Alain Simplice Leutou
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View article: Synergistic action between peptide-neomycin conjugates and polymyxin B against multidrug-resistant gram-negative pathogens
Synergistic action between peptide-neomycin conjugates and polymyxin B against multidrug-resistant gram-negative pathogens Open
Globally, it is predicted that by 2050, 10 million people will die annually because of infections with drug-resistant bacteria. Since antibacterial agents with novel mechanisms of action have not been developed in the past 30 years, there …
View article: Nucleic Acid Specificity, Cellular Localization and Reduced Toxicities of Thiazole Orange‐Neomycin Conjugates
Nucleic Acid Specificity, Cellular Localization and Reduced Toxicities of Thiazole Orange‐Neomycin Conjugates Open
Selective binding of small molecule ligands to nucleic acids with high affinity and limited toxicity remains an important goal in the development of compounds that can probe DNA or RNA in cells. Thiazole orange is a cell semi‐permeant, flu…
View article: Anti-Inflammatory Activity of Glycolipids and a Polyunsaturated Fatty Acid Methyl Ester Isolated from the Marine Dinoflagellate Karenia mikimotoi
Anti-Inflammatory Activity of Glycolipids and a Polyunsaturated Fatty Acid Methyl Ester Isolated from the Marine Dinoflagellate Karenia mikimotoi Open
A new monogalactosyldiacylglycerol (MGDG), a known monogalactosylmonoacylglycerol (MGMG) and a known polyunsaturated fatty acid methyl ester (PUFAME) were isolated from the marine dinoflagellate Karenia mikimotoi. The planar structure of t…
View article: Glycolipids and a Polyunsaturated Fatty Acid Methyl Ester Isolated from the Marine Dinoflagellate Karenia mikimotoi
Glycolipids and a Polyunsaturated Fatty Acid Methyl Ester Isolated from the Marine Dinoflagellate Karenia mikimotoi Open
A New monogalactosyldiacylglycerol (MGDG), a known monogalactosylmonoacylglycerol (MGMG) and a known polyunsaturated fatty acid methyl ester (PUFAME) were isolated from the marine dinoflagellate Karenia mikimotoi. The planar structure of t…
View article: Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment Open
Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemist…
View article: A New Secondary Metabolite from Korean Traditional Herb Plant <i>Hovenia dulcis</i>
A New Secondary Metabolite from Korean Traditional Herb Plant <i>Hovenia dulcis</i> Open
Investigation of chemical compounds from the butanol soluble layer of the traditional herb Hovenia dulcis has led to the isolation of a new compound, identified as 2-methoxybenzoic acid-5- O-α-L-rhamnopyranoside (1), along with three known…
View article: Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.
Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp. Open
Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the mur…
View article: Diacetoxyscirpenol as a new anticancer agent to target hypoxia-inducible factor 1
Diacetoxyscirpenol as a new anticancer agent to target hypoxia-inducible factor 1 Open
Hypoxia activates hypoxia-inducible factor 1, which promotes the progression of malignancy by stimulating angiogenesis and by augmenting the ability of tumors to survive. Thus, HIF-1 is one of the most compelling targets for treating cance…
View article: Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts
Extreme effects of Seabuckthorn extracts on influenza viruses and human cancer cells and correlation between flavonol glycosides and biological activities of extracts Open
View article: New Production of Antibacterial Polycyclic Quinazoline Alkaloid, Thielaviazoline, from Anthranilic Acid by the Marine-Mudflat-Derived Fungus<i>Thielavia</i>sp.
New Production of Antibacterial Polycyclic Quinazoline Alkaloid, Thielaviazoline, from Anthranilic Acid by the Marine-Mudflat-Derived Fungus<i>Thielavia</i>sp. Open
The microbial transformation of anthranilic acid (1) by the marine-mudflat-derived fungus Thielavia sp. produced an antibacterial polycyclic quinazoline alkaloid, thielaviazoline (2). The stereostructure of the metabolite was assigned base…
View article: Cristazine, a New Cytotoxic Dioxopiperazine Alkaloid from the Mudflat-Sediment-Derived Fungus <i>Chaetomium cristatum</i>
Cristazine, a New Cytotoxic Dioxopiperazine Alkaloid from the Mudflat-Sediment-Derived Fungus <i>Chaetomium cristatum</i> Open
Cristazine (1), a new class of dioxopiperazine alkaloid, along with previously isolated chetomin (2), neoechinulin A (3), and golmaenone (4), were isolated from the mudflat-sediment-derived fungus Chaetomium cristatum. The structure and ab…
View article: Violapyrone J, α-Pyrone Derivative from a Marine-derived Actinomycetes,<i>Streptomyces</i>sp.
Violapyrone J, α-Pyrone Derivative from a Marine-derived Actinomycetes,<i>Streptomyces</i>sp. Open
A new α-pyrone derivative, violapyrone J (1), and along with the two known violapyrones B (2) and C (3) were isolated from the fermentation broth of a marine actinomycete Streptomyces sp. SC0718. The structure of violapyrone J (1) was eluc…
View article: The Inhibitory Effect of Alisol A 24-Acetate from<i>Alisma canaliculatum</i>on Osteoclastogenesis
The Inhibitory Effect of Alisol A 24-Acetate from<i>Alisma canaliculatum</i>on Osteoclastogenesis Open
Osteoporosis is a disease that decreases bone mass. The number of patients with osteoporosis has been increasing, including an increase in patients with bone fractures, which lead to higher medical costs. Osteoporosis treatment is all-impo…