Akimichi Shibata
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View article: Influenza vaccination in Japanese children, 2024/25: Effectiveness of inactivated vaccine and limited use of newly introduced live-attenuated vaccine
Influenza vaccination in Japanese children, 2024/25: Effectiveness of inactivated vaccine and limited use of newly introduced live-attenuated vaccine Open
This study evaluated influenza vaccine effectiveness (VE) among children in Japan during the 2024/25 season, when A(H1N1)pdm09 predominated and live-attenuated influenza vaccine (LAIV) was introduced for the first time. Using a test-negati…
View article: A case of group B streptococcal bacteremia presenting with lumbar cellulitis in a 52-day-old infant
A case of group B streptococcal bacteremia presenting with lumbar cellulitis in a 52-day-old infant Open
Introduction: Group B Streptococcus (GBS) is a leading cause of invasive infections in infants under 3 months of age. While late-onset GBS disease (LOD) typically presents as bacteremia or meningitis, focal skin infections such as cellulit…
View article: A Case of Group B Streptococcal Bacteremia Presenting with Lumbar Cellulitis in a 52-Day-Old Infant
A Case of Group B Streptococcal Bacteremia Presenting with Lumbar Cellulitis in a 52-Day-Old Infant Open
View article: Effectiveness of inactivated influenza vaccine in children during the 2023/24 season: The first season after relaxation of intensive COVID-19 measures
Effectiveness of inactivated influenza vaccine in children during the 2023/24 season: The first season after relaxation of intensive COVID-19 measures Open
This is the first study to demonstrate influenza vaccine effectiveness in children after the relaxation of strict COVID-19 measures in Japan (2023/2024). We recommend the current inactivated vaccine for preventing both influenza A and B in…
View article: Age-Stratified Seroprevalence of SARS-CoV-2 Antibodies before and during the Vaccination Era, Japan, February 2020–March 2022
Age-Stratified Seroprevalence of SARS-CoV-2 Antibodies before and during the Vaccination Era, Japan, February 2020–March 2022 Open
Japan has reported a relatively small number of COVID-19 cases. Because not all infected persons receive diagnostic tests for COVID-19, the reported number must be lower than the actual number of infections. We assessed SARS-CoV-2 seroprev…
View article: Age-stratified seroprevalence of antibodies against SARS-CoV-2 in the pre- and post-vaccination era, February 2020–March 2022, Japan
Age-stratified seroprevalence of antibodies against SARS-CoV-2 in the pre- and post-vaccination era, February 2020–March 2022, Japan Open
Japan has reported a small number of COVID-19 cases relative to other countries. Because not all infected people receive diagnostic tests for COVID-19, the reported number of COVID-19 cases must be lower than the actual number of infection…
View article: Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season
Influenza vaccine effectiveness against influenza A in children based on the results of various rapid influenza tests in the 2018/19 season Open
During influenza epidemics, Japanese clinicians routinely conduct rapid influenza diagnostic tests (RIDTs) in patients with influenza-like illness, and patients with positive test results are treated with anti-influenza drugs within 48 h a…
View article: Fanconi syndrome secondary to deferasirox with severe and prolonged urinary potassium loss in a β-thalassemia major patient
Fanconi syndrome secondary to deferasirox with severe and prolonged urinary potassium loss in a β-thalassemia major patient Open
重症 β サラセミアの16 歳女性.輸血後鉄過剰症に対し 13 歳時より経口鉄キレート剤 deferasirox (Def) を開始した.5 か月後に低K,低P,低尿酸血症を認め,P を補充した.14 歳時に同種末梢血幹細胞移植を行った.16 歳時に胃腸炎症状に伴い著明な低K,低P,低尿酸血症,腎性糖尿,低分子蛋白尿を認めDef による Fanconi 症候群と診断し,P に加えてK の補充を開始した.Def を減量したが,4 か月後に代謝性アシドーシスも出現し,Def を…
View article: A lacZ Reporter Transgenic Mouse Line Revealing the Development of Pulmonary Artery
A lacZ Reporter Transgenic Mouse Line Revealing the Development of Pulmonary Artery Open
Pulmonary vasculature in mice develops through two main mechanisms, namely angiogenesis and vasculogenesis. At embryonic day (E) 9.5, vascular endothelial marker Tie2-driven LacZ expression in whole-mount transgenic lungs showed continuity…
View article: Ca2+ Signal Through Inositol Trisphosphate Receptors for Cardiovascular Development and Pathophysiology of Pulmonary Arterial Hypertension
Ca2+ Signal Through Inositol Trisphosphate Receptors for Cardiovascular Development and Pathophysiology of Pulmonary Arterial Hypertension Open
Inositol triphosphate receptor (IP3R) is an intracellular Ca2+ release channel located on the membrane of the sarco/endoplasmic reticulum (SR/ER), a major intracellular storage site for Ca2+. There are three subtypes of IP3R (IP3R1, 2, and…
View article: Polysplenia Syndrome as a Risk Factor for Early Progression of Pulmonary Hypertension
Polysplenia Syndrome as a Risk Factor for Early Progression of Pulmonary Hypertension Open
Polysplenia syndrome is an independent risk factor for CHD-associated PH. Earlier intervention may be required to adjust the pulmonary blood flow in polysplenia syndrome with CHD to avoid the progression of PH.
View article: Optical Frequency Domain Imaging and Intravascular Ultrasound for Adult-Onset Kawasaki Disease in the Sub-Acute Phase
Optical Frequency Domain Imaging and Intravascular Ultrasound for Adult-Onset Kawasaki Disease in the Sub-Acute Phase Open
View article: Utility of Coronary Computed Tomography Angiography in the Diagnosis and Management of Acute-Phase Adult-Onset Kawasaki Disease
Utility of Coronary Computed Tomography Angiography in the Diagnosis and Management of Acute-Phase Adult-Onset Kawasaki Disease Open
View article: Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation
Biodegradability of poly(lactic-co-glycolic acid) after femtosecond laser irradiation Open
Biodegradation is a key property for biodegradable polymer-based tissue scaffolds because it can provide suitable space for cell growth as well as tailored sustainability depending on their role. Ultrashort pulsed lasers have been widely u…
View article: Pulmonary Arterial Hypertension in Patients with Heterotaxy/Polysplenia Syndrome
Pulmonary Arterial Hypertension in Patients with Heterotaxy/Polysplenia Syndrome Open
Early progressive pulmonary arterial hypertension (PAH) is often observed in patients with heterotaxy/polysplenia especially who have an intracardiac systemic-to-pulmonary shunt. However, its etiology is uncertain and its management is not…
View article: Modification of Cardiac Phenotype in Tbx1 Hypomorphic Mice
Modification of Cardiac Phenotype in Tbx1 Hypomorphic Mice Open
Congenital heart disease is still the leading cause of death within the first year of life. Our lab forces on understanding the morphology of congenital heart disease. Outflow tract anomalies, including abnormal alignment or septation, acc…
View article: A History and Interaction of Outflow Progenitor Cells Implicated in “Takao Syndrome”
A History and Interaction of Outflow Progenitor Cells Implicated in “Takao Syndrome” Open
Progenitor cells, derived from the cardiac neural crest (CNC) and the second heart field (SHF), play key roles in development of the cardiac outflow tract (OFT), and their interaction is essential for establishment of the separate pulmonar…