Alain Brisson
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View article: Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease
Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease Open
The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the spleni…
View article: Prediction of COVID-19 disease progression by multiparametric analysis of circulating extracellular vesicles with flow cytometry
Prediction of COVID-19 disease progression by multiparametric analysis of circulating extracellular vesicles with flow cytometry Open
Extracellular vesicles (EVs) are released from all cells of the body. They are considered to mirror the state of the cells from which they are released and circulate in the blood, suggesting a possible use of EV analysis for diagnostic pur…
View article: Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells
Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells Open
Platelets are hyperactivated in coronavirus disease 2019 (COVID-19). However, the mechanisms promoting platelet activation by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood. This may be due to inherent…
View article: The diffusion of normal skin wound myofibroblast‐derived microvesicles differs according to matrix composition
The diffusion of normal skin wound myofibroblast‐derived microvesicles differs according to matrix composition Open
Microvesicles (MVs) are a subtype of extracellular vesicles that can transfer biological information over long distances, affecting normal and pathological processes including skin wound healing. However, the diffusion of MVs into tissues …
View article: Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment
Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment Open
Uveal melanoma (UM) is the most common primary intraocular tumor and often spreads to the liver. Intercellular communication though extracellular vesicles (EVs) plays an important role in several oncogenic processes, including metastasis, …
View article: Controlling Superselectivity of Multivalent Interactions with Cofactors and Competitors
Controlling Superselectivity of Multivalent Interactions with Cofactors and Competitors Open
Moieties that compete with multivalent interactions or act as cofactors are common in living systems, but their effect on multivalent binding remains poorly understood. We derive a theoretical model that shows how the superselectivity of m…
View article: Controlling superselectivity of multivalent interactions with cofactors and competitors
Controlling superselectivity of multivalent interactions with cofactors and competitors Open
Moieties that compete with multivalent interactions or act as cofactors are common in living systems, but their effect on multivalent binding remains poorly understood. We derive a theoretical model that shows how the superselectivity of m…
View article: Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells
Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells Open
Platelets are hyperactivated in coronavirus disease 2019 (COVID-19). However, the mechanisms promoting platelet activation by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood. This may be due to inherent…
View article: Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance
Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance Open
Clostridioides difficile is an environmentally acquired, anaerobic, spore-forming bacterium which ordinarily causes disease following antibiotic-mediated dysbiosis of the intestinal microbiota. Although much is understood regarding the lif…
View article: Quantitation of SARS-CoV-2 neutralizing antibodies with a virus-free, authentic test
Quantitation of SARS-CoV-2 neutralizing antibodies with a virus-free, authentic test Open
Neutralizing antibodies (NAbs), and their concentration in sera of convalescents and vaccinees are a correlate of protection from COVID-19. The antibody concentrations in clinical samples that neutralize SARS-CoV-2 are difficult and very c…
View article: Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles
Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles Open
Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from cells of the cardiovascular system, and are considered important mediators of intercellular and extracellular communications. Two types of EVs …
View article: Quantitation of SARS-CoV-2 neutralizing antibodies with a virus-free, authentic test
Quantitation of SARS-CoV-2 neutralizing antibodies with a virus-free, authentic test Open
Neutralizing antibodies (NAbs), and their concentration in sera of convalescents and vaccinees are a solid correlate of protection from COVID-19. The antibody concentrations in clinical samples that neutralize SARS-CoV-2 are difficult and …
View article: 404 Platelets are a source of extracellular mitochondria and mitochondrial DNA in systemic lupus erythematosus
404 Platelets are a source of extracellular mitochondria and mitochondrial DNA in systemic lupus erythematosus Open
Background The accumulation of DNA and nuclear components in blood and their recognition by autoantibodies play a central role in the pathophysiology of systemic lupus erythematosus (SLE). Despite the efforts, the sources of these circulat…
View article: Micellar Antibiotics of Bacillus
Micellar Antibiotics of Bacillus Open
Members of the Bacillus genus, particularly the “Bacillus subtilis group”, are known to produce amphipathic lipopeptides with biosurfactant activity. This includes the surfactins, fengycins and iturins that have been associated with antiba…
View article: Neural stem cells traffic functional mitochondria via extracellular vesicles
Neural stem cells traffic functional mitochondria via extracellular vesicles Open
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous cells was originally proposed as the primary healing mechanism of NSC grafts, it…
View article: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Open
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranou…
View article: Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts
Extracellular vesicles fail to trigger the generation of new cardiomyocytes in chronically infarcted hearts Open
Background: Extracellular vesicles (EV) mediate the therapeutic effects of stem cells but it is unclear whether this involves cardiac regeneration mediated by endogenous cardiomyocyte proliferation. Methods: Bi-transgenic MerCreMer/ZEG (n …
View article: Human milk triggers coagulation via tissue factor–exposing extracellular vesicles
Human milk triggers coagulation via tissue factor–exposing extracellular vesicles Open
Almost a century ago, it was discovered that human milk activates the coagulation system, but the milk component that triggers coagulation had until now been unidentified. In the present study, we identify this component and demonstrate th…
View article: Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis
Platelets Disseminate Extracellular Vesicles in Lymph in Rheumatoid Arthritis Open
Objective: The lymphatic system is a circulatory system that unidirectionally drains the interstitial tissue fluid back to blood circulation. Although lymph is utilized by leukocytes for immune surveillance, it remains inaccessible to plat…
View article: Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts
Extracellular vesicles from human cardiovascular progenitors trigger a reparative immune response in infarcted hearts Open
Aims The cardioprotective effects of human induced pluripotent stem cell-derived cardiovascular progenitor cells (CPC) are largely mediated by the paracrine release of extracellular vesicles (EV). We aimed to assess the immunological behav…
View article: MIFlowCyt‐EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments
MIFlowCyt‐EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments Open
Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual particles, but its application to the analysis of EVs and other submicron particles h…
View article: Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells
Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells Open
Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous cells was originally proposed as the primary healing mechanism of NSC grafts, it…
View article: CD63-GPC1-Positive Exosomes Coupled with CA19-9 Offer Good Diagnostic Potential for Resectable Pancreatic Ductal Adenocarcinoma
CD63-GPC1-Positive Exosomes Coupled with CA19-9 Offer Good Diagnostic Potential for Resectable Pancreatic Ductal Adenocarcinoma Open
Tumor-released extracellular vesicles (EVs) contain tumor-specific cargo distinguishing them from healthy EVs, and making them eligible as circulating biomarkers. Glypican 1 (GPC1)-positive exosome relevance as liquid biopsy elements is st…
View article: Comment on “Quality of extracellular vesicle images by transmission electron microscopy is operator and protocol dependent”
Comment on “Quality of extracellular vesicle images by transmission electron microscopy is operator and protocol dependent” Open
International audience
View article: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Open
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell‐released, membranou…
View article: Molecular subtypes and differentiation programmes of glioma stem cells as determinants of extracellular vesicle profiles and endothelial cell‐stimulating activities
Molecular subtypes and differentiation programmes of glioma stem cells as determinants of extracellular vesicle profiles and endothelial cell‐stimulating activities Open
We have previously uncovered the impact of oncogenic and differentiation processes on extracellular vesicles (EVs) in cancer. This is of interested in the context of glioma stem cells (GSC) that are responsible for recurrent nature of glio…