Akiteru Goto
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View article: Molecular characterization of chronic inflammatory diseases of the urinary bladder based on next-generation RNA sequencing and digital image analysis
Molecular characterization of chronic inflammatory diseases of the urinary bladder based on next-generation RNA sequencing and digital image analysis Open
This study aimed to elucidate distinct cellular and immunological characteristics associated with chronic inflammatory conditions of the urinary bladder, including Hunner-type interstitial cystitis (HIC), bacillus Calmette-Guérin (BCG)-rel…
View article: Pathological Angiogenesis Precedes the Onset of Aortic Dissection
Pathological Angiogenesis Precedes the Onset of Aortic Dissection Open
Summary Aortic dissection (AD) is a severe, life-threatening disease that occurs abruptly 1 . Although remodeling and inherent vulnerability of the aortic media, as observed in heritable connective tissue disorders such as Marfan syndrome,…
View article: AKT: A Central Node in Complex Signaling Cascades
AKT: A Central Node in Complex Signaling Cascades Open
Akt (v-akt murine thymoma virus oncogene homologue) is a well-known serine-threonine kinase that functions as a central node in various important signal cascades involved in cellular maintenance. Akt has also been implicated in oncogenic m…
View article: Prognostic significance of cancer-associated fibroblasts and tumor-associated macrophages in the tongue squamous cell carcinoma and their correlation with tumor budding
Prognostic significance of cancer-associated fibroblasts and tumor-associated macrophages in the tongue squamous cell carcinoma and their correlation with tumor budding Open
These findings indicate that CAFs significantly influence the invasive characteristics of TSCC and are correlated with tumor budding and a poor prognosis. These results underscore the potential of targeting CAFs as a therapeutic strategy f…
View article: A Multigene Mutation Signature for Prognostic Stratification in Tongue Oral Squamous Cell Carcinoma
A Multigene Mutation Signature for Prognostic Stratification in Tongue Oral Squamous Cell Carcinoma Open
View article: <scp>APRIL</scp> / <scp>BAFF</scp> upregulation is associated with clonal B‐cell expansion in Hunner‐type interstitial cystitis
<span>APRIL</span> / <span>BAFF</span> upregulation is associated with clonal B‐cell expansion in Hunner‐type interstitial cystitis Open
Hunner‐type interstitial cystitis (HIC) is a chronic inflammatory disease of the urinary bladder with an unknown etiology. We conducted comprehensive immunogenomic profiling of bladder specimens obtained by biopsy and cystectomy from 37 pa…
View article: Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma
Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma Open
The nature of microRNA (miRNA) dysfunction in carcinogenesis remains controversial because of the complex connection between miRNA structural diversity and biological processes. Here, we found that oncofetal IGF2BP3 regulates the selective…
View article: Prognostic value of CAF marker expression in the intratumoral and marginal areas of soft tissue sarcoma
Prognostic value of CAF marker expression in the intratumoral and marginal areas of soft tissue sarcoma Open
Introduction: The tumor microenvironment of sarcomas has not been studied in detail; in particular, little is known about cancer-associated fibroblasts (CAFs). Sarcoma cells are difficult to distinguish from CAFs, either histomorphological…
View article: Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers
Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers Open
Background Lung adenocarcinoma (LUAD) in never-smokers is a major public health burden, especially among East Asian women. Polygenic risk scores (PRSs) are promising for risk stratification but are primarily developed in European-ancestry …
View article: A case of pancreatic PEComa with prominent inflammatory cell infiltration: the inflammatory subtype is a distinct histologic group of PEComa
A case of pancreatic PEComa with prominent inflammatory cell infiltration: the inflammatory subtype is a distinct histologic group of PEComa Open
Background PEComa is a mesenchymal tumor that can occur in various organs including the uterus and soft tissues. PEComas are composed of perivascular epithelioid cells, and angiomyolipoma (AML), clear cell sugar tumor (CCST), and lymphangi…
View article: Research autopsy programmes in oncology: shared experience from 14 centres across the world
Research autopsy programmes in oncology: shared experience from 14 centres across the world Open
While there is a great clinical need to understand the biology of metastatic cancer in order to treat it more effectively, research is hampered by limited sample availability. Research autopsy programmes can crucially advance the field thr…
View article: Association between NLRP3 Inflammasome and Tumor-Node-Metastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens
Association between NLRP3 Inflammasome and Tumor-Node-Metastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens Open
The pathological role of NLRP3 inflammasome in prostate cancer (PCa) remains unclear. This study aimed to elucidate the expression of its major components in PCa by immunohistochemistry and its clinicopathological significance. An immunohi…
View article: Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses
Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses Open
View article: Exosomes secreted by <scp><i>ST3GAL5</i><sup>high</sup></scp> cancer cells promote peritoneal dissemination by establishing a premetastatic microenvironment
Exosomes secreted by <span><i>ST3GAL5</i><sup>high</sup></span> cancer cells promote peritoneal dissemination by establishing a premetastatic microenvironment Open
Peritoneal dissemination of cancer affects patient survival. The behavior of peritoneal mesothelial cells (PMCs) and immune cells influences the establishment of a microenvironment that promotes cancer cell metastasis in the peritoneum. He…
View article: A Case of Papillary Lung Adenocarcinoma Derived from Malignant Transformation of Papillary Adenoma
A Case of Papillary Lung Adenocarcinoma Derived from Malignant Transformation of Papillary Adenoma Open
背景．肺乳頭腺腫は非常に稀であるが，肺腺癌へ悪性転化する場合がある．今回我々は，肺乳頭腺腫の悪性転化と考えられた乳頭型肺腺癌の1例を経験した．症例．45歳男性．X－8年前にCTで偶発的に右下葉に結節影を認め，外科的生検を検討していたが，通院を自己中断した．X年に右背部痛を主訴に近医を受診し，CTで右下葉結節影が認められたため，精査・加療目的に当科へ紹介された．気管支鏡検査で肺腺癌の疑いと診断を得たため，右下葉切除＋縦隔リンパ節郭清術を施行した．肉眼的所見では，20 mm大の…
View article: CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress
CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress Open
MicroRNAs (miRNAs) play pivotal roles in the tumor microenvironment. Here, we analyzed miRNAs in tumor stromal fibroblasts. Expression of miR-224-3p in cancer-associated fibroblasts (CAF) from scirrhous gastric cancer patients was lower th…
View article: Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population Open
View article: Identification of Uromodulin Deposition in the Stroma of Perinephric Fibromyxoid Nephrogenic Adenoma by Mass Spectrometry
Identification of Uromodulin Deposition in the Stroma of Perinephric Fibromyxoid Nephrogenic Adenoma by Mass Spectrometry Open
Background Nephrogenic adenoma (NA) is an epithelial lesion that usually occurs in the mucosa of the urinary tract. Rare cases of deep infiltrative or perinephric lesions have also been reported. Recently, NA with characteristic fibromyxoi…
View article: Supplementary Figure 7 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 7 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Models of PMC-mediated gastric cancer progression.
View article: Supplementary Figure 5 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 5 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Effects of ALDH inhibition on cancer cells, PMCs and CAFs.
View article: Supplementary Figure 4 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 4 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Wnt3a-mediated PMC infiltration was blocked byDKK1183-266.
View article: Supplementary Figure 7 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 7 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Models of PMC-mediated gastric cancer progression.
View article: Supplementary Figure 2 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 2 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Cancer cell-released CD63-containing EVs are diffused in the stomach.
View article: Supplementary Figure 3 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 3 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Wnt3a attracts PMC migration.
View article: Supplementary Figure 5 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 5 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Effects of ALDH inhibition on cancer cells, PMCs and CAFs.
View article: Supplementary Materials and Methods from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Materials and Methods from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Materials and Methods not included in the text
View article: Supplementary Figure 6 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 6 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Peritoneal metastasis of human gastric cancer, and effects of ALDH inhibition on tumor growth.
View article: Supplementary Figure 4 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 4 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Wnt3a-mediated PMC infiltration was blocked byDKK1183-266.
View article: Supplementary Figure 6 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 6 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Peritoneal metastasis of human gastric cancer, and effects of ALDH inhibition on tumor growth.
View article: Supplementary Figure 2 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion
Supplementary Figure 2 from Mesothelial Cells Create a Novel Tissue Niche That Facilitates Gastric Cancer Invasion Open
Cancer cell-released CD63-containing EVs are diffused in the stomach.