Alagarraju Muthukumar
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View article: 67 Identification of a key bottleneck in the current CAP on-site peer inspections and its downstream effects
67 Identification of a key bottleneck in the current CAP on-site peer inspections and its downstream effects Open
The College of American Pathologists (CAP) oversees on-site peer inspections of more than 8,000 accredited laboratories on a biennial basis - a manual process involving multiple steps for the inspection teams as well as the inspected labor…
View article: Revisiting High-Sensitivity Cardiac Troponin Abnormal Baseline Cutoffs: Implications for AMI Diagnosis in the Emergency Department
Revisiting High-Sensitivity Cardiac Troponin Abnormal Baseline Cutoffs: Implications for AMI Diagnosis in the Emergency Department Open
Background: Current clinical guidelines recommend 52 ng/L as the abnormal baseline cutoff in high-sensitivity cardiac troponin (hs-cTn) algorithms for the rapid diagnosis of acute myocardial infarction (AMI). Though abnormal, this threshol…
View article: A-397 Creatinine Chaos: When Numbers Fail, Imaging Freezes
A-397 Creatinine Chaos: When Numbers Fail, Imaging Freezes Open
Background: As chronic disease rates rise, intravenous (IV) contrast usage for diagnostic imaging is increasing steadily. While IV procedures are largely safe, patients at risk of contrast-induced neuropathy (CIN) due to predisposing facto…
View article: B-192 Comparative evaluation of three extraction procedures for whole blood phosphatidyl ethanol analysis by liquid chromatography tandem mass spectrometry
B-192 Comparative evaluation of three extraction procedures for whole blood phosphatidyl ethanol analysis by liquid chromatography tandem mass spectrometry Open
Background Phosphatidylethanol (PEth) analysis is crucial for liver organ donor screening due to its high sensitivity and specificity as a biomarker for recent alcohol consumption, with a 2 to 4-weeks’ detection window. The predominant hom…
View article: A-106 Albumin-corrected Calcium: Should we use it or not?
A-106 Albumin-corrected Calcium: Should we use it or not? Open
Background Accurate assessment of calcium (Ca) level is important for proper classification of Ca status. Biologically active ionized Ca (iCa) is the best marker for precisely estimating functional Ca levels. However, the cost and pre-anal…
View article: A-218 Streamlining CAP on-site peer inspections: A digital solution to address key constraints of utilizing paper inspection packets
A-218 Streamlining CAP on-site peer inspections: A digital solution to address key constraints of utilizing paper inspection packets Open
Background The College of American Pathologists (CAP) peer inspection program relies heavily on printed inspection packets, which poses logistical, financial, and environmental challenges especially prior to summation. Although thousands o…
View article: SARS-CoV-2 vaccine failure rates and predictors of immune response in a diverse immunocompromised patient population
SARS-CoV-2 vaccine failure rates and predictors of immune response in a diverse immunocompromised patient population Open
Supported by a grant from Regeneron Pharmaceuticals, Inc., and P54 CA260560.
View article: Fatigued with Friedewald: why isn't everyone onboard yet with the new LDL-C equations?
Fatigued with Friedewald: why isn't everyone onboard yet with the new LDL-C equations? Open
View article: Performance Evaluation of Open Channel Buhlmann Fecal Calprotectin Turbo Assay on Abbott Alinity C Analyzer
Performance Evaluation of Open Channel Buhlmann Fecal Calprotectin Turbo Assay on Abbott Alinity C Analyzer Open
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal (GI) tract. Fecal calprotectin (fCAL) is a noninvasive laboratory test used in the diagnosis and monitoring of IBDs such as Crohn’s disease a…
View article: Crossroads between Autoimmunity and COVID-19 in Lung Transplant Recipients
Crossroads between Autoimmunity and COVID-19 in Lung Transplant Recipients Open
The presence of a certain group of auto-antibodies (AAbs) is known to correlate with the severity of COVID-19. It is, however, unknown if such AAbs are prevalent and impact COVID-19-related outcomes in lung transplant recipients (LTRs) who…
View article: B-063 Towards Improving mRNA Vaccine Effectiveness in Immunosuppressed Adults: Elucidating the Mechanisms and Evaluating Potential Improvement Strategies
B-063 Towards Improving mRNA Vaccine Effectiveness in Immunosuppressed Adults: Elucidating the Mechanisms and Evaluating Potential Improvement Strategies Open
Background The success of COVID-19 mRNA vaccines (Co-mV) has provided a renewed impetus in developing “onetime universal flu, COVID”, and other mRNA-based vaccines to offer broader and long-lasting protection. However, to bring this endeav…
View article: SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation
SARS-CoV-2 Vaccination IgG Antibody Responses in Patients with Hematologic Malignancies in a Myeloid Enriched Cohort: A Single Center Observation Open
Objective. Patients diagnosed with hematologic malignancies are at increased risk for severe SARS-CoV-2 infection. We evaluated the serological IgG response following two doses of the SARS-CoV-2 vaccine in patients with hematologic maligna…
View article: Do Monoclonal Antibody Therapies Improve 'Real-World' Outcomes of COVID-19 in Patients with Lymphoid Malignancies? the UT Southwestern Experience
Do Monoclonal Antibody Therapies Improve 'Real-World' Outcomes of COVID-19 in Patients with Lymphoid Malignancies? the UT Southwestern Experience Open
View article: Translation suppression underlies the restrained COVID-19 mRNA vaccine response in the high-risk immunocompromised group
Translation suppression underlies the restrained COVID-19 mRNA vaccine response in the high-risk immunocompromised group Open
Background Immunocompromised (IC) patients show diminished immune response to COVID-19 mRNA vaccines (Co-mV). To date, there is no ‘empirical’ evidence to link the perturbation of translation, a rate-limiting step for mRNA vaccine efficien…
View article: SARS-CoV-2 coinfections with variant genomic lineages identified by multiplex fragment analysis
SARS-CoV-2 coinfections with variant genomic lineages identified by multiplex fragment analysis Open
Immunocompromised patients can experience prolonged SARS-CoV-2 infections in the setting of a lack of protectivity immunity despite vaccination. As circulating SARS-CoV-2 strains become more heterogeneous, concomitant infection with multip…
View article: Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern
Multiplex Fragment Analysis for Flexible Detection of All SARS-CoV-2 Variants of Concern Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to emerge, and effective tracking requires rapid return of results. Surveillance of variants is typically performed by whole genome sequencing (WGS),…
View article: Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels
Comparison of Methods to Estimate Low-Density Lipoprotein Cholesterol in Patients With High Triglyceride Levels Open
In this cross-sectional study, the extended Martin/Hopkins equation offered greater LDL-C accuracy compared with the Friedewald and Sampson equations in patients with triglyceride levels of 400 to 799 mg/dL. However, regardless of method u…
View article: 178: Long-term impact of ivacaftor on health outcomes and mortality in people with cystic fibrosis in the U.S. CF Foundation Patient Registry (CFFPR)
178: Long-term impact of ivacaftor on health outcomes and mortality in people with cystic fibrosis in the U.S. CF Foundation Patient Registry (CFFPR) Open
View article: Silent SARS-CoV-2 Infections, Waning Immunity, Serology Testing, and COVID-19 Vaccination: A Perspective
Silent SARS-CoV-2 Infections, Waning Immunity, Serology Testing, and COVID-19 Vaccination: A Perspective Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causes a spectrum of clinical manifestations, ranging from asymptomatic to mild, moderate, or severe illness with multi-organ failure and death. Using a new machine learnin…
View article: Poor Humoral Response in Solid Organ Transplant Recipients Following Complete mRNA SARS-CoV-2 Vaccination
Poor Humoral Response in Solid Organ Transplant Recipients Following Complete mRNA SARS-CoV-2 Vaccination Open
View article: Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines
Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines Open
Background: Lung-transplant (LT) recipients are at high risk for COVID-19 due to immunosuppression and respiratory tropism of SARS-CoV-2. The information on the effect of COVID-19 mRNA vaccines to elicit immunogenic responses after a two-d…
View article: In-Depth Evaluation of a Case of Presumed Myocarditis After the Second Dose of COVID-19 mRNA Vaccine
In-Depth Evaluation of a Case of Presumed Myocarditis After the Second Dose of COVID-19 mRNA Vaccine Open
Supplemental Digital Content is available in the text.
View article: Myocarditis Temporally Associated With COVID-19 Vaccination
Myocarditis Temporally Associated With COVID-19 Vaccination Open
Supplemental Digital Content is available in the text.
View article: Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines
Serological Response in Lung Transplant Recipients after Two Doses of SARS-CoV-2 mRNA Vaccines Open
The immunological effectiveness of SARS-CoV-2 mRNA vaccines in lung transplant (LT) recipients is largely unknown. Thus, we assessed the effect of Pfizer-BioNTech and Moderna mRNA vaccines’ two-dose (2D) regimen on humoral responses in imm…
View article: Multiplex Fragment Analysis Identifies SARS-CoV-2 Variants
Multiplex Fragment Analysis Identifies SARS-CoV-2 Variants Open
The rapid spread of SARS-CoV-2 Variants of Concern (VOC) necessitates systematic efforts for epidemiological surveillance. The current method for identifying variants is viral whole genome sequencing (WGS). Broad clinical adoption of seque…
View article: Variable Creatinine Levels in Critical Care Patients: A Concerning Knowledge Gap
Variable Creatinine Levels in Critical Care Patients: A Concerning Knowledge Gap Open
An accurate creatinine (Cr) estimate is pivotal for the assessment of renal function. Both patient- and practice-spawned factors palliate the test accuracy of serum creatinine (sCr) and can erratically represent actual kidney function. Thi…
View article: Expanding COVID-19 Vaccine Availability: Role for Combined Orthogonal Serology Testing (COST)
Expanding COVID-19 Vaccine Availability: Role for Combined Orthogonal Serology Testing (COST) Open
Background: The persisting Coronavirus disease 2019 (COVID-19) pandemic and limited vaccine supply has led to a shift in global health priorities to expand vaccine coverage. Relying on severe acute respiratory syndrome coronavirus 2 (SARS-…
View article: Clinical Evaluation of the Abbott Alinity SARS-CoV-2 Spike-Specific Quantitative IgG and IgM Assays among Infected, Recovered, and Vaccinated Groups
Clinical Evaluation of the Abbott Alinity SARS-CoV-2 Spike-Specific Quantitative IgG and IgM Assays among Infected, Recovered, and Vaccinated Groups Open
The coronavirus disease 19 (COVID-19) pandemic continues to impose a significant burden on global health infrastructure. While identification and containment of new cases remains important, laboratories must now pivot and consider an asses…
View article: ‘nAb’ the self-reactive activity in the COVID-19 combat
‘nAb’ the self-reactive activity in the COVID-19 combat Open
View article: Clinical evaluation of the Abbott Alinity SARS-CoV-2 spike-specific quantitative IgG and IgM assays in infected, recovered, and vaccinated groups
Clinical evaluation of the Abbott Alinity SARS-CoV-2 spike-specific quantitative IgG and IgM assays in infected, recovered, and vaccinated groups Open
The COVID-19 pandemic continues to impose a significant burden on global health infrastructure. While identification and containment of new cases remains important, laboratories must now pivot and consider assessment of SARS-CoV-2 immunity…