Alan C. H. Ling
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View article: Harnessing Preference Optimisation in Protein LMs for Hit Maturation in Cell Therapy
Harnessing Preference Optimisation in Protein LMs for Hit Maturation in Cell Therapy Open
Cell and immunotherapy offer transformative potential for treating diseases like cancer and autoimmune disorders by modulating the immune system. The development of these therapies is resource-intensive, with the majority of drug candidate…
View article: Access Balancing in Storage Systems by Labeling Partial Steiner Systems
Access Balancing in Storage Systems by Labeling Partial Steiner Systems Open
Storage architectures ranging from minimum bandwidth regenerating encoded distributed storage systems to declustered-parity RAIDs can be designed using dense partial Steiner systems in order to support fast reads, writes, and recovery of f…
View article: Decompositions of Edge-Colored Digraphs: A New Technique in the Construction of Constant-Weight Codes and Related Families
Decompositions of Edge-Colored Digraphs: A New Technique in the Construction of Constant-Weight Codes and Related Families Open
We demonstrate that certain Johnson-type bounds are asymptotically exact for a variety of classes of codes, namely, constant-composition codes, nonbinary constant-weight codes, group divisible codes, and multiply constant-weight codes. We …
View article: Relative Difference Sets Partitioned by Cosets
Relative Difference Sets Partitioned by Cosets Open
We explore classical (relative) difference sets intersected with the cosets of a subgroup of small index. The intersection sizes are governed by quadratic Diophantine equations. Developing the intersections in the subgroup yields an intere…
View article: Resolvable Group Divisible Designs with Large Groups
Resolvable Group Divisible Designs with Large Groups Open
We prove that the necessary divisibility conditions are sufficient for the existence of resolvable group divisible designs with a fixed number of sufficiently large groups. Our method combines an application of the Rees product constructio…