Aladdin Kanbour
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View article: 627 Soluble immune modulatory cytokines and immune checkpoint molecules as predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
627 Soluble immune modulatory cytokines and immune checkpoint molecules as predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients Open
View article: Prevalence of Molecular Mutations in Non–Small Cell Lung Cancer and Current Treatment Approaches in the MENA Region: Systematic Review and Expert Opinion
Prevalence of Molecular Mutations in Non–Small Cell Lung Cancer and Current Treatment Approaches in the MENA Region: Systematic Review and Expert Opinion Open
Over the past decade, the discovery of immunotherapy and targeted therapy has set new standards for the management of advanced non–small cell lung cancer (NSCLC). This study aims to investigate the prevalence of ALK, EGFR, KRAS, ROS1, MET,…
View article: Uro‐genital oncology synergy: Accelerating treatment with multidisciplinary joint counseling clinic
Uro‐genital oncology synergy: Accelerating treatment with multidisciplinary joint counseling clinic Open
Introduction Uro‐genital oncology patients often face complex treatment decisions requiring multiple consultations, which can delay treatment initiation and lead to fragmented care. Traditional approaches are particularly challenging for p…
View article: Understanding and Overcoming Barriers to Admissions and Timely Discharges in a Cancer Hospital: A Case Study of National Centre for Cancer Care and Research, Doha, Qatar
Understanding and Overcoming Barriers to Admissions and Timely Discharges in a Cancer Hospital: A Case Study of National Centre for Cancer Care and Research, Doha, Qatar Open
Background Improving access to healthcare is crucial for patient experience, clinical safety, timeliness of care, and reducing staff pressure. The National Centre for Cancer Care and Research (NCCCR), the primary cancer center in Qatar, co…
View article: Real-World Data Presenting the Descriptive Analysis of the Use of Tyrosine Kinase Inhibitors (TKIs) Among Metastatic Non–Small-Cell Lung Cancer (mNSCLC) Patients in Qatar: A Nationwide Retrospective Cohort Study
Real-World Data Presenting the Descriptive Analysis of the Use of Tyrosine Kinase Inhibitors (TKIs) Among Metastatic Non–Small-Cell Lung Cancer (mNSCLC) Patients in Qatar: A Nationwide Retrospective Cohort Study Open
Background: There has been significant improvement in treating metastatic non–small-cell lung cancer (mNSCLC) over the past 2 decades. The aim of this study is to describe the use of tyrosine kinase inhibitors (TKIs) in Qatar. This study f…
View article: Serum immune mediators as novel predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients with high tissue-PD-L1 expression
Serum immune mediators as novel predictors of response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients with high tissue-PD-L1 expression Open
Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related morbidity and mortality worldwide. Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treat…
View article: Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients Open
Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% of the patients still fail to respond to I…
View article: Leptomeningeal Metastatic L858R EGFR-mutant Lung Cancer: Prompt Response to Osimertinib in the Absence of T790M-mutation and Effective Subsequent Pulsed Erlotinib
Leptomeningeal Metastatic L858R EGFR-mutant Lung Cancer: Prompt Response to Osimertinib in the Absence of T790M-mutation and Effective Subsequent Pulsed Erlotinib Open
Leptomeningeal carcinomatosis (LMC) is a known sequel of metastatic lung cancer and its treatment is challenging. Nevertheless, treatment options for LMC due to metastatic epidermal growth factor receptor-mutant (EGFR-mutant) lung a…
View article: 17 Predictive soluble biomarkers of immune response to checkpoint blockade in non-small cell lung cancer (NSCLC) patients
17 Predictive soluble biomarkers of immune response to checkpoint blockade in non-small cell lung cancer (NSCLC) patients Open
Background There is limited data on the predictive biomarkers of response to immune checkpoint blockade (ICB) treatment of non-small cell lung cancer (NSCLC) patients. The main aim of this prospective study was to understand the utility of…
View article: Imaging Biomarkers in Lung Cancer with<sup>68</sup>Ga-DOTATATE,<sup>18</sup>F-Fluoride, and<sup>18</sup>F-FDG PET/CT Scans and the Theranostics Paradigm
Imaging Biomarkers in Lung Cancer with<sup>68</sup>Ga-DOTATATE,<sup>18</sup>F-Fluoride, and<sup>18</sup>F-FDG PET/CT Scans and the Theranostics Paradigm Open
Lung cancer is the number 1 cause of cancer deaths in the United States. The prognosis is quite grim with the exception of stage 1. When faced with several failed therapeutic regimens and rapid progression of the disease, considering alter…
View article: Non-Epithelial Ovarian Cancer, an Experience From Qatar
Non-Epithelial Ovarian Cancer, an Experience From Qatar Open
Background: Nonepithelial Ovarian cancers constitute about 10 % of all ovarian cancers. They are divided into Sex-cord stromal tumours (SCST) and Germ cell tumours (GCT). The Aim is to report the experience at National Centre for Cancer Ca…
View article: Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review
Primary mediastinal choriocarcinoma presenting as cutaneous metastasis with resistance to chemotherapy: case report and literature review Open
Cutaneous metastases of choriocarcinoma are rare. They may indicate poor prognosis and resistance to chemotherapy. In this report, we present a case of a 25‐year‐old man who presented with central pleuritic chest pain and right upper arm m…
View article: Pancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H)
Pancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H) Open
Aladdin Kanbour,1 Kakil Ibrahim Rasul,1 Salha Bujassoum Albader,1 Reem Jawad Al Sulaiman,1 Gayan Melikyan,2 Hanan Farghaly,3 Zsolt Lengyel,4 Yousef Al Rimawi,5 Dina Soliman,6 Nabil Elhadi Omar7 1Department of Medical Oncology, Hamad Medica…
View article: <p>Pancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H)</p>
Pancytopenia And Limbic Encephalopathy Complicating Immunotherapy For Clear Cell Endometrial Cancer With Microsatellite Instability-High (MSI-H) Open
We are presenting a case of a CCE with deficient mismatch repair that developed two autoimmune side effects, pancytopenia and limbic encephalitis, within a few days of a single injection of pembrolizumab.