Alan Connelly
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View article: O04 Reintroducing pen and leaving quin-alone: examining the impact of a penicillin allergy de-labelling project on antibiotic prescribing in a hospital setting
O04 Reintroducing pen and leaving quin-alone: examining the impact of a penicillin allergy de-labelling project on antibiotic prescribing in a hospital setting Open
Background The label of penicillin allergy is carried by between 8 and 25% of all patients (1). Alternative antibiotics may not be as efficacious, can be more expensive and lead to more adverse effects (2). Interrogation of a penicillin al…
View article: Parameter Sensitivity of Network-Based Statistical Inference
Parameter Sensitivity of Network-Based Statistical Inference Open
The network-based statistic (NBS) is a popular method for performing edge-wise statistical inference on brain networks, with a known limitation in the form of a need for the user to pre-define an arbitrary cluster-forming threshold. Recent…
View article: Quantitative streamlines tractography: methods and inter-subject normalisation
Quantitative streamlines tractography: methods and inter-subject normalisation Open
Recent developments in semi-global tractogram optimisation algorithms have opened the field of diffusion magnetic resonance imaging (MRI) to the possibility of performing quantitative assessment of structural fibre ‘connectivity’. The prop…
View article: Predicting Post-Stroke Somatosensory Function from Resting-State Functional Connectivity: A Feasibility Study
Predicting Post-Stroke Somatosensory Function from Resting-State Functional Connectivity: A Feasibility Study Open
Accumulating evidence shows that brain functional deficits may be impacted by damage to remote brain regions. Recent advances in neuroimaging suggest that stroke impairment can be better predicted based on disruption to brain networks rath…
View article: Bilateral Structural Network Abnormalities in Epilepsy Associated With Bottom-of-Sulcus Dysplasia
Bilateral Structural Network Abnormalities in Epilepsy Associated With Bottom-of-Sulcus Dysplasia Open
We demonstrate evidence of a bilaterally distributed, specific white matter network that is vulnerable to disruption in BOSD. The degree of tract abnormality is partly related to seizure activity, but additional contributors such as the ge…
View article: Structural Connectivity Remote From Lesions Correlates With Somatosensory Outcome Poststroke
Structural Connectivity Remote From Lesions Correlates With Somatosensory Outcome Poststroke Open
Background and Purpose: Changes in connectivity of white matter fibers remote to a stroke lesion, suggestive of structural connectional diaschisis, may impact on clinical impairment and recovery after stroke. However, until recently, we ha…
View article: Tetraplegic obstructive sleep apnoea patients dilate the airway similarly to able-bodied obstructive sleep apnoea patients
Tetraplegic obstructive sleep apnoea patients dilate the airway similarly to able-bodied obstructive sleep apnoea patients Open
Context/objective: Obstructive sleep apnoea (OSA) develops soon after cervical spinal cord injury (SCI) at rates higher than the general population, but the mechanisms are not understood. This study aimed to determine whether OSA in SCI is…
View article: Characterisation of white matter asymmetries in the healthy human brain using diffusion MRI fixel-based analysis
Characterisation of white matter asymmetries in the healthy human brain using diffusion MRI fixel-based analysis Open
The diffusion tensor model for diffusion MRI has been used extensively to study asymmetry in the human brain white matter. However, given the limitations of the tensor model, the nature of any underlying asymmetries remains uncertain, part…
View article: Notes on “A cautionary note on the use of SIFT in pathological connectomes”
Notes on “A cautionary note on the use of SIFT in pathological connectomes” Open
“… show that these two modifications [which we had mentioned in our Letter] do not alleviate the paradoxical conclusions that result when SIFT is used”, despite our prior demonstration that their erroneous inference of a 50% decrease in th…
View article: Quantitative streamlines tractography: methods and inter-subject normalisation
Quantitative streamlines tractography: methods and inter-subject normalisation Open
Recent developments in semi-global tractogram optimisation algorithms have opened the field of diffusion MRI to the possibility of performing quantitative assessment of structural fibre connectivity. The proper application of these methods…
View article: Mapping Structural Connectivity Using Diffusion <scp>MRI</scp>: Challenges and Opportunities
Mapping Structural Connectivity Using Diffusion <span>MRI</span>: Challenges and Opportunities Open
Diffusion MRI‐based tractography is the most commonly‐used technique when inferring the structural brain connectome, i.e., the comprehensive map of the connections in the brain. The utility of graph theory—a powerful mathematical approach …
View article: Severe childhood speech disorder
Severe childhood speech disorder Open
We identify the likely genetic etiology in 11 patients with CAS and implicate 9 genes for the first time. We find that CAS is often a sporadic monogenic disorder, and highly genetically heterogeneous. Highly penetrant variants implicate sh…
View article: Cognitive Behavioral Therapy for Antenatal Depression in a Pilot Randomized Controlled Trial and Effects on Neurobiological, Behavioral and Cognitive Outcomes in Offspring 3–7 Years Postpartum: A Perspective Article on Study Findings, Limitations and Future Aims
Cognitive Behavioral Therapy for Antenatal Depression in a Pilot Randomized Controlled Trial and Effects on Neurobiological, Behavioral and Cognitive Outcomes in Offspring 3–7 Years Postpartum: A Perspective Article on Study Findings, Limitations and Future Aims Open
Our explorative findings suggest that antenatal depression treatment decreases overall child DNA-methylation, increases cortical thickness, and decreases white matter fiber-bundle cross-section in regions involved in cognitive function and…
View article: Modulation of white matter bundle connectivity in the presence of axonal truncation pathologies
Modulation of white matter bundle connectivity in the presence of axonal truncation pathologies Open
Endpoint-to-endpoint fibre bundle connectivity estimated using spherical deconvolution & streamlines tractography in diffusion MRI may be excessive in the presence of pathologies that involve truncation of axons within the white matter. He…
View article: Maturation and interhemispheric asymmetry in neurite density and orientation dispersion in early childhood
Maturation and interhemispheric asymmetry in neurite density and orientation dispersion in early childhood Open
Background The brain’s white matter undergoes profound changes during early childhood, which are believed to underlie the rapid development of cognitive and behavioral skills during this period. Neurite density, and complexity of axonal pr…
View article: Mapping connectomes with diffusion MRI: Deterministic or probabilistic tractography?
Mapping connectomes with diffusion MRI: Deterministic or probabilistic tractography? Open
In the Discussion section of the manuscript entitled "Mapping connectomes with Diffusion MRI: deterministic or probabilistic tractography?",1 Sarwar and colleagues briefly mention a class of methods that aim to imbue a tractogram reconstru…
View article: Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores
Correlated Resting-State Functional MRI Activity of Frontostriatal, Thalamic, Temporal, and Cerebellar Brain Regions Differentiates Stroke Survivors with High Compared to Low Depressive Symptom Scores Open
Background. One in three survivors of stroke experience poststroke depression (PSD). PSD has been linked with poorer recovery of function and cognition, yet our understanding of potential mechanisms is currently limited. Alterations in res…
View article: Brain Magnetic Resonance Imaging Findings in Children after Antenatal Maternal Depression Treatment, a Longitudinal Study Built on a Pilot Randomized Controlled Trial
Brain Magnetic Resonance Imaging Findings in Children after Antenatal Maternal Depression Treatment, a Longitudinal Study Built on a Pilot Randomized Controlled Trial Open
Antenatal depression is associated with an increased risk of offspring neuro-developmental disorders, potentially as a consequence of an altered brain development in utero. We hypothesized that reducing maternal depression by Cognitive Beh…
View article: Early childhood development of white matter fiber density and morphology
Early childhood development of white matter fiber density and morphology Open
Early childhood is an important period for cognitive and brain development, though white matter changes specific to this period remain understudied. Here we utilize a novel analytic approach to quantify and track developmental changes in w…
View article: <i>In vivo</i>microstructural heterogeneity of white matter lesions in Alzheimer’s disease using tissue compositional analysis of diffusion MRI data
<i>In vivo</i>microstructural heterogeneity of white matter lesions in Alzheimer’s disease using tissue compositional analysis of diffusion MRI data Open
White matter hyperintensities (WMH) are commonly observed in elderly individuals, and are typically more prevalent in Alzheimer’s disease subjects than in healthy subjects. These lesions can be identified on fluid attenuated inversion reco…
View article: A Novel Method for Extracting Hierarchical Functional Subnetworks Based on a Multisubject Spectral Clustering Approach
A Novel Method for Extracting Hierarchical Functional Subnetworks Based on a Multisubject Spectral Clustering Approach Open
Brain network modularity analysis has attracted increasing interest due to its capability in measuring the level of integration and segregation across subnetworks. Most studies have focused on extracting modules at a single level, although…
View article: Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy
Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy Open
Objective Psychosis of epilepsy (POE) occurs more frequently in temporal lobe epilepsy, raising the question as to whether abnormalities of the hippocampus are aetiologically important. Despite decades of investigation, it is unclear wheth…