a chief complaint of slurred speech. The patient had fever an…
View article: TMPRSS4 as a prognostic biomarker after gastric cancer surgery in a multicenter retrospective study
TMPRSS4 as a prognostic biomarker after gastric cancer surgery in a multicenter retrospective study Open
Transmembrane protease serine 4 (TMPRSS4) is a member of the type II transmembrane serine protease family known to be upregulated in many malignancies. We previously showed that TMPRSS4 may be a prognostic biomarker and therapeutic target …
View article: A case report of anaplastic large cell lymphoma that developed during treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma
A case report of anaplastic large cell lymphoma that developed during treatment for chronic lymphocytic leukemia/small lymphocytic lymphoma Open
背景:慢性リンパ球性白血病/小リンパ球性リンパ腫(CLL/SLL)における未分化大細胞型リンパ腫(ALCL)の発症はまれである.今回,CLL/SLL の治療中に発生した ALCL の一例を経験したので報告する.
View article: Advanced gallbladder cancer accompanied with cancer-associated dermatomyositis: A case report and literature review
Advanced gallbladder cancer accompanied with cancer-associated dermatomyositis: A case report and literature review Open
Rationale: Muscle weakness due to cancer-associated dermatomyositis (CADM) can be misdiagnosed as cancer cachexia and disuse atrophy. Patient concerns: A 75-year-old female was admitted to our institute with muscle weakness, dysphagia, and…
View article: Histopathology and Cytology of Pulmonary Myoepithelial Neoplasms: 2 Cases
Histopathology and Cytology of Pulmonary Myoepithelial Neoplasms: 2 Cases Open
Myoepithelial neoplasms (MNs) of the lung are extremely rare tumors. Approximately 40 cases of pulmonary MNs have been reported to date. Herein, we report extremely rare cases of different types of pulmonary MN, including cytological featu…
View article: Transcriptomic Analysis of Annexin A10 and Chemosensitivity in Gastric Adenocarcinoma Cells
Transcriptomic Analysis of Annexin A10 and Chemosensitivity in Gastric Adenocarcinoma Cells Open
ANXA10 knockout increased the susceptibility of GC cell lines to 5-FU; ANXA10 may be a predictive indicator for response to 5-FU treatment in GC cases. ANXA10 may be involved in the pathogenesis of GC, in collaboration with CLDN1, KRT80, R…
View article: Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis
Pathogenesis of follicular thymic hyperplasia associated with rheumatoid arthritis Open
Lymphoproliferative disorders may occur in patients with rheumatoid arthritis (RA) who are treated with methotrexate. However, follicular thymic hyperplasia (FTH) associated with RA (FTH‐RA) is generally not considered a lymphoproliferativ…
View article: Bilateral malignant breast tumors containing pleomorphic liposarcoma components
Bilateral malignant breast tumors containing pleomorphic liposarcoma components Open
背景:両側乳房肉腫は,病因が不明なまれな悪性腫瘍である.今回われわれは,多形型脂肪肉腫成分を含む両側乳腺腫瘍の 1 例を経験したので報告する.
View article: P16‐4: Therapeutic effect of oligonucleotide therapeutics PK‐7010 in mouse model of bleomycin‐induced lung fibrosis
P16‐4: Therapeutic effect of oligonucleotide therapeutics PK‐7010 in mouse model of bleomycin‐induced lung fibrosis Open
in lung epithelial cells.These results suggested the possibility that ANGPTL4 secreted from lung epithelial cells might act on the fibroblasts and be involved in fibrotic processes.The levels of serum ANGPTL4 of AE-IPF were significantly e…
View article: Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer
Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer Open
TMPRSS4 can be considered as a potential prognostic biomarker, especially for stage III, and a promising therapeutic target for GC.
View article: Systemic Inflammatory Score Predicts Response and Prognosis in Patients With Lung Cancer Treated With Immunotherapy
Systemic Inflammatory Score Predicts Response and Prognosis in Patients With Lung Cancer Treated With Immunotherapy Open
SIS is a useful marker of the efficacy of immunotherapy that can be obtained via routine blood tests.
View article: Laparoscopic resection for a large gastrointestinal stromal tumor (GIST) with diaphragm invasion following preoperative imatinib treatment: A case report
Laparoscopic resection for a large gastrointestinal stromal tumor (GIST) with diaphragm invasion following preoperative imatinib treatment: A case report Open
This is the first report of a large gastric GIST invading the diaphragm that was successfully treated by laparoscopic resection after tumor reduction by neoadjuvant imatinib.
View article: Annexin A10 Expression Is Associated With Poor Prognosis in Small Bowel Adenocarcinoma
Annexin A10 Expression Is Associated With Poor Prognosis in Small Bowel Adenocarcinoma Open
ANXA10 could be a new prognostic biomarker for SBA.
View article: Anterior Mediastinal Leiomyosarcoma: A Case Report and Literature Review
Anterior Mediastinal Leiomyosarcoma: A Case Report and Literature Review Open
Primary mediastinal sarcomas are extremely rare. Additionally, mediastinal leiomyosarcomas account for approximately 9% of mediastinal sarcoma cases. Until date, only few cases of anterior mediastinal leiomyosarcomas have been reported. He…
View article: Nuclear grade and comedo necrosis of ductal carcinoma <i>in situ</i> as histopathological eligible criteria for the Japan Clinical Oncology Group 1505 trial: an interobserver agreement study
Nuclear grade and comedo necrosis of ductal carcinoma <i>in situ</i> as histopathological eligible criteria for the Japan Clinical Oncology Group 1505 trial: an interobserver agreement study Open
Objective The Japan Clinical Oncology Group 1505 trial is a single-arm multicentre prospective study that examined the possibility of non-surgical follow-up with endocrine therapy for patients with low-grade ductal carcinoma in situ. In th…
View article: Intramucosal Poorly Differentiated Adenocarcinomas Detected in a Patient with Long-Standing Ulcerative Colitis
Intramucosal Poorly Differentiated Adenocarcinomas Detected in a Patient with Long-Standing Ulcerative Colitis Open
We report a case of long-standing ulcerative colitis with intramucosal well- and poorly differentiated adenocarcinomas detected over a 6-month duration. A Japanese man in his sixties with a 31-year history of ulcerative colitis had a 1.1-c…
View article: Loss of Annexin A10 Expression Is Associated with Poor Prognosis in Early Gastric Cancer
Loss of Annexin A10 Expression Is Associated with Poor Prognosis in Early Gastric Cancer Open
Gastric cancer (GC) is the third most common cause of cancer-related mortality. The diagnosis and treatment of early GC is a crucial strategy for prognostic improvement of GC. Annexin A10 (ANXA10), a calcium-/phospholipid-binding protein, …
View article: CD204-Positive Tumor-associated Macrophages Relate to Malignant Transformation of Colorectal Adenoma
CD204-Positive Tumor-associated Macrophages Relate to Malignant Transformation of Colorectal Adenoma Open
CD204 (+) TAM is a novel component in the malignant transformation of colorectal adenoma.
View article: A case of pilomatricoma with suspected malignancy diagnosed by intraoperative rapid cytological diagnosis
A case of pilomatricoma with suspected malignancy diagnosed by intraoperative rapid cytological diagnosis Open
背景 : 毛母腫は, 小児や若年成人に好発する良性皮膚付属器腫瘍であり, 細胞診において誤診が生じる可能性が高い腫瘍とされている.