Alaa Madi
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View article: Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma
Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma Open
After recognizing its ligand lipopolysaccharide, Toll-like receptor 4 (TLR4) recruits adaptor proteins to the cell membrane, thereby initiating downstream signaling and triggering inflammation. Whether this recruitment of adaptor proteins …
View article: The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate
The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate Open
The malate shuttle is traditionally understood to maintain NAD + /NADH balance between the cytosol and mitochondria. Whether the malate shuttle has additional functions is unclear. Here we show that chronic viral infections induce CD8 + T …
View article: Regulatory T cell‐derived interleukin‐15 promotes the diversity of immunological memory
Regulatory T cell‐derived interleukin‐15 promotes the diversity of immunological memory Open
While the immunosuppressive function of regulatory T (Treg) cells has been extensively studied, their immune‐supportive roles have been less well investigated. Using a lymphocytic choriomeningitis virus (LCMV) Armstrong infection mouse mod…
View article: <scp>CD8</scp> agonism functionally activates memory T cells and enhances antitumor immunity
<span>CD8</span> agonism functionally activates memory T cells and enhances antitumor immunity Open
Memory CD8 + T cells mature after antigen clearance and ultimately express CD8 protein at levels higher than those detected in effector CD8 + T cells. However, it is not clear whether engagement of CD8 in the absence of antigenic stimulati…
View article: Skeletal muscle antagonizes antiviral CD8 <sup>+</sup> T cell exhaustion
Skeletal muscle antagonizes antiviral CD8 <sup>+</sup> T cell exhaustion Open
Skeletal muscle shelters a group of T cells from systemic and chronic inflammation to protect T cell proliferative potential.
View article: T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development
T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident Memory T Cell Development Open
View article: Regulation of immune cell metabolism by cancer cell oncogenic mutations
Regulation of immune cell metabolism by cancer cell oncogenic mutations Open
In noncancerous tissues, neighboring cells coexist in metabolic harmony. This metabolic harmony is disrupted in cancerous tissues, often accompanied by genetic mutations. Tumor cells fundamentally change the metabolite profiles in the tumo…
View article: Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness Open