Alan C. Seifert
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View article: Unsupervised semi-automated MRI segmentation detects cortical lesion expansion in chronic traumatic brain injury
Unsupervised semi-automated MRI segmentation detects cortical lesion expansion in chronic traumatic brain injury Open
Traumatic brain injury (TBI) is a risk factor for neurodegeneration and cognitive decline, yet the underlying pathophysiologic mechanisms are incompletely understood. This gap in knowledge is in part related to a lack of reliable and effic…
View article: Multi‐center benchmarking of cervical spinal cord <scp>RF</scp> coils for 7 T <scp>MRI</scp> : A traveling spines study
Multi‐center benchmarking of cervical spinal cord <span>RF</span> coils for 7 T <span>MRI</span> : A traveling spines study Open
Purpose The depth within the body, small diameter, long length, and varying tissue surrounding the spinal cord impose specific considerations when designing RF coils. The optimal coil configuration for 7 T cervical spinal cord MRI is unkno…
View article: Chronic Traumatic Encephalopathy Neuropathologic Change is Infrequent Following Isolated Moderate-Severe Traumatic Brain Injury
Chronic Traumatic Encephalopathy Neuropathologic Change is Infrequent Following Isolated Moderate-Severe Traumatic Brain Injury Open
Chronic traumatic encephalopathy-neuropathologic change (CTE-NC) has been primarily studied in contact sport athletes with repetitive head impacts (RHI). An association with isolated traumatic brain injury (TBI) is less clear. We systemati…
View article: Multi-center benchmarking of cervical spinal cord RF coils for 7 T MRI: A traveling spines study
Multi-center benchmarking of cervical spinal cord RF coils for 7 T MRI: A traveling spines study Open
Purpose The depth within the body, small diameter, long length, and varying tissue surrounding the spinal cord impose specific considerations when designing radiofrequency coils. The optimal coil configuration for 7 T cervical spinal cord …
View article: Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study Open
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body …
View article: Cortical Lesion Expansion in Chronic Traumatic Brain Injury
Cortical Lesion Expansion in Chronic Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a risk factor for neurodegeneration and cognitive decline, yet the underlying pathophysiologic mechanisms are incompletely understood. This gap in knowledge is in part related to a lack of reliable and effic…
View article: Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study Open
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body …
View article: Thermal stimulus task <scp>fMRI</scp> in the cervical spinal cord at 7 Tesla
Thermal stimulus task <span>fMRI</span> in the cervical spinal cord at 7 Tesla Open
Although functional magnetic resonance imaging (fMRI) is widely applied in the brain, fMRI of the spinal cord is more technically demanding. Proximity to the vertebral column and lungs results in strong spatial inhomogeneity and temporal f…
View article: Researching COVID to enhance recovery (RECOVER) tissue pathology study protocol: Rationale, objectives, and design
Researching COVID to enhance recovery (RECOVER) tissue pathology study protocol: Rationale, objectives, and design Open
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, tra…
View article: Combining adhesive and nonadhesive injectable hydrogels for intervertebral disc repair in an ovine discectomy model
Combining adhesive and nonadhesive injectable hydrogels for intervertebral disc repair in an ovine discectomy model Open
Background Intervertebral disc (IVD) disorders (e.g., herniation) directly contribute to back pain, which is a leading cause of global disability. Next‐generation treatments for IVD herniation need advanced preclinical testing to evaluate …
View article: The neuropathology of intimate partner violence
The neuropathology of intimate partner violence Open
View article: Researching COVID to enhance recovery (RECOVER) autopsy tissue pathology study protocol: Rationale, objectives, and design
Researching COVID to enhance recovery (RECOVER) autopsy tissue pathology study protocol: Rationale, objectives, and design Open
Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, tra…
View article: Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – an in vivo rat model
Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – an in vivo rat model Open
View article: Thermal Stimulus Task fMRI in the Cervical Spinal Cord at 7 Tesla
Thermal Stimulus Task fMRI in the Cervical Spinal Cord at 7 Tesla Open
Purpose Although functional MRI is widely applied in the brain, fMRI of the spinal cord is more technically demanding. Proximity to the vertebral column and lungs results in strong spatial inhomogeneity and temporal fluctuations in B 0 . I…
View article: Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – An In Vivo Rat Model
Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – An In Vivo Rat Model Open
BACKGROUND CONTEXT : Endplate (EP) injury plays critical roles in painful IVD degeneration since Modic changes (MCs) are highly associated with pain. Models of EP microfracture that progress to painful conditions are needed to better under…
View article: Multimodal Assessment of Bottlenose Dolphin Auditory Nuclei Using 7-Tesla MRI, Immunohistochemistry and Stereology
Multimodal Assessment of Bottlenose Dolphin Auditory Nuclei Using 7-Tesla MRI, Immunohistochemistry and Stereology Open
The importance of assessing neurochemical processes in the cetacean brain as a tool for monitoring their cognitive health and to indirectly model human neurodegenerative conditions is increasingly evident, although available data are large…
View article: Impact of autocalibration method on accelerated EPI of the cervical spinal cord at 7 T
Impact of autocalibration method on accelerated EPI of the cervical spinal cord at 7 T Open
Purpose The spinal cord contains sensorimotor neural circuits of scientific and clinical interest. However, spinal cord functional MRI (fMRI) is significantly more technically demanding than brain fMRI, due primarily to its proximity to th…
View article: Ex situ perfusion fixation for brain banking: a technical report
Ex situ perfusion fixation for brain banking: a technical report Open
Perfusion fixation is a well-established technique in animal research to improve preservation quality in the study of many tissues, including the brain. There is a growing interest in using perfusion to fix postmortem human brain tissue to…
View article: Neuropathology of Pediatric SARS-CoV-2 Infection in the Forensic Setting: Novel Application of Ex Vivo Imaging in Analysis of Brain Microvasculature
Neuropathology of Pediatric SARS-CoV-2 Infection in the Forensic Setting: Novel Application of Ex Vivo Imaging in Analysis of Brain Microvasculature Open
Two years into the COVID-19 pandemic, there are few published accounts of postmortem SARS-CoV-2 pathology in children. We report 8 such cases (4 infants aged 7–36 weeks, 4 children aged 5–15 years). Four underwent ex vivo magnetic resonanc…
View article: Selective augmentation of corticospinal motor drive with trans-spinal direct current stimulation in the cat
Selective augmentation of corticospinal motor drive with trans-spinal direct current stimulation in the cat Open
Anatomical current-flow modeling with physiological validation based on MEPs provides a framework to optimize muscle-specific tsDCS interventions. tsDCS targeting of representative motor pools enables muscle- and response-specific neuromod…
View article: Impact of Autocalibration Method on Accelerated Echo-Planar Imaging of the Cervical Spinal Cord at 7T
Impact of Autocalibration Method on Accelerated Echo-Planar Imaging of the Cervical Spinal Cord at 7T Open
Purpose The spinal cord contains sensorimotor neural circuits of scientific and clinical interest. However, spinal cord fMRI is significantly more technically demanding than brain fMRI due primarily to its proximity to the lungs. Accelerat…
View article: Improvement of magnetic resonance imaging using a wireless radiofrequency resonator array
Improvement of magnetic resonance imaging using a wireless radiofrequency resonator array Open
View article: Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers
Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers Open
View article: Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia
Leveraging high-resolution 7-tesla MRI to derive quantitative metrics for the trigeminal nerve and subnuclei of limbic structures in trigeminal neuralgia Open
Background Trigeminal Neuralgia (TN) is a chronic neurological disease that is strongly associated with neurovascular compression (NVC) of the trigeminal nerve near its root entry zone. The trigeminal nerve at the site of NVC has been exte…
View article: Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers
Author Correction: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers Open
View article: Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers
Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers Open
View article: Generic acquisition protocol for quantitative MRI of the spinal cord
Generic acquisition protocol for quantitative MRI of the spinal cord Open
View article: Improvement of Brain MRI at 7T Using an Inductively Coupled RF Resonator\n Array
Improvement of Brain MRI at 7T Using an Inductively Coupled RF Resonator\n Array Open
It is well known that magnetic resonance imaging (MRI) at 7 Tesla (7T) and\nhigher magnets can provide much better signal sensitivity compared with lower\nfield strengths. However, variety of commercially available ultra-high-field\nMRI co…
View article: Improvement of Brain MRI at 7T Using an Inductively Coupled RF Resonator Array
Improvement of Brain MRI at 7T Using an Inductively Coupled RF Resonator Array Open
It is well known that magnetic resonance imaging (MRI) at 7 Tesla (7T) and higher magnets can provide much better signal sensitivity compared with lower field strengths. However, variety of commercially available ultra-high-field MRI coils…
View article: Formalin tissue fixation biases myelin‐sensitive MRI
Formalin tissue fixation biases myelin‐sensitive MRI Open
Purpose Chemical fixatives such as formalin form cross‐links between proteins and affect the relaxation times and diffusion properties of tissue. These fixation‐induced changes likely also affect myelin density measurements produced by qua…