Alaji Bah
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View article: Uncovering the Molecular Interactions Underlying MBD2 and MBD3 Phase Separation
Uncovering the Molecular Interactions Underlying MBD2 and MBD3 Phase Separation Open
Chromatin organization controls DNA's accessibility to regulatory factors to influence gene expression. Heterochromatin, or transcriptionally silent chromatin enriched in methylated DNA and methylated histone tails, self-assembles through …
View article: Uncovering the molecular interactions underlying MBD2 and MBD3 phase separation
Uncovering the molecular interactions underlying MBD2 and MBD3 phase separation Open
Chromatin organization controls DNA’s accessibility to regulatory factors to influence gene expression. Heterochromatin, or transcriptionally silent chromatin enriched in methylated DNA and methylated histone tails, self-assembles through …
View article: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of transcription-translation negative feedback loops that pace rhythms of gene expression to the diurnal cycle. In the filamentous fungus Neurospora crassa, the proteins F requency ( F RQ), the F RQ-interactin…
View article: Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Full text Figures and data Peer review Side by side Abstract eLife assessment eLife digest Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract Circadian clocks …
View article: Reviewer #2 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Reviewer #2 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…
View article: Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…
View article: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…
View article: Reviewer #1 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Reviewer #1 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…
View article: Complex interplay between FMRP and DHX9 during DNA replication stress
Complex interplay between FMRP and DHX9 during DNA replication stress Open
Mutations in, or deficiency of, fragile X messenger ribonucleoprotein (FMRP) is responsible for the Fragile X syndrome (FXS), the most common cause for inherited intellectual disability. FMRP is a nucleocytoplasmic protein, primarily chara…
View article: Reviewer #2 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Reviewer #2 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed from molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repre…
View article: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of transcription-translation negative feedback loops that pace rhythms of gene expression to the diurnal cycle. In the filamentous fungus Neurospora crassa, the proteins F requency ( F RQ), the F RQ-interactin…
View article: Reviewer #1 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Reviewer #1 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed from molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repre…
View article: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed from molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repre…
View article: Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Author Response: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
View article: Reviewer #3 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Reviewer #3 (Public Review): Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed from molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repre…
View article: BME Weights for Non-Phosphorylated and 5-Phosphorylated 4E-BP2 ensembles generated with FastFloppyTail Deposited on the PED
BME Weights for Non-Phosphorylated and 5-Phosphorylated 4E-BP2 ensembles generated with FastFloppyTail Deposited on the PED Open
Bayesian Maximum Entropy (BME) weights for NP- and 5P-4E-BP2 ensembles deposited on the Protein Ensemble Database (PED). 5p_100* correspond to weights for the N = 100 5-phosphorylated conformer ensemble, np_1000* correspond to weights for …
View article: BME Weights for Non-Phosphorylated and 5-Phosphorylated 4E-BP2 ensembles generated with FastFloppyTail Deposited on the PED
BME Weights for Non-Phosphorylated and 5-Phosphorylated 4E-BP2 ensembles generated with FastFloppyTail Deposited on the PED Open
Bayesian Maximum Entropy (BME) weights for NP- and 5P-4E-BP2 ensembles deposited on the Protein Ensemble Database (PED). 5p_100* correspond to weights for the N = 100 5-phosphorylated conformer ensemble, np_1000* correspond to weights for …
View article: Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modeling and Clustering
Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modeling and Clustering Open
The intrinsically disordered 4E-BP2 protein regulates mRNA cap-dependent translation through interaction with the predominantly folded eukaryotic initiation factor 4E (eIF4E). Phosphorylation of 4E-BP2 dramatically reduces the level of eIF…
View article: Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modelling and Clustering
Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modelling and Clustering Open
The intrinsically disordered 4E-BP2 protein regulates mRNA cap-dependent translation through the interaction with the predominantly folded eukaryotic initiation factor 4E (eIF4E). Phosphorylation of 4E-BP2 dramatically reduces eIF4E bindin…
View article: ABI1 regulates transcriptional activity of Androgen Receptor by novel DNA and AR binding mechanism
ABI1 regulates transcriptional activity of Androgen Receptor by novel DNA and AR binding mechanism Open
Transcription regulates key functions of living organisms in normal and disease states, including cell growth and development, embryonic and adult tissue organization, and tumor progression. Here we identify a novel mechanism of transcript…
View article: Abstract 2703: Elucidating the Mechanism of MBD Protein LLPS and its Role in Heterochromatin Formation and Transcriptional Repression
Abstract 2703: Elucidating the Mechanism of MBD Protein LLPS and its Role in Heterochromatin Formation and Transcriptional Repression Open
View article: Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock
Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock Open
Circadian clocks are composed of molecular oscillators that pace rhythms of gene expression to the diurnal cycle. Therein, transcriptional-translational negative feedback loops (TTFLs) generate oscillating levels of transcriptional repress…
View article: Coevolution of the Ess1-CTD axis in polar fungi suggests a role for phase separation in cold tolerance
Coevolution of the Ess1-CTD axis in polar fungi suggests a role for phase separation in cold tolerance Open
Most of the world’s biodiversity lives in cold (−2° to 4°C) and hypersaline environments. To understand how cells adapt to such conditions, we isolated two key components of the transcription machinery from fungal species that live in extr…
View article: Multisite phosphorylation and binding alter conformational dynamics of the 4E-BP2 protein
Multisite phosphorylation and binding alter conformational dynamics of the 4E-BP2 protein Open
View article: FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase
FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase Open
The author has withdrawn this manuscript due to a duplicate posting of manuscript number 440759. Therefore, the author does not wish this work to be cited as reference for the project. If you have any questions, please contact the correspo…
View article: Multisite Phosphorylation and Binding Alter Conformational Dynamics of the 4E-BP2 Protein
Multisite Phosphorylation and Binding Alter Conformational Dynamics of the 4E-BP2 Protein Open
Intrinsically disordered proteins (IDPs) play critical roles in regulatory protein interactions, but detailed structural/dynamics characterization of their ensembles remain challenging, both in isolation and they form dynamic ‘fuzzy’ compl…
View article: Interleukin‐2‐inducible T‐cell kinase (Itk) signaling regulates potent noncanonical regulatory T cells
Interleukin‐2‐inducible T‐cell kinase (Itk) signaling regulates potent noncanonical regulatory T cells Open
Regulatory T cells (Tregs) play an important role in controlling autoimmunity and limiting tissue damage and inflammation. IL2‐inducible T cell kinase (Itk) is part of the Tec family of tyrosine kinases and is a critical component of T cel…
View article: The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect Open
View article: Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition
Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition Open
View article: A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation
A Tale of Loops and Tails: The Role of Intrinsically Disordered Protein Regions in R-Loop Recognition and Phase Separation Open
R-loops are non-canonical, three-stranded nucleic acid structures composed of a DNA:RNA hybrid, a displaced single-stranded (ss)DNA, and a trailing ssRNA overhang. R-loops perform critical biological functions under both normal and disease…