Akshayata Naidu
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View article: Monosodium urate crystals exposure is associated with limited transcriptional changes in primary human PBMCs
Monosodium urate crystals exposure is associated with limited transcriptional changes in primary human PBMCs Open
Introduction Monosodium urate (MSU) crystals are the primary cause of gout, however the knowledge on MSU crystals exposure and inflammatory changes found in immune cells is diverse, with reports ranging from very limited inflammatory effec…
View article: Mapping integral cell-type-specific interferon-induced gene regulatory networks (GRNs) involved in systemic lupus erythematosus using systems and computational analysis
Mapping integral cell-type-specific interferon-induced gene regulatory networks (GRNs) involved in systemic lupus erythematosus using systems and computational analysis Open
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder characterized by the production of autoantibodies, resulting in inflammation and organ damage. Although extensive research has been conducted on SLE pathogenesis, a compr…
View article: Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children
Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children Open
RTS,S/AS01(E), the first approved malaria vaccine, demonstrated moderate efficacy during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) responses following the primary 3-dose immunization and now report …
View article: The effect of the RTS,S/AS01E vaccine booster dose on cell-mediated immune responses in African infants and children
The effect of the RTS,S/AS01E vaccine booster dose on cell-mediated immune responses in African infants and children Open
RTS,S/AS01E, the first approved malaria vaccine, demonstrated moderate efficacy during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) responses following the primary 3-dose immunizations and now report r…
View article: Systems and computational analysis of gene expression datasets reveals GRB-2 suppression as an acute immunomodulatory response against enteric infections in endemic settings
Systems and computational analysis of gene expression datasets reveals GRB-2 suppression as an acute immunomodulatory response against enteric infections in endemic settings Open
Introduction Enteric infections are a major cause of under-5 (age) mortality in low/middle-income countries. Although vaccines against these infections have already been licensed, unwavering efforts are required to boost suboptimalefficacy…
View article: Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease
Prospects of Novel and Repurposed Immunomodulatory Drugs against Acute Respiratory Distress Syndrome (ARDS) Associated with COVID-19 Disease Open
Acute respiratory distress syndrome (ARDS) is intricately linked with SARS-CoV-2-associated disease severity and mortality, especially in patients with co-morbidities. Lung tissue injury caused as a consequence of ARDS leads to fluid build…
View article: Advances in computational frameworks in the fight against TB: The way forward
Advances in computational frameworks in the fight against TB: The way forward Open
Around 1.6 million people lost their life to Tuberculosis in 2021 according to WHO estimates. Although an intensive treatment plan exists against the causal agent, Mycobacterium Tuberculosis , evolution of multi-drug resistant strains of t…
View article: The formal ability of countries to deliver high-quality vaccination services: Introducing the Country Vaccination Score (CVS)
The formal ability of countries to deliver high-quality vaccination services: Introducing the Country Vaccination Score (CVS) Open
Despite the huge benefits of vaccination, vaccine uptake around the globe is surprisingly suboptimal in most places; explanations include vaccine hesitancy and increasingly well-organized anti-vaccine groups. In addition, WHO identified st…