Akiko Sugiyama
YOU?
Author Swipe
View article: Upregulation of the lncRNA <i>XACT</i> sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cells
Upregulation of the lncRNA <i>XACT</i> sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cells Open
Summary Long noncoding RNAs (lncRNAs) represent a vast class of regulatory transcripts and are spatiotemporally controlled, yet only a few have been functionally implicated in human development. Here, we identify the X-linked lncRNA XACT ,…
View article: The Visualization of Nocturnal Scratching Behavior in Pediatric Atopic Dermatitis: Facilitating Shared Decision-Making and Assessing the Efficacy of Treatment
The Visualization of Nocturnal Scratching Behavior in Pediatric Atopic Dermatitis: Facilitating Shared Decision-Making and Assessing the Efficacy of Treatment Open
Itching is a subjective symptom that is especially difficult to assess in pediatric atopic dermatitis (AD) patients with chronic pruritus since early infancy. This study aimed to assess the utility of the Itch Tracker (Maruho Co. Ltd., Osa…
View article: Phase II multicenter clinical trial of hypoallergenic 1BS-18 Hokushin bread oral immunotherapy for wheat-dependent exercise-induced anaphylaxis
Phase II multicenter clinical trial of hypoallergenic 1BS-18 Hokushin bread oral immunotherapy for wheat-dependent exercise-induced anaphylaxis Open
Background: Therapies for desensitizing wheat-dependent exercise-induced anaphylaxis (WDEIA), a severe allergic response to wheat ingestion and exercise, remain unestablished. This study aimed to investigate whether continuous ingestion of…
View article: Three cases in which vNOTES was tried but could not be completed
Three cases in which vNOTES was tried but could not be completed Open
View article: Efficacy and safety of switching to bilastine, an H1-antihistamine, in patients with refractory chronic spontaneous urticaria (H1-SWITCH): a multicenter, open-label, randomized, parallel-group comparative study
Efficacy and safety of switching to bilastine, an H1-antihistamine, in patients with refractory chronic spontaneous urticaria (H1-SWITCH): a multicenter, open-label, randomized, parallel-group comparative study Open
Background For treating patients with refractory chronic spontaneous urticaria (CSU) resistant to standard doses of 2 nd generation H1-antihistamines (H1AH) the International and Japanese guidelines recommend increasing H1AH dose. The latt…
View article: Ionic Components of Particulate Matter 2.5 May Influence Daily Prevalence of Skin Symptom Exacerbations in Allergy Sufferers
Ionic Components of Particulate Matter 2.5 May Influence Daily Prevalence of Skin Symptom Exacerbations in Allergy Sufferers Open
(1) Background: To date, little research has epidemiologically examined whether the concentration of particulate matter (PM) 2.5 and its ionic components is related to the prevalence of skin symptom exacerbations. Therefore, this study aim…
View article: Effective and safe provocation test for wheat-dependent exercise-induced anaphylaxis (WDEIA) in adults results of testing on 33 cases
Effective and safe provocation test for wheat-dependent exercise-induced anaphylaxis (WDEIA) in adults results of testing on 33 cases Open
Background: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is induced not by the intake of wheat-based food alone, but by the combination of exercise stress and such intake. Provocation tests have been reported to be useful for the d…
View article: Uncovering a Severe Patient Group With Pollen-Related Extrarespiratory Allergic Symptoms: A Year-Long Diary Survey in Japan
Uncovering a Severe Patient Group With Pollen-Related Extrarespiratory Allergic Symptoms: A Year-Long Diary Survey in Japan Open
This 1-year survey identified a small but nonnegligible group of patients with pollen-related extrarespiratory symptoms. More attention should be paid to this patient group considering their impaired activity and work productivity.
View article: Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions
Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions Open
The mutation of the X-linked protocadherin (PCDH) 19 gene in heterozygous females causes epilepsy. However, because of the erosion of X-chromosome inactivation (XCI) in female human pluripotent stem cells, precise disease modeling often le…
View article: Effectiveness of Postnatal Home Visits in Reducing Fatigue Among Mothers with Unplanned Pregnancies
Effectiveness of Postnatal Home Visits in Reducing Fatigue Among Mothers with Unplanned Pregnancies Open
Objective: This study identified the risk factors for fatigue in child-rearing recognizable in early pregnancy and evaluated the effects of postnatal home visits on parenting fatigue. Methods: Data from 348 mothers who delivered live infan…
View article: Nocturnal Scratching and Quality of Sleep in Children with Atopic Dermatitis
Nocturnal Scratching and Quality of Sleep in Children with Atopic Dermatitis Open
Itching due to atopic dermatitis causes sleep disorders in children, but its pathology is unknown. The aim of this study is to investigate nocturnal scratching as an indirect index of itching during sleep and its relationship with depth of…
View article: Nanosheet coating improves stability of human pluripotent stem cell culture on glass substrates
Nanosheet coating improves stability of human pluripotent stem cell culture on glass substrates Open
High-resolution imaging analysis using various types of cells is an essential tool for dissecting cell functions. Generally, obtaining such images requires the cells to be cultured on glass substrates; however, it often results in the unst…
View article: Efficacy and safety of omalizumab in adult patients with wheat-dependent exercise-induced anaphylaxis: Reduction of in vitro basophil activation and allergic reaction to wheat
Efficacy and safety of omalizumab in adult patients with wheat-dependent exercise-induced anaphylaxis: Reduction of in vitro basophil activation and allergic reaction to wheat Open
Long-term omalizumab treatment is safe and effective for adult patients with WDEIA when assessed by basophil activation rate with wheat allergens as well as allergic reactions after lifting of restrictions on wheat intake. However, this is…
View article: De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs
De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs Open
View article: Correction: Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel
Correction: Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel Open
[This corrects the article DOI: 10.18632/oncotarget.25868.].
View article: Efficacy of Dupilumab for Atopic Dermatitis According to Clinical Course and Clinical Findings: A Multicentre Retrospective Study
Efficacy of Dupilumab for Atopic Dermatitis According to Clinical Course and Clinical Findings: A Multicentre Retrospective Study Open
is missing (Short communication)
View article: Genome-wide association study reveals an association between the HLA-DPB1∗02:01:02 allele and wheat-dependent exercise-induced anaphylaxis
Genome-wide association study reveals an association between the HLA-DPB1∗02:01:02 allele and wheat-dependent exercise-induced anaphylaxis Open
View article: Deletion of lncRNA XACT does not change expression dosage of X-linked genes, but affects differentiation potential in hPSCs
Deletion of lncRNA XACT does not change expression dosage of X-linked genes, but affects differentiation potential in hPSCs Open
Female human pluripotent stem cells (hPSCs) regularly show erosion of X chromosome inactivation featured by the loss of the long non-coding (lnc) RNA XIST and the accumulation of lncXACT. Here, we report that a common mechanism for the ini…
View article: Reversible modulation of circadian time with chronophotopharmacology
Reversible modulation of circadian time with chronophotopharmacology Open
View article: Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock
Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock Open
CRY1 and CRY2 proteins are highly conserved components of the circadian clock that controls daily physiological rhythms. Disruption of CRY functions are related to many diseases, including circadian sleep phase disorder. Development of iso…
View article: Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIα activity and circadian rhythms
Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIα activity and circadian rhythms Open
6-Azopurines were evaluated for their reductive stability, and the ability to modulate CKIα activity and cellular circadian rhythms, revealing key challenges for long-term activity modulation utilizing chronophotopharmacology.
View article: xCT inhibitor sulfasalazine depletes paclitaxel‑resistant tumor cells through ferroptosis in uterine serous carcinoma
xCT inhibitor sulfasalazine depletes paclitaxel‑resistant tumor cells through ferroptosis in uterine serous carcinoma Open
Glutathione (GSH) is a primary antioxidant that protects cells against reactive oxygen species (ROS), and high levels of GSH promote cancer cell survival and resistance to chemotherapy. The glutamine transporter xCT is essential for the in…
View article: An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals
An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals Open
View article: Genetic Ablation of lncRNA <i>XACT</i> Does Not Change Expression Dosage of X-Linked 1 Genes But Impacts Differentiation Potential in Female Human Pluripotent Stem Cells
Genetic Ablation of lncRNA <i>XACT</i> Does Not Change Expression Dosage of X-Linked 1 Genes But Impacts Differentiation Potential in Female Human Pluripotent Stem Cells Open
View article: Controlling the Circadian Clock with High Temporal Resolution through Photodosing
Controlling the Circadian Clock with High Temporal Resolution through Photodosing Open
Circadian clocks, biological timekeepers that are present in almost every cell of our body, are complex systems whose disruption is connected to various diseases. Controlling cellular clock function with high temporal resolution in an indu…
View article: Anti-gluten IgE titer is associated with severity of provocation test-evoked symptoms in wheat-dependent exercise-induced anaphylaxis
Anti-gluten IgE titer is associated with severity of provocation test-evoked symptoms in wheat-dependent exercise-induced anaphylaxis Open
View article: Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth
Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth Open
We discovered a new CK2 inhibitor and revealed its mechanism of action, connecting the circadian clock and cancer regulation.
View article: Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel
Metabolomic analysis of uterine serous carcinoma with acquired resistance to paclitaxel Open
We compared metabolic profiles and reactions to paclitaxel in both a wild type USC cell line (USPC-1) and PTX-1, a cell line derived from USPC-1 which acquired paclitaxel resistance, using a capillary electrophoresis CE-MS/MS system.
View article: A Case of Human Fascioliasis with Hypereosinophilia and Migrating Liver Abscess
A Case of Human Fascioliasis with Hypereosinophilia and Migrating Liver Abscess Open
【症 例】54歳,女性.【現病歴】微熱・倦怠感を自覚し近医受診.好酸球増多を認め,精査目的で血液内科紹介となった.初診時微熱以外には,皮疹・リンパ節腫大等認めなかった.白血球11500/?l,好酸球59%と著明な好酸球増多,加えてLDH340U/ml,ALP500U/ml,γ-GTP61U/ml,CRP1.82mg/dlと胆道系酵素異常および炎症反応上昇を認めた.腹部CTでは膿瘍を疑う低吸収域を認めた.2週間後に右季肋部激痛を自覚,CTでの病変は右葉後区域から前下区域主体に…
View article: Issue Information
Issue Information Open