Alan Buser
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View article: LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation
LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation Open
Significance Cancers and chronic infectious pathogens often evade immune-mediated elimination by suppressing T cell function via engaging inhibitory receptors expressed on T cells. The phospholipid lysophosphatidic acid (LPA) is often incr…
View article: RHOA-mediated mechanical force generation through Dectin-1
RHOA-mediated mechanical force generation through Dectin-1 Open
Dendritic cell-associated C-type lectin 1 (Dectin-1, also known as CLEC7A) is an innate immune pattern recognition receptor that recognizes β-glucan on the Candida albicans cell wall. Recognition of β-glucan by immune cells leads to phagoc…
View article: RHOA mediated mechanical force generation through Dectin-1
RHOA mediated mechanical force generation through Dectin-1 Open
Dectin-1 is an innate immune pattern recognition receptor which recognizes β-glucan on the Candida albicans ( C. albicans ) cell wall. Recognition of β-glucan by immune cells leads to phagocytosis, oxidative burst, cytokine and chemokine p…