Alan B. Moran
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View article: Mass spectrometric analysis of lipid-linked oligosaccharide heterogeneity in genetically modified E. coli used for glycoconjugate bacterial vaccine production
Mass spectrometric analysis of lipid-linked oligosaccharide heterogeneity in genetically modified E. coli used for glycoconjugate bacterial vaccine production Open
Polysaccharide-based glycoconjugate bacterial vaccines can help combat multidrug-resistant pathogens by harnessing the immune system to recognize and neutralize bacteria effectively. Bacterial cells can be engineered to link O-antigen poly…
View article: Enhanced α2-3–linked sialylation determines the extended half-life of CHO-rVWF
Enhanced α2-3–linked sialylation determines the extended half-life of CHO-rVWF Open
The half-life of recombinant human von Willebrand factor (rVWF) expressed in CHO cells (CHO-rVWF; Vonicog alfa; and Vonvendi/Veyvondi) is significantly longer than that of plasma-derived VWF (pdVWF). This finding is intriguing because CHO …
View article: Mass Spectrometric Analysis of Lipid-Linked Oligosaccharide Heterogeneity in Genetically Modified E. Coli Used for Glycoconjugate Bacterial Vaccine Production
Mass Spectrometric Analysis of Lipid-Linked Oligosaccharide Heterogeneity in Genetically Modified E. Coli Used for Glycoconjugate Bacterial Vaccine Production Open
View article: Comprehensive characterization of bacterial glycoconjugate vaccines by liquid chromatography - mass spectrometry
Comprehensive characterization of bacterial glycoconjugate vaccines by liquid chromatography - mass spectrometry Open
Bacterial pathogens can cause a broad range of infections with detrimental effects on health. Vaccine development is essential as multi-drug resistance in bacterial infections is a rising concern. Recombinantly produced proteins carrying O…
View article: Serum N-Glycosylation RPLC-FD-MS Assay to Assess Colorectal Cancer Surgical Interventions
Serum N-Glycosylation RPLC-FD-MS Assay to Assess Colorectal Cancer Surgical Interventions Open
A newly developed analytical strategy was applied to profile the total serum N-glycome of 64 colorectal cancer (CRC) patients before and after surgical intervention. In this cohort, it was previously found that serum N-glycome alterations …
View article: Software-Assisted Data Processing Workflow for Intact Glycoprotein Mass Spectrometry
Software-Assisted Data Processing Workflow for Intact Glycoprotein Mass Spectrometry Open
Intact protein analysis by mass spectrometry is important for several applications such as assessing post-translational modifications and biotransformation. In particular, intact protein analysis allows the detection of proteoforms that ar…
View article: Sialic Acid Derivatization of Fluorescently Labeled <i>N</i>-Glycans Allows Linkage Differentiation by Reversed-Phase Liquid Chromatography–Fluorescence Detection–Mass Spectrometry
Sialic Acid Derivatization of Fluorescently Labeled <i>N</i>-Glycans Allows Linkage Differentiation by Reversed-Phase Liquid Chromatography–Fluorescence Detection–Mass Spectrometry Open
Sialic acids have diverse biological roles, ranging from promoting up to preventing protein and cellular recognition in health and disease. The various functions of these monosaccharides are owed, in part, to linkage variants, and as a res…
View article: Egg yolk sialylglycopeptide: purification, isolation and characterization of <i>N</i>-glycans from minor glycopeptide species
Egg yolk sialylglycopeptide: purification, isolation and characterization of <i>N</i>-glycans from minor glycopeptide species Open
Naturally occurring asymmetric and triantennay N -glycans can be isolated from hen egg yolk glycopeptides.
View article: Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance
Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance Open
Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL infl…
View article: Profiling the proteoforms of urinary prostate-specific antigen by capillary electrophoresis – mass spectrometry
Profiling the proteoforms of urinary prostate-specific antigen by capillary electrophoresis – mass spectrometry Open
Early detection of prostate cancer may lead to the overdiagnosis and overtreatment of patients as well as missing significant cancers. The current diagnostic approach uses elevated serum concentrations of prostate-specific antigen (PSA) as…