Akira Sugawara
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View article: Comparative effectiveness of biguanides versus SGLT2 inhibitors on cardiovascular and cerebrovascular events, diabetic nephropathy, retinopathy, neuropathy, and treatment expenditures in patients with type 2 diabetes
Comparative effectiveness of biguanides versus SGLT2 inhibitors on cardiovascular and cerebrovascular events, diabetic nephropathy, retinopathy, neuropathy, and treatment expenditures in patients with type 2 diabetes Open
Background Sodium–glucose cotransporter-2 (SGLT2) inhibitors are increasingly recommended as first-line treatment for type 2 diabetes mellitus (T2DM), but head-to-head data comparing them with metformin, the canonical biguanide, remain spa…
View article: Guidelines for the diagnosis of Graves' disease, hypothyroidism, painless thyroiditis, chronic thyroiditis (Hashimoto's thyroiditis), and subacute thyroiditis (acute phase)
Guidelines for the diagnosis of Graves' disease, hypothyroidism, painless thyroiditis, chronic thyroiditis (Hashimoto's thyroiditis), and subacute thyroiditis (acute phase) Open
View article: The JSH Morning Hypertension Eradication Program Project
The JSH Morning Hypertension Eradication Program Project Open
View article: Development of a Predictive Tool for Maintenance Dialysis Initiation: A Retrospective Cohort Analysis of 589,284 Participants From the Shizuoka Kokuho Database Study
Development of a Predictive Tool for Maintenance Dialysis Initiation: A Retrospective Cohort Analysis of 589,284 Participants From the Shizuoka Kokuho Database Study Open
Our model, leveraging routine health checkup data, accurately identifies persons at elevated risk for future dialysis despite low event rates.
View article: Declaration for the eradication of morning hypertension
Declaration for the eradication of morning hypertension Open
View article: AID–2×RBD27, an auxin-inducible degron-based Rab27 trapper that reversibly inhibits the function of Rab27A in melanocytes
AID–2×RBD27, an auxin-inducible degron-based Rab27 trapper that reversibly inhibits the function of Rab27A in melanocytes Open
Small GTPase Rabs are evolutionarily conserved regulators of intracellular membrane traffic and regulate multiple steps in membrane trafficking. Although various approaches have been used to identify the function(s) of individual Rabs, no …
View article: A CRISPR-based high-throughput screening system identifies bromodomain inhibitors as transcriptional suppressors of CYP11B1
A CRISPR-based high-throughput screening system identifies bromodomain inhibitors as transcriptional suppressors of CYP11B1 Open
CYP11B1 encodes steroid 11β-hydroxylase, the final rate-limiting enzyme for cortisol biosynthesis in the adrenal cortex. Excessive cortisol production is a hallmark of Cushing's disease (CD). While direct enzymatic inhibitors have been exp…
View article: Real-world outcomes and management trends in uncomplicated type B aortic dissection
Real-world outcomes and management trends in uncomplicated type B aortic dissection Open
OBJECTIVES Uncomplicated type B aortic dissection (uTBAD) accounts for a significant proportion of TBAD cases, but large-scale data on their prognosis remain limited. This study aims to evaluate real-world management and outcomes of uTBAD.…
View article: Digital hypertension, implementation hypertension, and internationalization - 3 pillars of Japanese Society of Hypertension 2024–2026 advancing hypertension science from Japan to the world in the information network era
Digital hypertension, implementation hypertension, and internationalization - 3 pillars of Japanese Society of Hypertension 2024–2026 advancing hypertension science from Japan to the world in the information network era Open
View article: Comparing the effects of biguanides and dipeptidyl peptidase-4 inhibitors on cardio-cerebrovascular outcomes, nephropathy, retinopathy, neuropathy, and treatment costs in diabetic patients
Comparing the effects of biguanides and dipeptidyl peptidase-4 inhibitors on cardio-cerebrovascular outcomes, nephropathy, retinopathy, neuropathy, and treatment costs in diabetic patients Open
Background Western guidelines often recommend biguanides as the first-line treatment for diabetes. However, dipeptidyl peptidase-4 (DPP-4) inhibitors, alongside biguanides, are increasingly used as the first-line therapy for type 2 diabete…
View article: Leukotriene antagonists reduce epileptic seizures‐related hospitalization in older adult populations with allergic rhinitis or asthma: A population‐based cohort study using the Shizuoka Kokuho database: The Shizuoka study
Leukotriene antagonists reduce epileptic seizures‐related hospitalization in older adult populations with allergic rhinitis or asthma: A population‐based cohort study using the Shizuoka Kokuho database: The Shizuoka study Open
Objective Managing the risk of epileptic seizures in older adults is increasingly important as the population ages. Leukotriene receptor antagonists (LTRAs) are commonly used to treat asthma or allergic rhinitis. Preclinical studies sugges…
View article: Postnatal expression of <scp>CD38</scp> in astrocytes regulates synapse formation and adult social memory
Postnatal expression of <span>CD38</span> in astrocytes regulates synapse formation and adult social memory Open
Social behavior is essential for health, survival, and reproduction of animals; however, the role of astrocytes in social behavior remains largely unknown. The transmembrane protein CD38, which acts both as a receptor and ADP‐ribosyl cycla…
View article: Primary aldosteronism and obstructive sleep apnea: the strong ties between them
Primary aldosteronism and obstructive sleep apnea: the strong ties between them Open
View article: A case of malignant hypertension as a presentation of atypical hemolytic uremic syndrome
A case of malignant hypertension as a presentation of atypical hemolytic uremic syndrome Open
mHTN is a common presentation of aHUS. In cases of mHTN, abnormalities in complement-related genes may be involved in the development of the disease.
View article: Factors associated with incidence of acute kidney injury: a Japanese regional population-based cohort study, the Shizuoka study
Factors associated with incidence of acute kidney injury: a Japanese regional population-based cohort study, the Shizuoka study Open
View article: LBODP052 A Novel Hnf4α Corepressor Irf2bp2: Its Role In The Gluconeogenic Gene Regulation Via Biochemically Labile Interaction
LBODP052 A Novel Hnf4α Corepressor Irf2bp2: Its Role In The Gluconeogenic Gene Regulation Via Biochemically Labile Interaction Open
Hepatocyte nuclear factor 4α (HNF4α) has an essential role in controlling the expression of variety of genes involved in key metabolic pathways including gluconeogenesis in the liver. Though mechanistic and physiological significance of pr…
View article: LBODP050 Examination Of The Effectiveness Of Diabetic Nephropathy Treatment Targeting Chrebp Activity
LBODP050 Examination Of The Effectiveness Of Diabetic Nephropathy Treatment Targeting Chrebp Activity Open
Diabetic nephropathy (DN) is the main cause of chronic kidney disease (CKD) and is characterized by elevated urinary albumin to creatinine ratio (UACR) and serum creatinine, and decreased glomerular filtration rate. Anti hypertensive agent…
View article: LBODP025 A Novel Drug Discovery For Primary Aldosteronism Targeting Aldosterone Synthase (cyp11b2) And Kcnj5 Mutant
LBODP025 A Novel Drug Discovery For Primary Aldosteronism Targeting Aldosterone Synthase (cyp11b2) And Kcnj5 Mutant Open
Primary aldosteronism (PA) is a common cause of secondary hypertension. PA induces damage to cardiovascular and renal blood vessels. Therefore, PA is regarded as a problem because it increases the risk of stroke, cardiomyopathy, kidney dis…
View article: YM750, an ACAT Inhibitor, Acts on Adrenocortical Cells to Inhibit Aldosterone Secretion Due to Depolarization
YM750, an ACAT Inhibitor, Acts on Adrenocortical Cells to Inhibit Aldosterone Secretion Due to Depolarization Open
Primary aldosteronism (PA) is considered the most common form of secondary hypertension, which is associated with excessive aldosterone secretion in the adrenal cortex. The cause of excessive aldosterone secretion is the induction of aldos…
View article: Cover
Cover Open
The cover image is based on the Original Article A novel 8.57‐kb deletion of the upstream region of PRKAR1A in a family with Carney complex by Shin Ito et al., https://doi.org/10.1002/mgg3.1884. [Image: see text]
View article: A novel 8.57‐kb deletion of the upstream region of <i>PRKAR1A</i> in a family with Carney complex
A novel 8.57‐kb deletion of the upstream region of <i>PRKAR1A</i> in a family with Carney complex Open
Carney complex (CNC) is a rare hereditary syndrome that involves endocrine dysfunction and the development of various types of tumors. Chromosome 2p16 and PRKAR1A on chromosome 17 are known susceptibility loci for CNC. Here we report a mot…
View article: Brachial artery transposition versus catheters as tertiary vascular access for maintenance hemodialysis: a single-center retrospective study
Brachial artery transposition versus catheters as tertiary vascular access for maintenance hemodialysis: a single-center retrospective study Open
View article: The physiological and pathophysiological roles of carbohydrate response element binding protein in the kidney
The physiological and pathophysiological roles of carbohydrate response element binding protein in the kidney Open
Glucose is not only the energy fuel for most cells, but also the signaling molecule which affects gene expression via carbohydrate response element binding protein (ChREBP), a Mondo family transcription factor. In response to high glucose …
View article: Astroglial CD38 regulates social memory and synapse formation through SPARCL1 in the medial prefrontal cortex
Astroglial CD38 regulates social memory and synapse formation through SPARCL1 in the medial prefrontal cortex Open
Social behavior is essential for the health, survival and reproduction of animals, yet the role of astrocytes in social behavior is largely unknown. CD38 is critical for social behaviors by regulating oxytocin release from hypothalamic neu…
View article: Ultrastructural observation of filtration membrane in cell‐free and concentrated ascites reinfusion therapy for malignant ascites
Ultrastructural observation of filtration membrane in cell‐free and concentrated ascites reinfusion therapy for malignant ascites Open
Introduction Cell‐free and concentrated ascites reinfusion therapy (CART) is used for the treatment of diuretic‐resistant ascites. An increase in circuit pressure and clogging of the filtration membrane often occur in CART for malignant as…
View article: Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1
Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1 Open
The androgen receptor (AR) plays an essential role in the development of prostate cancer, and androgen-deprivation therapy is used as a first-line treatment for prostate cancer. However, under androgen-deprivation therapy, castration-resis…
View article: Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway
Molecular Mechanisms of Functional Adrenocortical Adenoma and Carcinoma: Genetic Characterization and Intracellular Signaling Pathway Open
The adrenal cortex produces steroid hormones as adrenocortical hormones in the body, secreting mineralocorticoids, glucocorticoids, and adrenal androgens, which are all considered essential for life. Adrenocortical tumors harbor divergent …
View article: Brachial Artery Transposition Versus Catheters as Tertiary Vascular Access for Maintenance Hemodialysis: A Single-Center Retrospective Study
Brachial Artery Transposition Versus Catheters as Tertiary Vascular Access for Maintenance Hemodialysis: A Single-Center Retrospective Study Open
Background: Some hemodialysis patients are not suitable for creation of an arteriovenous fistula (AVF) or arteriovenous graft (AVG). They can receive a tunneled cuffed central venous catheter (tcCVC), but this carries risks of infection an…
View article: The usefulness of angiotensin-(1-7) and des-Arg9-bradykinin as novel biomarkers for metabolic syndrome
The usefulness of angiotensin-(1-7) and des-Arg9-bradykinin as novel biomarkers for metabolic syndrome Open
View article: Heparin-induced thrombocytopenia among incident hemodialysis patients anticoagulated with low molecular weight heparin: A single-center retrospective study
Heparin-induced thrombocytopenia among incident hemodialysis patients anticoagulated with low molecular weight heparin: A single-center retrospective study Open