Akshat D. Modi
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View article: AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury
AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury Open
Following traumatic cervical spinal cord injury (SCI), injury-induced functional changes within the perilesional forelimb circuits are an important cause of neurological dysfunction. K+/Cl- cotransporter 2 (KCC2) is a…
View article: Nanogel-mediated therapeutic delivery across blood-cerebrospinal fluid and blood-spinal cord barriers
Nanogel-mediated therapeutic delivery across blood-cerebrospinal fluid and blood-spinal cord barriers Open
Nanogels are emerging as promising nanocarriers for delivering therapeutic agents to treat central nervous system (CNS) disorders. Traditional therapeutic approaches for CNS disorders are often hindered by the inability to cross the blood-…
View article: Translational Relevance of Secondary Intracellular Signaling Cascades Following Traumatic Spinal Cord Injury
Translational Relevance of Secondary Intracellular Signaling Cascades Following Traumatic Spinal Cord Injury Open
Traumatic spinal cord injury (SCI) is a life-threatening and life-altering condition that results in debilitating sensorimotor and autonomic impairments. Despite significant advances in the clinical management of traumatic SCI, many patien…
View article: Insights from clinical trials: New evidence supports surgical interventions over drug therapies for atrial fibrillation
Insights from clinical trials: New evidence supports surgical interventions over drug therapies for atrial fibrillation Open
Atrial fibrillation (AF) is one of the world’s most prevalent cardiac arrhythmias. It poses a heavy burden on patients, physicians and the global healthcare system as it is one of the top leading causes of cardiovascular death. Researchers…
View article: Epitranscriptomics and cervical cancer: the emerging role of m<sup>6</sup>A, m<sup>5</sup>C and m<sup>1</sup>A RNA modifications
Epitranscriptomics and cervical cancer: the emerging role of m<sup>6</sup>A, m<sup>5</sup>C and m<sup>1</sup>A RNA modifications Open
Cervical cancer (CC), one of the most prevalent and detrimental gynaecologic cancers, evolves through genetic and epigenetic alterations resulting in the promotion of oncogenic activity and dysfunction of tumour-suppressing mechanisms. Des…
View article: A perspective on next generation nanomedicine: Nanogels for therapeutic delivery in biomedical research
A perspective on next generation nanomedicine: Nanogels for therapeutic delivery in biomedical research Open
View article: Polysaccharide-based nanogels and ocular drug delivery: The emerging nanocarrier for crossing blood retinal barrier
Polysaccharide-based nanogels and ocular drug delivery: The emerging nanocarrier for crossing blood retinal barrier Open
The present era demands the development of drug delivery systems that can target therapeutic agents to the site of action with minimal concentration, thereby avoiding unwanted side effects. One of the major obstacles to achieving this obje…
View article: Comparing monopharmacotherapy of antiarrhythmic and anticoagulant drugs with other drugs for atrial fibrillation: A complete review of clinical trials
Comparing monopharmacotherapy of antiarrhythmic and anticoagulant drugs with other drugs for atrial fibrillation: A complete review of clinical trials Open
Atrial fibrillation (AF) is a life-changing and life-threatening cardiac electropathological condition, especially in patients with prior history of cardiovascular diseases. This multifaceted condition is one of the top 5 leading causes of…