Akimasa Seno YOU? Author Swipe

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Genome-wide mapping of arsenic-activated Nrf2 reveals metabolic and epigenetic reprogramming in induced pluripotent stem cells Open

Akimasa Seno, Zhuoyue Bi, Lisa Polin, Ziqi Liu, Yiran Qiu , et al. · 2025

Genomic and epigenetic characterization of the arsenic-induced oncogenic microRNA-21 Open

Haoyan Ji, Zhuoyue Bi, Aashna S. Pawar, Akimasa Seno, Bandar Almutairy , et al. · 2024

As one of the first identified oncogenic microRNAs, the precise details concerning the transcriptional regulation and function of microRNA-21 (miR-21) are still not completely established. The miR-21 gene is situated on chromosome 17q23.2,…

Digging out MDIG from the mess of H3K9me3, OTX2 and MYC signaling in human cancers Open

Ziwei Wang, Chitra Thakur, Akimasa Seno, Fei Chen · 2024

Cancer stem cells as the source of tumor associated myoepithelial cells in the tumor microenvironment developing ductal carcinoma in situ Open

Said M. Afify, Ghmkin Hassan, Maram H. Zahra, Hend M. Nawara, Hagar A. Abu Quora , et al. · 2023

GSK-3α/β and MEK inhibitors assist the microenvironment of tumor initiation Open

Ghmkin Hassan, Said M. Afify, Maram H. Zahra, Hend M. Nawara, Kazuki Kumon , et al. · 2023

Induced pluripotent stem cells (iPSCs) are useful tools for modeling diseases and developing personalized medicine. We have been developing cancer stem cells (CSCs) from iPSCs with conditioned medium (CM) of cancer-derived cells as the mim…

Genomic and Epigenetic Characterization of the Arsenic-Induced Oncogenic Microrna-21 Open

Haoyan Ji, Zhuoyue Bi, Aashna S. Pawar, Akimasa Seno, Yao Fu , et al. · 2023

Cancer stem cells induced by chronic stimulation with prostaglandin E2 exhibited constitutively activated PI3K axis Open

Hideki Minematsu, Said M. Afify, Yuki Sugihara, Ghmkin Hassan, Maram H. Zahra , et al. · 2022

Deletion of mdig enhances H3K36me3 and metastatic potential of the triple negative breast cancer cells Open

Chitra Thakur, Yiran Qiu, Qian Zhang, Nicholas J. Carruthers, Miaomiao Yu , et al. · 2022

A comparative study of metastatic potentials of three different cancer stem cell models Open

Hager Mansour, Said M. Afify, Ghmkin Hassan, Hagar A. Abu Quora, Hend M. Nawara , et al. · 2022

Cancer-inducing niche: the force of chronic inflammation Open

Said M. Afify, Ghmkin Hassan, Akimasa Seno, Masaharu Seno · 2022

The significance of ErbB2/3 in the conversion of induced pluripotent stem cells into cancer stem cells Open

Ghmkin Hassan, Maram H. Zahra, Akimasa Seno, Masaharu Seno · 2022

Cancer stem cells (CSCs) are suggested to be responsible for drug resistance and aggressive phenotypes of tumors. Mechanisms of CSC induction are still under investigation. Our lab has established a novel method to generate CSCs from iPSCs…

Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open

Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra , et al. · 2022

Background Cancer stem cells (CSCs) are generated under irregular microenvironment in vivo, of which mimic is quite difficult due to the lack of enough information of the factors responsible for cancer initiation. Here, we demonstrated tha…

Additional file 3 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open

Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra , et al. · 2022

Additional file 3: Supplementary Table 3

Additional file 1 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open

Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra , et al. · 2022

Additional file 1: Supplementary Table 1

Additional file 2 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open

Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra , et al. · 2022

Additional file 2: Supplementary Table 2

Additional file 4 of Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways Open

Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra , et al. · 2022

Additional file 4: Supplementary Table 5

New Discoveries and Ambiguities of Nrf2 and ATF3 Signaling in Environmental Arsenic-Induced Carcinogenesis Open

Zhuoyue Bi, Yao Fu, Priya Wadgaonkar, Yiran Qiu, Bandar Almutairy , et al. · 2021

Environment exposure to arsenic had been linked to increased incidents of human cancers. In cellular and animal experimental systems, arsenic has been shown to be highly capable of activating several signaling pathways that play critical r…

Differentiation of cancer stem cells into erythroblasts in the presence of CoCl2 Open

Kazuki Kumon, Said M. Afify, Ghmkin Hassan, Shunsuke Ueno, Sadia Monzur , et al. · 2021

Metabolomic dynamics of the arsenic-transformed bronchial epithelial cells and the derived cancer stem-like cells Open

Yao Fu, Zhuoyue Bi, Lingzhi Li, Priya Wadgaonkar, Yiran Qiu , et al. · 2021

Accumulating evidence indicates a carcinogenic role of environmental arsenic exposure, but mechanisms on how arsenic fosters malignant transformation of the normal cells are not fully established. By applying untargeted global metabolomics…

Paclitaxel-Based Chemotherapy Targeting Cancer Stem Cells from Mono- to Combination Therapy Open

Hend M. Nawara, Said M. Afify, Ghmkin Hassan, Maram H. Zahra, Akimasa Seno , et al. · 2021

Paclitaxel (PTX) is a chemotherapeutical agent commonly used to treat several kinds of cancer. PTX is known as a microtubule-targeting agent with a primary molecular mechanism that disrupts the dynamics of microtubules and induces mitotic …

Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells Open

Zhuoyue Bi, Qian Zhang, Yao Fu, Akimasa Seno, Priya Wadgaonkar , et al. · 2021

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens Open

Rikio Yabe, Soo-Hyun Chung, Masanori A. Murayama, Sachiko Kubo, Kenji Shimizu , et al. · 2021

Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells. Open

Hagar A. Abu Quora, Maram H. Zahra, Samah El‐Ghlban, Neha Nair, Said M. Afify , et al. · 2021

Breast cancer is the first common cause of cancer-related death in women worldwide. Since the malignancy and aggressiveness of breast cancer have been correlated with the presence of breast cancer stem cells, the establishment of a disease…

Cancer Stem Cell Microenvironment Models with Biomaterial Scaffolds In Vitro Open

Ghmkin Hassan, Said M. Afify, Shiro Kitano, Akimasa Seno, Hiroko Ishii , et al. · 2020

Defined by its potential for self-renewal, differentiation and tumorigenicity, cancer stem cells (CSCs) are considered responsible for drug resistance and relapse. To understand the behavior of CSC, the effects of the microenvironment in e…

Metastasis Model of Cancer Stem Cell-Derived Tumors Open

Hager Mansour, Ghmkin Hassan, Said M. Afify, Ting Yan, Akimasa Seno , et al. · 2020

Metastasis includes the dissemination of cancer cells from a malignant tumor and seed in distant sites inside the body forming secondary tumors. Metastatic cells from the primary tumor can move even before the cancer is detected. Therefore…

Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment Open

Juan Du, Yanning Xu, Saki Sasada, Aung Ko Ko Oo, Ghmkin Hassan , et al. · 2020

Cancer stem cells (CSCs) are a class of cancer cells characterized by self-renewal, differentiation and tumorigenic potential. We previously established a model of CSCs by culturing mouse induced pluripotent stem cells (miPSCs) for four we…

Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells Open

Hend Nawara, Said M. Afify, Ghmkin Hassan, Maram H. Zahra, Marwa N. Atallah , et al. · 2020

“Combination therapy”, which is a treatment modality combining two or more therapeutic agents, is considered a cornerstone of cancer therapy. The combination of anticancer drugs, of which functions are different from the other, enhances th…

Revisiting Cancer Stem Cells as the Origin of Cancer-Associated Cells in the Tumor Microenvironment: A Hypothetical View from the Potential of iPSCs Open

Amira Osman, Said M. Afify, Ghmkin Hassan, Xiaoying Fu, Akimasa Seno , et al. · 2020

The tumor microenvironment (TME) has an essential role in tumor initiation and development. Tumor cells are considered to actively create their microenvironment during tumorigenesis and tumor development. The TME contains multiple types of…

A novel model of liver cancer stem cells developed from induced pluripotent stem cells Open

Said M. Afify, Anna Sanchez Calle, Ghmkin Hassan, Kazuki Kumon, Hend M. Nawara , et al. · 2020

Upregulated CCL20 and CCR6 in Cancer Stem Cells Converted from Mouse iPS Cells Open

Juan Du, Akimasa Seno, Saki Sasada, Yanning Xu, Aung Ko Ko Oo , et al. · 2020

Background: Cancer stem cells (CSCs) as a class of malignant cancer cells play an important role in tumor progression. Previous studies by our group have demonstrated the establishment of the model of CSCs converting mouse iPS cells (miPSC…

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