Alain Serraf
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View article: Renal memory in the Glenn-Fontan acute kidney injury continuum: A window for early renal protection
Renal memory in the Glenn-Fontan acute kidney injury continuum: A window for early renal protection Open
Background Acute kidney injury (AKI) is a common and serious complication following Fontan completion in children with single ventricle physiology. While risk factors for post-Fontan AKI are well studied, it remains unknown whether prior A…
View article: Virtual Post Mortem in fetuses and newborns for the Verification of Congenital Heart Malformations
Virtual Post Mortem in fetuses and newborns for the Verification of Congenital Heart Malformations Open
Background and Objectives: Post-mortem examinations of fetuses and newborns with congenital anomalies pose significant challenges, especially in cases of induced termination of pregnancy. To address this, we explored the use of virtual pos…
View article: Hypothermia vs Normothermia in neonatal Arterial Switch Operation – Clinical outcomes and Myocardial preservation
Hypothermia vs Normothermia in neonatal Arterial Switch Operation – Clinical outcomes and Myocardial preservation Open
Objectives: This study aims to compare the immediate postoperative clinical and laboratory outcomes, specifically focusing on the extent of cardiomyocyte death, between hypothermic (28°C) and normothermic (34–36°C) cardiopulmonary bypass i…
View article: The Fate of Mitral Valve Surgery in the Pediatric Age: A 25-Year Single-Center Experience
The Fate of Mitral Valve Surgery in the Pediatric Age: A 25-Year Single-Center Experience Open
Background: The aim of this study was to evaluate the natural history of patients after mitral valve intervention in the pediatric age. Methods: This is a retrospective study including all patients who underwent mitral valve surgery from 1…
View article: The Impact of Dominant Ventricular Morphology on the Early Postoperative Course after the Glenn Procedure
The Impact of Dominant Ventricular Morphology on the Early Postoperative Course after the Glenn Procedure Open
The dominant ventricular morphology affects both the early and late outcomes of the Fontan procedure, but its impact on the patients’ status immediately following the Glenn procedure is unknown. This study aimed to evaluate the effect of t…
View article: Dominant Ventricular Morphology and Early Postoperative Course After the Fontan Procedure
Dominant Ventricular Morphology and Early Postoperative Course After the Fontan Procedure Open
Background Single ventricle heart disease comprises a wide variety of critical heart defects that lead to the provision of systemic cardiac output by one dominant ventricle. It requires staged surgical palliation that culminates in Fontan …
View article: Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases
Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases Open
Autoimmune diseases affect 5% to 8% of the population, and females are more susceptible to these diseases than males. Here, we analyzed human thymic transcriptome and revealed sex-associated differences in the expression of tissue-specific…